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Ontology:
Bisacodyl
(C0005632)
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Definition (NCI)
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A synthetic pyridinylmethylene-diacetate ester derivative stimulant laxative, Bisacodyl acts with a parasympathetic effect directly on mucosal sensory nerves, increasing peristaltic contractions. It is used for occasional constipation, in pre- and postoperative treatment, and in conditions that require facilitation of defecation. (NCI04)
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|
Definition (MSH)
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A diphenylmethane stimulant laxative used for the treatment of constipation and for bowel evacuation. (From Martindale, The Extra Pharmacopoeia, 30th ed, p871)
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
| MSH |
D001726
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| SnomedCT |
391851004, 13565005, 387075009 |
| LNC |
LP14916-8, MTHU002176 |
| English |
Bisacodyl, Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester), bisacodyl (medication), bisacodyl, Bisacodyl [Chemical/Ingredient], BISACODYL, Bisacodyl - chemical (substance), Bisacodyl - chemical, Bisacodyl (product), Bisacodyl (substance), Bisacodyl, NOS |
| Swedish |
Bisakodyl
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| Czech |
bisakodyl
|
| Finnish |
Bisakodyyli
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| Russian |
BISAKODIL, БИСАКОДИЛ |
| Japanese |
ビサコジル
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| Polish |
Bisakodyl
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| Spanish |
bisacodilo (producto), bisacodilo (sustancia), bisacodilo, Bisacodilo |
| French |
Bisacodyl
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| German |
Bisacodyl
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| Italian |
Bisacodil
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| Portuguese |
Bisacodil
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Ontology:
Senna Extract
(C0036656)
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Definition (NCI)
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An extract made from the dried leaflets on the pods of Cassia angustifolia or Cassia acutifolia with cathartic activity. Dimeric glycosides in dried senna extract are converted to the active monoanthrones by bacterial action in the colon. Through direct effects on enterocytes, enteric neurons, and muscle, monoanthrones produce giant migrating colonic contractions in addition to water and electrolyte secretion. As do other stimulant laxatives, monoanthrones may induce a limited low-grade inflammation in the colon through activation of prostaglandin/cyclic AMP and nitric oxide/cyclic GMP pathways and perhaps inhibition of Na+, K+-ATPase.
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Definition (MSH)
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Preparations of Cassia senna and C. angustifolia (see SENNA PLANT). They contain sennosides, which are anthraquinone type CATHARTICS and are used in many different preparations as laxatives.
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Definition (PDQ)
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An extract made from the dried leaflets on the pods of Cassia angustifolia or Cassia acutifolia with laxative properties. Dimeric glycosides in dried senna extract are converted to the active monoanthrones by bacterial action in the colon. Through direct effects on enterocytes, enteric neurons, and muscle, monoanthrones produce giant migrating colonic contractions in addition to water and electrolyte secretion. As do other stimulant laxatives, monoanthrones may induce a limited low-grade inflammation in the colon through activation of prostaglandin/cyclic AMP and nitric oxide/cyclic GMP pathways and perhaps inhibition of Na+, K+-ATPase. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=480408&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=480408&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61324" NCI Thesaurus)
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D012676
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| Swedish |
Sennaextrakt
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| English |
senna extract, Senna Extract [Chemical/Ingredient], Senna Extract, Extract, Senna, SENNA EXTRACT |
| Czech |
senna - extrakt
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| Finnish |
Sennauute
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| Russian |
SENNY EKSTRAKT, СЕННЫ ЭКСТРАКТ |
| Japanese |
セノコット, ヨーデルS, ヨーヤクール, アジャストA, センナエキス |
| Polish |
Wyciąg z senesu
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| Portuguese |
Extrato de Sene, Extrato de Cene, Extrato de Cássia, Extrato de Sena |
| French |
Extrait de séné
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| German |
Senna-Extrakt
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| Italian |
Estratto di Senna
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| Spanish |
Extracto de Senna
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Ontology:
Cascara sagrada
(C0205704)
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Definition (MSH)
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Dried aged bark of a buckthorn, Frangula purshiana (FRANGULA), that contains the anthraquinone EMODIN and cascarosides. It is used as a laxative (CATHARTICS).
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| Concepts |
Organic Chemical
(T109)
, Pharmacologic Substance
(T121)
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| MSH |
D002362
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| SnomedCT |
23888001, 387128007 |
| English |
Cascara, Cascara sagrada, Sacred Bark, cascara sagrada, laxatives cascara sagrada, cascara sagrada (medication), Cascara Sagrada Fluid Extract, cascara sagrada fluid extract, Cascara Sagrada, CASCARA SAGRADA FLUID EXTRACT, CASCARA SAGRADA @ @ FLUID EXTRACT, Cascara [Chemical/Ingredient], cascara sagrada extract, cascara, Cascara (product), Cascara (substance), CASCARA SAGRADA ORAL FLUID EXTRACT, CASCARA SAGRADA@@ORAL@FLUID EXTRACT, CASCARA SAGRADA, CASCARA SAGRADA EXTRACT |
| Portuguese |
Cáscara
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| Swedish |
Sagrada
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| Czech |
kaskara
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| Finnish |
Sagradankuori
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| Italian |
Cascara sagrada, Cascara |
| Russian |
KAZANTRANOL, KASKARA, CASANTHRANOL, КАЗАНТРАНОЛ, КАСКАРА |
| Japanese |
カスカラ, カスカラサグラダ, カサントラノール |
| French |
Écorce sacrée, Cascara |
| Polish |
Kaskara
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| Spanish |
cáscara (producto), cáscara (sustancia), cáscara sagrada, cáscara, Cáscara |
| German |
Cascara
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Ontology:
Casanthranol
(C0205705)
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Definition (NCI)
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A concentrated mixture of anthranol glycosides from cascara sagrada (dried bark of Rhamnus p.) and used as a laxative in constipation and various medical conditions, stimulant laxative Casanthranol encourages bowel movements by acting on the intestinal wall to increase muscle contractions. (NCI04)
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Definition (MSH)
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A concentrated mixture of anthranol glycosides derived from cascara sagrada.
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D002362
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| SnomedCT |
116530002, 400300006 |
| LNC |
LP171651-5 |
| English |
casanthranol, casanthranol (medication), laxatives casanthranol, Casanthranol [Chemical/Ingredient], Casanthranol (product), Casanthranol (substance), Casanthranol, CASANTHRANOL |
| Portuguese |
Casantranol
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| Spanish |
Casantranol, casantranol (producto), casantranol (sustancia), casantranol |
| German |
Casanthranol
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| French |
Casanthranol
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| Italian |
Casanthranol
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Ontology:
Melanosis coli
(C0221391)
| Concepts |
Disease or Syndrome
(T047)
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| SnomedCT |
11256005
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| English |
Melanosis coli, melanosis coli (diagnosis), melanosis coli, colon melanosis, melanosis of colon, melanosis, coli melanosis, Colonic pseudomelanosis, Melanosis of colon, Melanosis coli (disorder), colon; melanosis, melanosis; colon |
| Italian |
Melanosi del colon
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| Japanese |
結腸メラノーシス, ｹｯﾁｮｳﾒﾗﾉｰｼｽ |
| Czech |
Střevní melanóza
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| Hungarian |
Melanosis coli
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| Dutch |
colon; melanose, melanose; colon, melanosis coli |
| Spanish |
melanosis coli (trastorno), melanosis coli, melanosis del colon, seudomelanosis colónica, Melanosis del colon |
| Portuguese |
Melanose do cólon
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| French |
Mélanose colique
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| German |
Melanosis coli
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Ontology:
Stimulant laxative
(C0304553)
| Concepts |
Pharmacologic Substance
(T121)
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| SnomedCT |
317511006, 56762002 |
| English |
Stimulant laxative, STIMULANT LAXATIVES, [GA204] STIMULANT LAXATIVES, stimulant laxatives, laxatives stimulant, laxative stimulants, laxative stimulant, stimulant laxative, Stimulant laxatives, Stimulant laxative (substance), Stimulant laxatives (product), Stimulant laxative, NOS, Stimulant laxatives (substance) |
| Spanish |
laxante estimulante (sustancia), laxante estimulante, laxantes estimulantes (producto), laxantes estimulantes |
Ontology:
Diphenylmethane laxative
(C0304558)
| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| SnomedCT |
61939007, 387345006 |
| English |
Diphenylmethane laxative (product), Diphenylmethane laxative (substance), Diphenylmethane laxative, Diphenylmethane laxative, NOS |
| Spanish |
laxante de difenilmetano (producto), laxante de difenilmetano (sustancia), laxante de difenilmetano |
Ontology:
Peri-Colace
(C0307257)
| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| English |
Peri-Colace, peri colace, peri-colace, Peri-Colace (obsolete) |
Ontology:
Anthraquinone laxative
(C0360063)
| Concepts |
Pharmacologic Substance
(T121)
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| SnomedCT |
74780007, 387424000 |
| English |
Anthraquinone laxatives, Anthraquinone laxative (product), Anthraquinone laxative (substance), Anthraquinone laxative, Anthraquinone laxative, NOS |
| Spanish |
laxante de antraquinona (producto), laxante de antraquinona (sustancia), laxante de antraquinona |
Ontology:
Phenolphthalein
(C0600489)
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Definition (NCI)
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An organic compound used as a laboratory reagent and pH indicator. Phenolphthalein exerts laxative effects by stimulating the intestinal mucosa and constricting smooth muscles. However, phenolphthalein is no longer used as a laxative due to the suspected carcinogenicity of this compound.
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Definition (MSH)
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An acid-base indicator which is colorless in acid solution, but turns pink to red as the solution becomes alkaline. It is used medicinally as a cathartic.
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| Concepts |
Pharmacologic Substance
(T121)
, Indicator, Reagent, or Diagnostic Aid
(T130)
, Organic Chemical
(T109)
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| MSH |
D020113
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| SnomedCT |
255671009, 19595005, 398955002 |
| LNC |
LP14911-9, MTHU002165 |
| English |
phenolphthalein, Phenolphthalein, 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxyphenyl)-, phenolphthalein (medication), laxatives phenolphthalein, 3,3-Bis(4-hydroxyphenyl)-1(3H)-isobenzofuranone, 3,3-Bis(p-hydroxyphenyl)phthalide, Phenolphthalein [Chemical/Ingredient], Phenolphthalein (product), Phenolphthalein (substance), PHENOLPHTHALEIN, PHENOLPHTHALEIN,WHITE, PHENPOLPHTHALEIN |
| Swedish |
Fenolftalein
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| Czech |
fenolftalein
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| Finnish |
Fenolftaleiini
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| Russian |
FENOLFTALEIN, ФЕНОЛФТАЛЕИН |
| Japanese |
フェノールフタレイン
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| Polish |
Fenoloftaleina
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| Spanish |
fenolftaleína (producto), fenolftaleína (sustancia), fenolftaleína, Fenolftaleína |
| French |
Phénolphtaléine
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| German |
Phenolphthalein
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| Italian |
Fenolftaleina
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| Portuguese |
Fenolftaleína
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Ontology:
Correctol laxative
(C0618983)
| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
C038509
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| English |
Correctol laxative, Correctol (obsolete), Correctol Capl (obsolete) |
Ontology:
Senokot
(C0699932)
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Definition (NCI)
|
A standardized, concentrated preparation, by Purdue, containing the anthraquinone glycosides sennosides extracted from senna leaves with laxative activity. Sennosides act on and irritate the lining of the intestine wall, thereby causing increased intestinal muscle contractions leading to vigorous bowel movement.
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
| MSH |
C002839
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| English |
Senokot, senokot |
Ontology:
Ex-Lax
(C0720319)
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Definition (NCI)
|
A commercial preparation, by Novartis, with laxative activity. Ex-Lax contains anthraquinone glycosides sennosides, extracted from senna leaves. Sennosides irritate the lining of the intestine wall, thereby causing increased intestinal muscle contractions that lead to vigorous bowel movement and relief constipation.
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
| MSH |
D020113
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| English |
ex-lax, ex lax, Ex-Lax, Manesco Brand of Phenolphthalein, Novartis Brand of Phenolphthalein |
