II. Background
- Fat-soluble, Vitamin-like quinone
- Endogenous compound used in Energy Metabolism within mitochondria
- Highest concentrations in heart, brain, liver, Kidney
- Activity
- Central to electron transfer in ATP production
- Antioxidant scavenger against free radicals
- Decreases Calcium overload
- Protective against ischemia in CHF
III. Medications
- Ubiquinone
- Ubiquinol
IV. Indications: Neurologic
- Parkinsonism (360-1200 mg orally daily)
- Migraine Headaches (150-300 mg orally daily)
V. Indications: Cardiovascular (50-200 mg/day)
- Congestive Heart Failure (CHF) - unclear benefit
- Hypertension - insufficient evidence
- Coronary Artery Disease - experimental
-
Statin-Induced Myopathy
- Conflicting evidence for benefit
VI. Indications: Miscellaneous
- Diabetes Mellitus (100-200 mg/day) - unclear benefit
- Symptomatic deficiency (rare)
- Effective
- MItochondrial Myopathy (rare, genetic or acquired)
- Effective
VII. Adverse effects
- Gastrointestinal upset (e.g. Diarrhea)
- Divide twice daily for doses >100 mg/day to reduce adverse effects
- Potential risk of Hypoglycemia, Hypotension
VIII. Safety
- Unknown safety in pregnancy
- Unknown safety in Lactation
IX. Drug Interactions
X. References
- (2024) Presc Lett 31(1): 6
- Bonakdar (2005) Am Fam Physician 72:1065-70 [PubMed]
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Related Studies
| Definition (NCI_NCI-GLOSS) | A nutrient that the body needs in small amounts to function and stay healthy. Coenzyme Q10 helps mitochondria (small structures in the cell) make energy. It is an antioxidant that helps prevent cell damage caused by free radicals (highly reactive chemicals). Coenzyme Q10 is fat-soluble (can dissolve in fats and oils) and is found in fatty fish, beef, soybeans, peanuts, and spinach. It is being studied in the prevention and treatment of some types of cancer and heart disease and in the relief of side effects caused by some cancer treatments. |
| Definition (NCI) | A naturally occurring benzoquinone important in electron transport in mitochondrial membranes. Coenzyme Q10 functions as an endogenous antioxidant; deficiencies of this enzyme have been observed in patients with many different types of cancer and limited studies have suggested that coenzyme Q10 may induce tumor regression in patients with breast cancer. This agent may have immunostimulatory effects. (NCI04) |
| Definition (PDQ) | A naturally occurring benzoquinone important in electron transport in mitochondrial membranes. Coenzyme-Q functions as an endogenous antioxidant; deficiencies of this enzyme have been observed in patients with many different types of cancer and limited studies have suggested that coenzyme-Q may induce tumor regression in patients with breast cancer. This agent may have immunostimulatory effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39187&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39187&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C916" NCI Thesaurus) |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) , Biologically Active Substance (T123) |
| MSH | C024989 |
| SnomedCT | 412129003, 412130008 |
| English | 2,3-dimethoxy-5-methyl-6-decaprenylbenzoquinone, CoQ 10, CoQ10, ubiquinone 50, ubiquinone Q10, coenzyme Q10, coenzyme-Q10, coenzyme Q10 (medication), Bio-Quinone Q10, coenzyme Q10 [Chemical/Ingredient], coenzymes q10, q10 ubiquinone, coenzyme q10, coq10, coq 10, q10 coenzyme, UBIDECARENONE, ubidecarenone, Co Q-10, vitamin Q10, Q10, Co-Q10, Coenzyme Co Q10, Coq10, Coenzyme Q10, Coenzyme Q10 (product), Coenzyme Q10 (substance), Ubidecarenone, COENZYME Q10 |
| Spanish | coenzima Q10 (producto), coenzima Q10 (sustancia), coenzima Q10, ubidecarenona |
Ontology: ubiquinol (C0077656)
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | C003741 |
| English | ubiquinol |
