II. Class
- NSAID: COX2 Inhibitor
- Similar to Rofecoxib (Vioxx)
- Diaryl-substituted pyrazole
III. Advantages
- Less gastrointestinal adverse effects than other NSAIDs
IV. Metabolism
- Oral Bioavailability: 22 to 40%
- Half Life: 11 hours
- Liver metabolism by Cytochrome P450: CYP2C9
- Inhibits Cytochrome P450: CYP2D6
- Increases levels of Beta Blockers and psychotropics
VI. Dosing
- Osteoarthritis: 200 mg PO qd (or 100 mg po bid)
- Rheumatoid Arthritis: 200 mg PO qd to bid
- Familial Adenoma Polyposis: 400 mg PO bid
VII. Adverse Effects
- Celebrex appears safer than Ibuprofen in terms of cardiovascular risk
- Abdominal Pain
- Diarrhea
- Dyspepsia
- Peptic Ulcer Disease risk (see COX2 Inhibitor)
- Does not increase Bleeding Time
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Related Studies
| celecoxib (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CELECOXIB 100 MG CAPSULE | Generic | $0.10 each |
| CELECOXIB 200 MG CAPSULE | Generic | $0.11 each |
| CELECOXIB 400 MG CAPSULE | Generic | $0.49 each |
| CELECOXIB 50 MG CAPSULE | Generic | $0.13 each |
| celebrex (on 3/15/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CELEBREX 200 MG CAPSULE | Generic | $0.11 each |