Nabumetone

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Page Contents

NSAID

Page Contents...
Indications
Contraindications
Mechanism
Medications
Dosing: Adults
Adverse Effects
Safety
Resources
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II. Indications

See NSAID
FDA Approved Indications in Adults
1. Rheumatoid Arthritis
2. Osteoarthritis

III. Contraindications

See NSAID

IV. Mechanism

See NSAID
Nabumetone is a prodrug
1. Undergoes hepatic catalysis, converting it to the active (6-methoxy-2-naphthylacetic acid)
2. 6MNA is partially COX2-selective

V. Medications

Nabumetone tablets 500 mg, 750 mg, 1000 mg

VI. Dosing: Adults

Arthritis (OA, RA)
1. Start: 1000 mg orally daily (or divided twice daily)
2. May titrate to 1500 to 2000 mg orally daily (or divided twice daily)

VII. Adverse Effects

See NSAID

VIII. Safety

See NSAID
Avoid in Lactation
Avoid NSAIDs in pregnancy outside the first part of the second trimester (13 to 20 weeks)
1. Teratogenic in first trimester
2. Risk of premature ductus arteriosus closure in the fetus in third trimester
3. Most NSAIDs carry a legacy system Pregnancy Category B or C designation (aside from third trimester)
  1. However, many obstetricians avoid NSAIDs entirely in pregnancy (even in second trimester)

IX. Resources

Nabumetone
1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ef7c3da8-797f-4ea9-8999-53509785a0f7

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Cost: Medications

nabumetone (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
NABUMETONE 500 MG TABLET	Generic	$0.14 each
NABUMETONE 750 MG TABLET	Generic	$0.19 each

FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.