II. Definitions
- Allergic Triad (Samter's Triad)
- Allergic Constellation centered around Aspirin (or NSAID) allergy or sensitivity
- Associated with Nasal Polyps and Eosinophilic Asthma (T2 Asthma)
III. Pathophysiology
- Associated with disordered Arachidonic Acid metabolism (cyclooxygenase mediated to inflammatory agents)
IV. Associated Conditions
- Aspirin-induced Asthma
- Rhinorrhea
- Nasal Polyps
- Chronic Sinusitis
- Conjunctival edema
V. Course
- Onset as perennial Vasomotor Rhinitis
- Develops into hyperplastic Rhinosinusitis, Nasal Polyps
- Asthma is typically severe from onset with frequent exacerbations
VI. Causes
- Aspirin
- Cross-reactivity with NSAIDs
- Indomethacin
- Naproxen
- Ibuprofen
- Fenoprofen
- Mefenamic Acid
- Phenylbutazone
VII. Labs: Markers
- See Extrinsic Asthma
- Associated with increased urinary LTE4 > 166 pg/mgCr
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Related Studies
| Concepts | Disease or Syndrome (T047) |
| Dutch | Samter-syndroom |
| French | Syndrome de Samter |
| German | Widal'sche Trias |
| Italian | Sindrome di Samter |
| Portuguese | Síndrome de Samter |
| Spanish | Síndrome de Samter |
| Japanese | サムター症候群, ｻﾑﾀｰｼｮｳｺｳｸﾞﾝ |
| Czech | Samterův syndrom |
| Hungarian | Samter-syndroma |
| English | Samter's syndrome |
