II. Types

  1. Pharmacokinetic (most common)
    1. Two drugs compete for the same mechanism of absorption, distribution, metabolism or excretion (ADME)
    2. Results in a change in one or both drugs concentration at the site of their action when both agents are taken
    3. Typically involves Cytochrome P450, UGT, P-Glycoprotein or OATP
    4. Often drug dosage changes and monitoring are sufficient for low to moderate risk interactions
  2. Pharmacodynamic
    1. One drug directly blocks or exacerbates another drugs activity without modifying drug concentrations
    2. Offending drug, typically must be stopped (drug dosage modifications typically do not resolve interaction)

III. Causes: Food Interactions

IV. Causes: Common Serious Drug-Drug Interactions

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Related Studies

Ontology: Food Interactions (C0242784)

Definition (CSP) physical chemical interaction between nutrients, or between nutrients and other components of the diet or other compounds, including desirable or undesirable results; nutrients are substances that can be metabolized by an organism to give energy and build tissue; for the concept of nutrients interacting with drugs use NUTRIENT DRUG INTERACTION.
Concepts Natural Phenomenon or Process (T070)
MSH D018565
English Food Interaction, Interaction, Food, Interactions, Food, nutrient interaction, Food interaction, food interactions, interactions nutrient, foods interactions, interaction food, food interaction, Food Interactions
Italian Interazione con il cibo, Interazioni alimentari
Japanese 食物との相互作用, ショクモツトノソウゴサヨウ
Portuguese Interações de Alimentos, Interacção com alimentos
Spanish Interacciones de Alimento, Interacción con alimentos
French Interactions alimentaires, Interactions des aliments, Interaction avec l'alimentation
German Nahrungsmittelinteraktionen, Wechselwirkung mit Nahrungsmitteln
Czech Potravinová interakce, interakce potravin, ovlivnění účinku léků potravou
Hungarian Étel kölcsönhatás
Dutch voedselinteractie

Ontology: Food-Drug Interactions (C0242785)

Definition (MSH) The pharmacological result, either desirable or undesirable, of drugs interacting with components of the diet. (From Stedman, 25th ed)
Definition (CSP) either desirable or undesirable pharmacological result of drugs interacting with nutrients; used for both drugs of abuse and pharmaceuticals interacting with nutrients.
Concepts Disease or Syndrome (T047)
MSH D018565
SnomedCT 95907004
English Drug Food Interactions, Drug-Food Interaction, Drug-Food Interactions, Food Drug Interactions, Food-Drug Interaction, Food-Drug Interactions, Interaction, Drug-Food, Interaction, Food-Drug, Interactions, Drug-Food, Interactions, Food-Drug, nutrient drug interaction, DRUG - FOOD INTERACTION, Drug - food interaction, drug interaction with food, drug-food interaction, drugs foods interactions, drugs interaction nutrient, drug-food interactions, drugs food interaction, drug interactions nutrient, drugs food interactions, interaction drug food, drug food interactions, drug interaction food, drug nutrient interaction, food-drug interaction, food-drug interactions, drugs interaction nutrients, drug food interaction, drug foods interaction, food drug interaction, interaction drug nutrient, drugs interactions nutrient, food drug interactions, Drug interaction with food (finding), Drug interaction with food (disorder), Drug-nutrient interactions, Drug interaction with food, Food interaction with drug
Dutch geneesmiddel-voedsel interactie, Interactie, voedsel-geneesmiddel-, Voedsel-geneesmiddelinteractie
French Interaction médicament-aliment, Interactions aliment-médicament, Interactions médicaments-aliments, Interactions aliments-médicaments, INTERACTION MEDICAMENT/ALIMENT, Interactions médicament-aliment
German Wechselwirkung von Medikamenten und Nahrungsmittel, Arzneimittel-Nahrungsmittel-Interaktionen, Nahrungsmittel-Arzneimittel-Interaktionen
Italian Interazione farmaco-cibo, Interazioni farmaci-alimenti
Portuguese Interacção fármaco-alimentos, INTERACAO MEDICAMENTO-ALIMENTO, Interações Alimento-Droga
Spanish Interacción de fármacos con alimentos, interacción de un fármaco con los alimentos, interacción de un fármaco con los alimentos (trastorno), interacción de fármaco con alimentos (hallazgo), interacción de los alimentos con una droga, interacción de fármaco con alimentos, Interacciones Alimento-Droga
Japanese 薬物・食物相互作用, ヤクブツショクモツソウゴサヨウ, 食品医薬品相互作用, 食品相互作用, 薬物食品相互作用, 食品薬物相互作用, 医薬品食品相互作用
Swedish Kost-läkemedelsinteraktioner
Czech interakce mezi potravou a léky, Interakce léku s potravinou, vzájemné působení léků s potravinami
Finnish Ruoka-lääkeaineinteraktiot
Polish Interakcja żywność-leki
Hungarian Gyógyszer - étel kölcsönhatás

Ontology: Drug Interactions (C0687133)

Definition (NCI_NCI-GLOSS) A change in the way a drug acts in the body when taken with certain other drugs, herbals, or foods, or when taken with certain medical conditions. Drug interactions may cause the drug to be more or less effective, or cause effects on the body that are not expected.
Definition (NCI) Alteration of the disposition and/or effect of a drug, owing to the presence of another factor such as a second drug, or food.
Definition (MSH) The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Definition (PSY) Chemical and/or pharmacological reactions of drugs in combination, including agonistic and antagonistic interactions.
Definition (CSP) physical chemical interaction between drugs and other compounds, including other drugs, particularly in biological systems.
Concepts Molecular Function (T044)
MSH D004347
SnomedCT 404204005, 79899007, 277359009
English Drug Interactions, Interaction, Drug, Interactions, Drug, Interaction, Drug Interaction, Drug interaction (NOS), Drug interaction NOS, Interaction drug (NOS), Interactions, drug drug interaction, drug-drug interaction, drug interaction with, drug interactions, drug interaction, Drug interaction with drug (finding), Drug interaction with drug (disorder), Drug interaction (finding), Drug interaction (disorder), drug interaction (treatment), Drug interactions, INTERACTION, Drug interaction, Drug drug interaction, Drug interaction with drug
Italian Interazione farmacologica, Interazioni, Interazione, Interazione farmacologica (NAS), Interazione farmacologica NAS, Interazioni farmacologiche
Dutch interactie geneesmiddel (NAO), interactie, geneesmiddeleninteractie NAO, geneesmiddelinteractie (NAO), geneesmiddelinteractie, interacties, Geneesmiddeleninteractie, Interactie, geneesmiddelen-
French Interaction médicamenteuse SAI, Interaction, Interaction médicamenteuse, Interactions, Interactions médicamenteuses
German Wechselwirkung, Arzneimittelwechselwirkung NNB, Wechselwirkung, Arzneimittel (NNB), Arzneimittelwechselwirkung (NNB), Arzneimittelwechselwirkung, Wechselwirkungen, Arzneimittelwechselwirkungen
Portuguese Interacção, Interacção farmacológica NE, Interacção de fármacos NE, Interacção medicamentosa, Interacções, Interações de Medicamentos
Spanish Interacción medicamentosa NEOM, Interacción medicamentosa (NEOM), Interacción, interacción farmacológica (trastorno), interacción farmacológica (hallazgo), interacción medicamentosa (hallazgo), interacción medicamentosa (trastorno), interacción fármaco-fármaco, interacción farmacológica, Interacciones, Interacción medicamentosa, interacción medicamentosa, Interacciones de Drogas
Japanese 薬物相互作用NOS, 薬物相互作用, 薬物相互作用(NOS), 相互作用, ソウゴサヨウ, ヤクブツソウゴサヨウNOS, ヤクブツソウゴサヨウ
Swedish Läkemedelsinteraktioner
Finnish Lääkkeiden interaktiot
Czech Léková interakce NOS, Interakce, Vzájemná působení, Léková interakce, Léková interakce (NOS), léky - interakce, lékové interakce
Polish Interakcja leków, Interakcja substancji chemicznych
Hungarian Gyógyszerkölcsönhatás (k.m.n.), Gyógyszerkölcsönhatás k.m.n., Kölcsönhatás, Gyógyszerkölcsönhatás, Kölcsönhatások, Gyógyszer kölcsönhatás (k.m.n.)