Celecoxib

Aka: Celecoxib, Celebrex

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II. Class

  1. NSAID: COX2 Inhibitor
  2. Similar to Rofecoxib (Vioxx)
  3. Diaryl-substituted pyrazole

III. Advantages

  1. Less gastrointestinal adverse effects than other NSAIDs
    1. See NSAID Gastrointestinal Adverse Effects

IV. Metabolism

  1. Oral Bioavailability: 22 to 40%
  2. Half Life: 11 hours
  3. Liver metabolism by Cytochrome P450: CYP2C9
    1. Levels raised with Accolate, Diflucan, and Lescol
  4. Inhibits Cytochrome P450: CYP2D6
    1. Increases levels of Beta Blockers and psychotropics

V. Contraindications: Sulfonamide Allergy

  1. Consider alternative agent: Rofecoxib (Vioxx)

VI. Dosing

  1. Osteoarthritis: 200 mg PO qd (or 100 mg po bid)
  2. Rheumatoid Arthritis: 200 mg PO qd to bid
  3. Familial Adenoma Polyposis: 400 mg PO bid

VII. Adverse Effects

  1. Celebrex appears safer than Ibuprofen in terms of cardiovascular risk
    1. Ruschitzka (2017) Eur Heart J +PMID:29020251 [PubMed]
  2. Abdominal Pain
  3. Diarrhea
  4. Dyspepsia
  5. Peptic Ulcer Disease risk (see COX2 Inhibitor)
  6. Does not increase Bleeding Time

VIII. References

  1. Michalets (1998) Pharmacotherapy 18:84 [PubMed]
  2. (1999) Med Lett Drugs Ther 41(1045): 11-14 [PubMed]

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Related Studies

Cost: Medications

celecoxib (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
CELECOXIB 100 MG CAPSULE Generic $0.46 each
CELECOXIB 200 MG CAPSULE Generic $0.44 each
CELECOXIB 400 MG CAPSULE Generic $1.96 each
CELECOXIB 50 MG CAPSULE Generic $0.35 each
celebrex (on 1/1/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
CELEBREX 100 MG CAPSULE Generic $0.46 each
CELEBREX 200 MG CAPSULE Generic $0.44 each
CELEBREX 400 MG CAPSULE Generic $1.96 each
CELEBREX 50 MG CAPSULE Generic $0.35 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Ontology: celecoxib (C0538927)

Definition (CHV) a drug used to treat pain and inflammation
Definition (NCI) A nonsteroidal anti-inflammatory drug (NSAID) with a diaryl-substituted pyrazole structure. Celecoxib selectively inhibits cyclo-oxygenase-2 activity (COX-2); COX-2 inhibition may result in apoptosis and a reduction in tumor angiogenesis and metastasis.
Definition (NCI_NCI-GLOSS) A drug that reduces pain. Celecoxib belongs to the family of drugs called nonsteroidal anti-inflammatory agents. It is being studied in the prevention of cancer.
Definition (PDQ) A nonsteroidal anti-inflammatory drug (NSAID) with a diaryl-substituted pyrazole structure. Celecoxib selectively inhibits cyclo-oxygenase-2 activity (COX-2); COX-2 inhibition may result in apoptosis and a reduction in tumor angiogenesis and metastasis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43023&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43023&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1728" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C105934
SnomedCT 370187009, 330166009, 116081000
LNC LP28519-4, MTHU013163
English 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, celecoxib, celecoxib (medication), CELECOXIB, celecoxib [Chemical/Ingredient], Celecoxib (product), Benzenesulfonamide, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-, Celecoxib (substance), Celecoxib product (product), Celecoxib product, Celecoxib
Spanish celecoxib (producto), producto con celecoxib (producto), celecoxib, producto con celecoxib, Celecoxib (sustancia), Celecoxib
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Celebrex (C0719198)

Definition (CHV) a kind of arthritis drug
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C105934
English Celebrex, CeleBREX, celebrex, Pfizer brand of celecoxib
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Analgesic Medications

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