Nabumetone

Aka: Nabumetone, Relafen

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II. Indications

  1. See NSAID
  2. FDA Approved Indications in Adults
    1. Rheumatoid Arthritis
    2. Osteoarthritis

III. Contraindications

  1. See NSAID

IV. Mechanism

  1. See NSAID
  2. Nabumetone is a prodrug
    1. Undergoes hepatic catalysis, converting it to the active (6-methoxy-2-naphthylacetic acid)
    2. 6MNA is partially COX2-selective

V. Medications

  1. Nabumetone tablets 500 mg, 750 mg, 1000 mg

VI. Dosing: Adults

  1. Arthritis (OA, RA)
    1. Start: 1000 mg orally daily (or divided twice daily)
    2. May titrate to 1500 to 2000 mg orally daily (or divided twice daily)

VII. Adverse Effects

  1. See NSAID

VIII. Safety

  1. See NSAID
  2. Avoid in Lactation
  3. Avoid NSAIDs in pregnancy outside the first part of the second trimester (13 to 20 weeks)
    1. Teratogenic in first trimester
    2. Risk of premature ductus arteriosus closure in the fetus in third trimester
    3. Most NSAIDs carry a legacy system Pregnancy Category B or C designation (aside from third trimester)
      1. However, many obstetricians avoid NSAIDs entirely in pregnancy (even in second trimester)

IX. Resources

  1. Nabumetone
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ef7c3da8-797f-4ea9-8999-53509785a0f7

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Related Studies

Cost: Medications

nabumetone (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
NABUMETONE 500 MG TABLET Generic $0.14 each
NABUMETONE 750 MG TABLET Generic $0.19 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Ontology: nabumetone (C0068334)

Definition (NCI) A naphthylalkanone and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Nabumetone is a prodrug that upon hepatic catalysis converts into the active moiety 6-methoxy-2-naphthylacetic acid (6MNA). 6MNA inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of nabumetone. The formation of thromboxane A2, by thromboxane synthase, is also decreased and results in an inhibition of platelet aggregation.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C035605
SnomedCT 108508000, 363595001, 386859000
LNC LP18093-2, MTHU003376
English 4-(6-methoxy-2-naphthyl)-2-butanone, nabumetone, Nambumetone, 4-(6-Methoxy-2-naphthalenyl)-2-butanone, nabumetone (medication), NABUMETONE, nabumetone [Chemical/Ingredient], nambumetone, nabumeton, Nabumetone product (substance), Nabumetone product, Nabumetone, Nabumetone (product), Nabumetone (substance)
Spanish nabumetona (producto), nabumetona (sustancia), nabumetona
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Analgesic Medications

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