II. Indications
III. Contraindications
-
Hemodialysis (caution)
- Risk of Aluminum accumulation
IV. Mechanism
- Sucralfate is a nonabsorbable, aluminum salt of sucrose orasulfate
- Polymerizes atlow pH (e.g. Stomach acid)
- Sucralfate is negatively charged and binds positively charged Proteins on mucosal surface
- Creates a protective coating that overlies the mucosa, and prevents mucositis and Peptic Ulcer formation
- May also stimulate mucus production by triggering local Prostaglandin E2 release
V. Dosing
- Adult
- Take 1 gram orally four times daily at one hour before meals and at bedtime
- May decrease to twice daily for maintenance therapy
- Child (off label)
- Age <6 years
- Give 40 to 80 mg/kg/day divided four times daily up to 500 mg orally every 6 hours
- Age >6 years
- Give 1 gram orally four times daily at one hour before meals and at bedtime
- Age <6 years
VI. Adverse Effects
VII. Safety
- Pregnancy Category B
- Unknown safety in Lactation
VIII. Pharmacokinetcs
- Absorption of only 3 to 5%
IX. Drug Interactions
-
Antacids
- Avoid within 30 minutes of Sucralfate
- Sucralfate requires an acidic environment to activate (polymerize)
- May interfere with absorption of other drugs (take Sucralfate 2 hours before or after)
X. Resources
- Sucralfate Tablet (DailyMed)
XI. References
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 94
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
Images: Related links to external sites (from Bing)
Related Studies
sucralfate (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
SUCRALFATE 1 GM TABLET | Generic | $0.21 each |
SUCRALFATE 1 GM/10 ML SUSP | Generic | $0.31 per ml |
carafate (on 8/17/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
CARAFATE 1 GM TABLET | Generic | $0.21 each |
CARAFATE 1 GM/10 ML SUSP | Generic | $0.31 per ml |
Ontology: Sucralfate (C0038633)
Definition (NCI) | A nonabsorbable, aluminum salt of sucrose orasulfate with anti-ulcer, mucosa-protective and potentially anti-mucositis activity. Negatively charged sucralfate binds, through ionic bond formation, to positively charged proteins on mucosal surfaces, thereby creating a protective coating and physical barrier. This agent may also enhance the production of prostaglandin E2 locally, thereby promoting mucus production, increasing mucosal blood flow and stimulating epithelial proliferation and may contribute to the healing of damaged mucosa. |
Definition (NCI_NCI-GLOSS) | A drug used to treat ulcers. It adheres to proteins at the ulcer site and forms a protective coating over the ulcer. Sucralfate is also used to treat mucositis. |
Definition (MSH) | A basic aluminum complex of sulfated sucrose. |
Concepts | Pharmacologic Substance (T121) , Carbohydrate (T118) |
MSH | D013392 |
SnomedCT | 387387008, 69967001 |
LNC | LP171641-6 |
English | Aluminum Sucrose Sulfate, Basic Aluminum Sucrose Sulfate, Sucralfate, Sulfate, Aluminum Sucrose, Aluminum, hexadeca-mu-hydroxytetracosahydroxy(mu8-(1,3,4,6-tetra-O-sulfo-beta-D-fructofuranosyl alpha-D-glucopyranoside tetrakis(hydrogen sulfato)(8-)))hexadeca-, sucralfate, sucralfate (medication), SUCRALFATE, Sucralfate [Chemical/Ingredient], Basic aluminum sucrose sulfate, Sucralfate (product), Sucralfate (substance), Basic aluminium sucrose sulphate |
Swedish | Sukralfat |
Czech | sukralfát |
Finnish | Sukralfaatti |
Russian | ALIUMINIIA SAKHAROZOSUL'FAT, SUKRALFAT, АЛЮМИНИЯ САХАРОЗОСУЛЬФАТ, СУКРАЛФАТ |
Japanese | スクラルファート, スクラルフェート, 硫酸アルミニウムスクロース |
Croatian | SUKRALFAT |
Polish | Sukralfat |
Spanish | sucralfato (producto), sucralfato (sustancia), sucralfato, sulfato de sacarosa de aluminio básico, Sucralfato, Sulfato de Sacarosa de Aluminio |
French | Sucralfate |
German | Aluminium-Saccharosesulfat, Sucralfat |
Italian | Sucralfato |
Portuguese | Sucralfato, Sulfato de Alumínio Sucrose |