II. Indications
III. Contraindications
-
Hemodialysis (caution)
- Risk of Aluminum accumulation
IV. Mechanism
- Sucralfate is a nonabsorbable, aluminum salt of sucrose orasulfate
- Polymerizes atlow pH (e.g. Stomach acid)
- Sucralfate is negatively charged and binds positively charged Proteins on mucosal surface
- Creates a protective coating that overlies the mucosa, and prevents mucositis and Peptic Ulcer formation
- May also stimulate mucus production by triggering local Prostaglandin E2 release
V. Dosing
- Adult
- Take 1 gram orally four times daily at one hour before meals and at bedtime
- May decrease to twice daily for maintenance therapy
- Child (off label)
- Age <6 years
- Give 40 to 80 mg/kg/day divided four times daily up to 500 mg orally every 6 hours
- Age >6 years
- Give 1 gram orally four times daily at one hour before meals and at bedtime
- Age <6 years
VI. Adverse Effects
VII. Safety
- Pregnancy Category B
- Unknown safety in Lactation
VIII. Pharmacokinetcs
- Absorption of only 3 to 5%
IX. Drug Interactions
-
Antacids
- Avoid within 30 minutes of Sucralfate
- Sucralfate requires an acidic environment to activate (polymerize)
- May interfere with absorption of other drugs (take Sucralfate 2 hours before or after)
X. Resources
- Sucralfate Tablet (DailyMed)
XI. References
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 94
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
Images: Related links to external sites (from Bing)
Related Studies
| sucralfate (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| SUCRALFATE 1 GM TABLET | Generic | $0.21 each |
| SUCRALFATE 1 GM/10 ML SUSP | Generic | $0.31 per ml |
| carafate (on 8/17/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CARAFATE 1 GM TABLET | Generic | $0.21 each |
| CARAFATE 1 GM/10 ML SUSP | Generic | $0.31 per ml |