III. Contraindications

  1. Mechanical Bowel Obstruction
  2. Children (esp. age <6 years)

IV. Mechanism

  1. Guanylate cyclase-c Agonist
  2. Induces cGMP mediated chloride and bicarbonate secretion into bowel lumen; Sodium and water follow
    1. Results in gastrointestinal fluid secretion into the bowel lumen (secretagogue)

V. Dosing

  1. Take 290 mcg orally daily at least 30 minutes before first meal of the day
  2. May be given by Nasogastric Tube via opened capsule and mixed with 30 ml water

VI. Efficacy

  1. May improve stool frequency, consistency and straining in Irritable Bowel Syndrome
  2. Marginal efficacy (NNT 5-8) for decreased Abdominal Pain

VII. Adverse Effects

VIII. Safety

  1. Pregnancy Category C
  2. Unknown safety in Lactation

IX. Drug Interactions

  1. No known Drug Interactions

XI. References

  1. (2012) Prescr Lett 19(12): 68-9
  2. (2021) Irritable Bowel Syndrome Drug Comparison, Presc Lett, #370305
  3. (2020) Med Lett Drugs Ther 62(1594): 41-58

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Related Studies

Cost: Medications

linzess (on 1/14/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
LINZESS 145 MCG CAPSULE $15.71 each
LINZESS 290 MCG CAPSULE $15.69 each
LINZESS 72 MCG CAPSULE $15.70 each