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Definition (NCI)
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A difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. Diflunisal competitively inhibits both cyclooxygenase (COX) -1 and -2, with higher affinity for COX-1, and subsequently blocks the conversion of arachidonic acid to prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. Diflunisal differs from other salicylates, in that it is not metabolized to salicylic acid, hence it has a longer half-life.
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Definition (MSH)
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A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of ASPIRIN.
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D004061
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| SnomedCT |
322291002, 329609003, 363599007, 20865003, 387116004 |
| LNC |
LP18552-7, MTHU004624 |
| English |
Diflunisal, (1,1'-Biphenyl)-3-carboxylic acid, 2',4'-difluoro-4-hydroxy-, diflunisal, Diflunisal [CNS analgesic], Diflunisal [CNS analgesic] [see j23..], Diflunisal [musculo-skel], 2',4'-Difluoro-4-hydroxy-(1,1'-biphenyl)-3-carboxylic Acid, (1,1'-Biphenyl)-3-carboxylic Acid, 2',4'-difluoro-4-hydroxy-, Diflunisal [musculoskeletal use], diflunisal (medication), DIFLUNISAL, Diflunisal [Chemical/Ingredient], Diflunisal [CNS analgesic] [see j23..] (product), Diflunisal [musculoskeletal use] (product), Diflunisal product, Diflunisal product (substance), Difluorophenylsalicylic acid, Diflunisal (product), Diflunisal (substance), Diflunisal [CNS analgesic] [see j23..] (substance), Diflunisal [musculoskeletal use] (substance) |
| Swedish |
Diflunisal
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| Czech |
diflunisal
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| Finnish |
Diflunisaali
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| Russian |
DIFLUNISAL, ДИФЛУНИСАЛ |
| Japanese |
ドロビッド, ジフルニサール, ジフルニサル |
| Polish |
Diflunizal
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| Spanish |
diflunisal [uso musculoesquelético] (producto), diflunisal [analgésico de acción central] [véase j23..], diflunisal [uso musculoesquelético], diflunisal [analgésico de acción central] [véase j23..] (producto), diflunisal (producto), diflunisal (sustancia), diflunisal, ácido difluorofenilsalicílico, Diflunisal |
| French |
Diflunisal
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| German |
Diflunisal
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| Italian |
Diflunisal
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| Portuguese |
Diflunisal
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