II. Indications
- See NSAID
- FDA approved indications in Adults
- Mild to moderate pain
- Dysmenorrhea
- Menorrhagia
- Osteoarthritis
- Rheumatoid Arthritis
- Non-FDA approved indications in children (off-label use)
III. Contraindications
- See NSAID
V. Medications
- Meclofenamate capsules 50 mg, 100 mg
VI. Dosing: Adults
- Mild to moderate pain
- Meclofenamate 50 mg orally every 4 to 6 hours
- Primary Dymenorrhea
- Meclofenamate 100 mg orally every 8 hours for up to 6 days
-
Arthritis (OA, RA)
- Meclofenamate 200 to 400 mg/day divided 3-4 times daily
VII. Dosing: Child
-
Juvenile Rheumatoid Arthritis (not FDA approved)
- Meclofenamate 3 to 7.5 mg/kg/day (max: 300 mg/day) orally in divided doses
VIII. Adverse Effects
- See NSAID
-
Autoimmune Hemolytic Anemia
- Associated with prolonged use >1 year
-
Diarrhea
- Occurs in up to 35% of patients
IX. Safety
XI. Resources
- Meclofenamate (DailyMed)
XII. References
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
| Definition (NCI) | The sodium salt form of meclofenamate, an anthranilic acid and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Meclofenamate sodium inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of meclofenamate sodium. Meclofenamate sodium also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D008469 |
| SnomedCT | 58233009, 363610001 |
| English | Meclofenamate, Sodium, Sodium Meclofenamate, Sodium, Meclofenamate, Benzoic Acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, Monosodium Salt, Meclonax, Sodium 2-((2,6-dichloro-3-methylphenyl)amino)benzoate, meclofenamate sodium (medication), meclofenamate sodium, MECLOFENAMATE SODIUM, Meclofenamate Sodium, Meclofenamate Sodium [Chemical/Ingredient], Meclofenamate Sodium Salt, Meclofenamate sodium, Meclofenamate sodium (substance), Meclofenamate sodium product (product), Meclofenamate sodium product, Meclofenamate sodium product (substance) |
| German | Natrium-Meclofenamat, Meclofenamat-Natrium |
| Spanish | meclofenamato sódico (producto), meclofenamato sódico, producto (producto), meclofenamato sódico, producto, meclofenamato sódico (sustancia), meclofenamato sódico |
| French | Méclofénamate de sodium |
Ontology: Meclofenamate (C1289957)
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D008469 |
| SnomedCT | 117178002 |
| LNC | LP18481-9, MTHU004498 |
| English | meclofenamate, MECLOFENAMATE, Meclofenamate [Chemical/Ingredient], Meclofenamate (substance), Meclofenamate |
| German | Meclofenamat |
| French | Méclofénamate |
| Spanish | meclofenamato (sustancia), meclofenamato |
