II. Medications: Laxatives
-
Bulk Laxative (Fiber Supplementation, Preferred agents)
- Preferred agents (effective with few adverse effects)
- Psyllium (e.g. Metamucil)
- Methylcellulose (e.g. Citrucel)
- Calcium Polycarbophil (Fibercon)
- Dietary Fiber
-
Osmotic Laxative (Preferred agents)
- Poorly absorbed saccharides (Lactulose, Sorbitol)
- Magensium Laxatives (Milk of Magnesia)
- Sodium bisphosphate (Fleets Phospho-Soda)
- Polyethylene Glycol lavage solution (GoLytely)
- Emollient Laxative (Stool Softener)
-
Stimulant Laxative (Risk of Laxative abuse)
- Other Laxative types are preferred over these
- Anthraquinone Laxative
- Cascara Sagrada Extract (Casanthranol)
- Senna Extract (Senokot)
- Diphenylmethane Laxative
- Bisacodyl (Dulcolax)
- Phenolphthalein (OTC, Correctol, Ex-Lax)
- Combination Agents
- Peri-Colace contains Cascara and Docusate
- Senekot-S contains senna and Docusate
III. Medications: Enemas and suppositories
- Precautions
- Never use hot water, soap, or Hydrogen Peroxide enema
- Tap water enema or saline enema (safest)
- Sodium Bisphosphate enema (Fleet Enema)
- Pink Lady Enema (1/2 Fleet Enema, 100 ml Docusate, 60 ml Mineral Oil, 60 ml Magnesium Citrate)
- Mineral Oil Enema
- Glycerine suppository
- Bisacodyl suppository (Dulcolax suppository)
IV. Medications: Prokinetic agents
- See Constipation Dominant Irritable Bowel Syndrome
- Secretagogoues
- Linaclotide
- Plecanatide
- Lubriprostone
- Tenapanor
- Prokinetic Agents
- Prucalopride
- Tegaserod (Zelnorm)
- Withdrawn from U.S. market in 2007 due to Cardiovascular Risks (but still available for limited use)
- Indicated only in IBS for Constipation in women
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Related Studies
| laxative (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| LAXATIVE EC 5 MG TABLET | Generic OTC | $0.03 each |
Ontology: Laxatives (C0282090)
| Definition (CHV) | a drug used to treat constipation by increasing bowel movement |
| Definition (CHV) | a drug used to treat constipation by increasing bowel movement |
| Definition (NCI) | Synthetic compounds or mixtures administered orally or rectally with laxative activity. A laxative preparation is used to promote bowel movement to treat constipation or to clean the colon for rectal and bowel examinations. There are different types of laxatives that differ in mechanism of action and potency, including the bulk-producing agents, stool softeners, lubricants, hydrating agents, stimulants, saline laxatives and hyperosmotic agents. |
| Definition (NCI_NCI-GLOSS) | A substance that promotes bowel movements. |
| Definition (CSP) | agent that acts to promote evacuation of the bowel; a cathartic or purgative. |
| Definition (MSH) | Agents that produce a soft formed stool, and relax and loosen the bowels, typically used over a protracted period, to relieve CONSTIPATION. |
| Concepts | Pharmacologic Substance (T121) |
| MSH | D054368 |
| SnomedCT | 317640001, 372800002, 61621000 |
| LNC | LP18988-3, MTHU007218 |
| English | Other laxatives, LAXATIVES,OTHER, LAXATIVES, Laxatives, laxatives (medication), laxatives, GI preparations laxatives, Laxative Preparation, [GA209] LAXATIVES,OTHER, [GA200] LAXATIVES, laxative, Other laxatives (product), Laxative, Laxative (product), Laxative (substance), Laxative, NOS, Other laxatives (substance), Mild cathartic |
| Portuguese | Laxantes, Laxativos |
| Spanish | Laxativos, otros laxantes, otros laxantes (producto), Laxantes, laxante (producto), laxante (sustancia), laxante |
| Finnish | Ulostuslääkkeet |
| French | Agents laxatifs, Médicaments laxatifs, Laxatifs |
| German | Laxantien |
| Italian | Lassativi |
| Russian | LAKSATIVY, ЛАКСАТИВЫ |
| Czech | projímadla, laxancia, laxativa |
| Swedish | Avföringsmedel |
| Polish | Leki przeczyszczające |
| Japanese | 緩下剤, 緩下薬 |
