Sulindac

Aka: Sulindac, Clinoril

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II. Indications

  1. See NSAID
  2. FDA Approved Indications in adults
    1. Rheumatoid Arthritis
    2. Osteoarthritis
    3. Acuty Gouty Arthritis
    4. Musculoskeletal pain (Bursitis, Tendinitis)

III. Contraindications

  1. See NSAID

IV. Mechanism

  1. See NSAID
  2. NSAID in the acetic acid class (indole)

V. Medications

  1. Sulindac (Clinoril): 150 mg, 200 mg

VI. Dosing

  1. Adult
    1. Sulindac (Clinoril) 150 to 200 mg orally twice daily
    2. Maximum: 200 mg/day
  2. Child (not FDA approved, off-label)
    1. Juvenile Rheumatoid Arthritis: 4 mg/kg/day orally divided twice daily

VII. Adverse Effects

  1. See NSAID
  2. Drug-Induced Pancreatitis
    1. However, Sulindac has also been investigated for the management of Chronic Pancreatitis
    2. Sugerman (1989) Am Surg 55(9):536-8 +PMID: 2774359 [PubMed]
    3. Bai (2012) BMC Gastroenterol 12:115 +PMID: 22920325 [PubMed]
  3. Hypersensitivity Reaction (severe, life threatening)
    1. Jett GK (1984) Ann Emerg Med 13(6):462-4 +PMID: 6731964 [PubMed]

VIII. Safety

  1. See NSAID
  2. Avoid in Lactation
  3. Avoid NSAIDs in pregnancy outside the first part of the second trimester (13 to 20 weeks)
    1. Teratogenic in first trimester
    2. Risk of premature ductus arteriosus closure in the fetus in third trimester
    3. Most NSAIDs carry a legacy system Pregnancy Category B or C designation (aside from third trimester)
      1. However, many obstetricians avoid NSAIDs entirely in pregnancy (even in second trimester)

IX. Resources

  1. Sulindac (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=96c73bd2-4577-487d-a642-bd8f91e94c3a

X. References

  1. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Cost: Medications

sulindac (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
SULINDAC 150 MG TABLET Generic $0.18 each
SULINDAC 200 MG TABLET Generic $0.21 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Analgesic Medications

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