Flurbiprofen

Aka: Flurbiprofen, Ansaid

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II. Indications

  1. See NSAID
  2. FDA approved indications
    1. Rheumatoid Arthritis
    2. Osteoarthritis
  3. Off label use
    1. Ankylosing Spondylitis
    2. Primary Dysmenorrhea
    3. Acute Gout
    4. Acute pain
    5. Juvenile Rheumatoid Arthritis

III. Contraindications

  1. See NSAID

IV. Mechanism

  1. See NSAID
  2. NSAID in the propionic acid class
    1. Other NSAIDS in propionic acid class include Ibuprofen and Naproxen

V. Medications

  1. Flurbiprofen tablets: 50 mg, 100 mg

VI. Dosing

  1. Adults
    1. Arthritis (OA/RA): 200 to 300 mg/day divided twice to four times daily (max single dose: 100 mg)
    2. Primary Dysmenorrhea: 50 mg orally daily
    3. Mild to moderate pain: 50 mg orally every 6 hours
  2. Children (off label, not FDA approved)
    1. Juvenile Rheumatoid Arthritis 4 mg/kg/day divided two to four times daily

VII. Adverse Effects

  1. See NSAID

VIII. Safety

  1. See NSAID
  2. Considered safe in Lactation
  3. Avoid NSAIDs in pregnancy outside the first part of the second trimester (13 to 20 weeks)
    1. Teratogenic in first trimester
    2. Risk of premature ductus arteriosus closure in the fetus in third trimester
    3. Most NSAIDs carry a legacy system Pregnancy Category B or C designation (aside from third trimester)
      1. However, many obstetricians avoid NSAIDs entirely in pregnancy (even in second trimester)

IX. Resources

  1. Flurbiprofen (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4e5c06f1-f279-4f2f-b10d-0f70005a27e6

X. References

  1. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Cost: Medications

flurbiprofen (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
FLURBIPROFEN 0.03% EYE DROP Generic $9.52 per ml
FLURBIPROFEN 100 MG TABLET Generic $0.38 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Analgesic Medications

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