Diflunisal

Aka: Diflunisal, Dolobid

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II. Indications

  1. FDA approved indications in adults
    1. Rheumatoid Arthritis
    2. Osteoarthritis
    3. Analgesic in mild to moderate pain

III. Contraindications

  1. See Salicylate

IV. Mechanism

  1. See Salicylate
  2. Difluorophenyl derivate of salicylic acid
  3. Unlike other Salicylates, Diflunisal is not metabolized to salicylic acid
    1. Results in a longer Half-Life than for other Salicylates
  4. As with other Salicylates and NSAIDs, has antipyretic, Analgesic and anti-inflammatory properties
    1. Blocks cyclooxygenase (COX, esp. COX1)
    2. Inhibits conversion of Arachidonic Acid to Prostaglandin precursors
    3. Decreasing Prostaglanding levels results in decreased pain, inflammation and fever

V. Dosing

  1. Diflunisal 250 to 500 mg orally every 8 to 12 hours
  2. Maximum: 1500 mg/day

VI. Adverse Effects

  1. See Salicylate

VII. Safety

  1. See Salicylate
  2. Avoid in Lactation

VIII. Resources

  1. Diflunisal (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7a78bb38-14d8-4a90-b883-482d4cebf716

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Related Studies

Cost: Medications

diflunisal (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
DIFLUNISAL 500 MG TABLET Generic $0.83 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Analgesic Medications

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