Mefenamic Acid

Aka: Mefenamic Acid, Ponstel

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II. Indications

  1. See NSAID
  2. FDA approved indications in Adults (or age >14 years old)
    1. Primary Dysmenorrhea
    2. Mild to moderate pain

III. Contraindications

  1. See NSAID

IV. Mechanism

  1. See NSAID
  2. Anthranilic Acid NSAID in the Fenamate Class

V. Medications

  1. Mefenamic Acid capsules 250 mg

VI. Dosing: Adults

  1. Dysmenorrhea: Initial 500 mg orally, then 250 mg orally every 6 hours for up to 1 week

VII. Adverse Effects

  1. See NSAID

VIII. Safety

  1. See NSAID
  2. Avoid in Lactation
  3. Avoid NSAIDs in pregnancy outside the first part of the second trimester (13 to 20 weeks)
    1. Teratogenic in first trimester
    2. Risk of premature ductus arteriosus closure in the fetus in third trimester
    3. Most NSAIDs carry a legacy system Pregnancy Category B or C designation (aside from third trimester)
      1. However, many obstetricians avoid NSAIDs entirely in pregnancy (even in second trimester)

IX. Resources

  1. Mefenamic Acid (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4c275df4-f044-4867-8498-f46d34103bbb

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Related Studies

Cost: Medications

mefenamic acid (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
MEFENAMIC ACID 250 MG CAPSULE Generic $1.49 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Ontology: Mefenamic Acid (C0025152)

Definition (NCI) An anthranilic acid and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Mefenamic acid inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of mefenamic acid. Mefenamic acid also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.
Definition (MSH) A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008528
SnomedCT 329789005, 322296007, 363613004, 34364009, 387185008
English Acid, Mefenamic, Acid, Mefenaminic, Mefenamic Acid, Mefenaminic Acid, Benzoic acid, 2-((2,3-dimethylphenyl)amino)-, Mefenamic acid [cns analges], Mefenamic acid [cns analgesic] [see j2b..], Mefenamic acid [musculo-skel], Anthranilic Acid, N-2,3-xylyl-, 2-((2,3-Dimethylphenyl)amino)benzoic Acid, Mefenamic acid [musculoskeletal use], mefenamic acid (medication), Mefenamic Acid [Chemical/Ingredient], acid mefenamic, mefanamic acid, MEFENAMIC ACID, Mefenamic acid [cns analgesic] [see j2b..] (product), Mefenamic acid product (substance), Mefenamic acid [musculoskeletal use] (product), Mefenamic acid product, mefenamic acid, Mefenamic acid, Mefenamic acid (product), Mefenamic acid (substance), Mefenamic acid [cns analgesic] [see j2b..] (substance), Mefenamic acid [musculoskeletal use] (substance)
Swedish Mefenamsyra
Czech kyselina mefenamová
Finnish Mefenaamihappo
Russian MEFENAMOVAIA KISLOTA, МЕФЕНАМОВАЯ КИСЛОТА
Japanese ポンタール, ワンメデー, バファメリチンM, マイカサール, ルメンタール, ボナボール, メフェナム酸, ヨウフェナム, ノイリトール
Polish Kwas mefenaminowy
Spanish ácido mefenámico [uso musculoesquelético] (producto), ácido mefenámico [analgésico de acción central] [véase j2b..] (producto), ácido mefenámico [uso musculoesquelético], ácido mefenámico [analgésico de acción central] [véase j2b..], ácido mefenámico (producto), ácido mefenámico (sustancia), ácido mefenámico, Ácido Mefenámico
French Acide méfénamique
German Mefenaminsäure
Italian Acido mefenamico
Portuguese Ácido Mefenâmico
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Analgesic Medications

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