Mefenamic Acid

Aka: Mefenamic Acid, Ponstel

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II. Indications

  1. See NSAID
  2. FDA approved indications in Adults (or age >14 years old)
    1. Primary Dysmenorrhea
    2. Mild to moderate pain

III. Contraindications

  1. See NSAID

IV. Mechanism

  1. See NSAID
  2. Anthranilic Acid NSAID in the Fenamate Class

V. Medications

  1. Mefenamic Acid capsules 250 mg

VI. Dosing: Adults

  1. Dysmenorrhea: Initial 500 mg orally, then 250 mg orally every 6 hours for up to 1 week

VII. Adverse Effects

  1. See NSAID

VIII. Safety

  1. See NSAID
  2. Avoid in Lactation
  3. Avoid NSAIDs in pregnancy outside the first part of the second trimester (13 to 20 weeks)
    1. Teratogenic in first trimester
    2. Risk of premature ductus arteriosus closure in the fetus in third trimester
    3. Most NSAIDs carry a legacy system Pregnancy Category B or C designation (aside from third trimester)
      1. However, many obstetricians avoid NSAIDs entirely in pregnancy (even in second trimester)

IX. Resources

  1. Mefenamic Acid (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4c275df4-f044-4867-8498-f46d34103bbb

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