Mefenamic Acid

Aka: Mefenamic Acid, Ponstel

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II. Indications

  1. See NSAID
  2. FDA approved indications in Adults (or age >14 years old)
    1. Primary Dysmenorrhea
    2. Mild to moderate pain

III. Contraindications

  1. See NSAID

IV. Mechanism

  1. See NSAID
  2. Anthranilic Acid NSAID in the Fenamate Class

V. Medications

  1. Mefenamic Acid capsules 250 mg

VI. Dosing: Adults

  1. Dysmenorrhea: Initial 500 mg orally, then 250 mg orally every 6 hours for up to 1 week

VII. Adverse Effects

  1. See NSAID

VIII. Safety

  1. See NSAID
  2. Avoid in Lactation
  3. Avoid NSAIDs in pregnancy outside the first part of the second trimester (13 to 20 weeks)
    1. Teratogenic in first trimester
    2. Risk of premature ductus arteriosus closure in the fetus in third trimester
    3. Most NSAIDs carry a legacy system Pregnancy Category B or C designation (aside from third trimester)
      1. However, many obstetricians avoid NSAIDs entirely in pregnancy (even in second trimester)

IX. Resources

  1. Mefenamic Acid (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4c275df4-f044-4867-8498-f46d34103bbb

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Related Studies

Cost: Medications

mefenamic acid (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
MEFENAMIC ACID 250 MG CAPSULE Generic $1.49 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Analgesic Medications

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