II. Sources
III. Pharmacokinetics: Toxicity
- Oral Bioavailability: 80%
- Toxic Doses
- Toxicity within hours to days of large ingestion
- Hepatic metabolism
- Excreted in feces and urine
IV. Findings
- Gastrointestinal
- Neurologic
- Pseudotumor Cerebri (intracranial Hypertension)
- Headache
- Blurred Vision
- Papilledema
- Endocrine
- Hypercalcemia (chronic ingestion)
- Skin (late finding)
- Skin Desquamation
- Alopecia
V. Labs
- See Unknown Ingestion
- Comprehensive metabolic panel (including serum Electrolytes, Serum Calcium, Liver Function Tests)
-
Lumbar Puncture
- Indicated in suspected Pseudotumor Cerebri or Altered Level of Consciousness
VI. Management
- See Unknown Ingestion
- Evaluate all ingestions >300,000 IU
-
Activated Charcoal
- Indicated if ingestion in last 1-2 hours and patient able to control airway, Emesis
- Supportive care
- Hypercalcemia management as needed
- Observe symptomatic patients
- Intracranial Hypertension
VII. References
- Tomaszewski (2023) Crit Dec Emerg Med 37(12): 32
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Related Studies
| Definition (MSH) | A symptom complex resulting from ingesting excessive amounts of VITAMIN A. |
| Concepts | Disease or Syndrome (T047) |
| MSH | D006986 |
| ICD9 | 278.2 |
| ICD10 | E67.0 |
| SnomedCT | 64559002 |
| English | Hypervitaminosis A, hypervitaminosis A, hypervitaminosis A (diagnosis), A-hypervitaminosis, Hypervitaminosis a, Hypervitaminosis A [Disease/Finding], Hypervitaminosis A (disorder), A; hypervitaminosis, hyperalimentation; vitamin A, hypervitaminosis; A, vitamin A; hyperalimentation |
| Dutch | A-hypervitaminose, A; hypervitaminose, hyperalimentatie; vitamine A, hypervitaminose; A, vitamine A; hyperalimentatie, hypervitaminose A, Hypervitaminose A, Vitaminose A, hyper- |
| Japanese | ビタミンＡ過剰症, ﾋﾞﾀﾐﾝAｶｼﾞｮｳｼｮｳ |
| Swedish | Hypervitaminos A |
| Czech | hypervitaminóza A, Hypervitaminóza A |
| Finnish | A-hypervitaminoosi |
| Russian | GIPERVITAMINOZ A, ГИПЕРВИТАМИНОЗ A |
| Korean | 과비타민 A증 |
| Polish | Hiperwitaminoza A |
| Hungarian | A-hypervitaminosis, Hypervitaminosis A |
| Norwegian | Hypervitaminosis A, Hypervitaminose A, A- hypervitaminosis |
| Spanish | hipervitaminosis A (trastorno), hipervitaminosis A, Hipervitaminosis A |
| French | Hypervitaminose A |
| German | Hypervitaminose A |
| Italian | Ipervitaminosi A |
| Portuguese | Hipervitaminose A |
Ontology: Poisoning by vitamin A (C0242153)
| Concepts | Injury or Poisoning (T037) |
| SnomedCT | 47237001 |
| English | vitamin A toxicity, vitamin A toxicity (diagnosis), toxicity from vitamin A, toxicity vitamins, vitamin a toxicity, toxicities vitamin, Poisoning by vitamin A, Vitamin A intoxication, Vitamin A toxicity, Vitamin A poisoning, Poisoning by vitamin A (disorder) |
| Spanish | intoxicación por vitamina A (trastorno), intoxicación por vitamina A, toxicidad por vitamina A |
Ontology: Vitamin A overdose (C0573813)
| Concepts | Injury or Poisoning (T037) |
| SnomedCT | 296949004 |
| English | vitamin a overdose, overdose vitamin a, Vitamin A overdose, Vitamin A overdose (disorder) |
| Spanish | sobredosis de vitamina A (trastorno), sobredosis de vitamina A |
