II. Background

  1. Fat-soluble, Vitamin-like quinone
  2. Endogenous compound used in Energy Metabolism
  3. Highest concentrations in heart, brain, liver, Kidney
  4. Activity
    1. Central to electron transfer in ATP production
    2. Antioxidant scavenger
    3. Decreases Calcium overload
    4. Protective against ischemia in CHF

III. Indications: Neurologic

IV. Indications: Cardiovascular (50-200 mg/day)

  1. Congestive Heart Failure (CHF) - unclear benefit
  2. Hypertension - insufficient evidence
  3. Coronary Artery Disease - experimental

V. Indications: Miscellaneous

  1. Diabetes Mellitus (100-200 mg/day) - unclear benefit

VI. Adverse effects

  1. Gastrointestinal upset
  2. Potential risk of Hypoglycemia, Hypotension

VII. Disadvantages

  1. Expensive: (1200 mg/day costs $300/month)

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