Fenoprofen

Aka: Fenoprofen, Nalfon

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II. Indications

  1. See NSAID
  2. FDA approved indications
    1. Rheumatoid Arthritis
    2. Osteoarthritis

III. Contraindications

  1. See NSAID
  2. Avoid in Renal Insufficiency

IV. Mechanism

  1. See NSAID
  2. NSAID in the propionic acid class
    1. Other NSAIDS in propionic acid class include Ibuprofen and Naproxen

V. Medications

  1. Fenoprofen capsules or tablets: 200 mg, 400 mg, 600 mg

VI. Dosing

  1. Fenoprofen (Nalfon)
    1. Arthritis (OA/RA): 300 to 600 mg orally three to four times daily (max: 3200 mg/day)
    2. Mild to moderate pain: 200 mg every 4 to 6 hours

VII. Adverse Effects

  1. See NSAID
  2. Decreased gastrointestinal adverse effects
  3. Increased genitourinary adverse effects (e.g. Dysuria, Hematuria, nephropathy)
  4. Nephrotoxicity is more than with other NSAIDs
    1. See NSAID Renal Adverse Effects

VIII. Safety

  1. See NSAID
  2. Avoid in Lactation
  3. Avoid NSAIDs in pregnancy outside the first part of the second trimester (13 to 20 weeks)
    1. Teratogenic in first trimester
    2. Risk of premature ductus arteriosus closure in the fetus in third trimester
    3. Most NSAIDs carry a legacy system Pregnancy Category B or C designation (aside from third trimester)
      1. However, many obstetricians avoid NSAIDs entirely in pregnancy (even in second trimester)

IX. Efficacy

  1. Similar to Aspirin (but more potent)

X. Resources

  1. Fenoprofen (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f6f4b654-082a-45ba-9924-41ee9667297a

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