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Definition (CHV)
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a kind of nonsteroidal anti-inflammatory drug
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Definition (NCI_NCI-GLOSS)
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A drug that reduces pain, fever, swelling, and redness. It is also being used to reduce tumor-induced suppression of the immune system and to increase the effectiveness of anticancer drugs. It is a type of nonsteroidal anti-inflammatory drug (NSAID).
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Definition (NCI)
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A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. (NCI04)
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Definition (MSH)
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A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
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Definition (CSP)
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non-steroidal anti-inflammatory agent that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids; also inhibits the motility of polymorphonuclear leukocytes.
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Definition (PDQ)
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A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39489&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39489&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C576" NCI Thesaurus)
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D007213
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| SnomedCT |
363607008, 373513008, 60149003 |
| LNC |
LP16167-6, MTHU016716 |
| English |
1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, Indometacin, 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid, indomethacin, Indomethacin, Indomethacin product, indomethacin (medication), INDOMETHACIN, Indomethacin [Chemical/Ingredient], indometacin, Indomethacin product (substance), Indometacin product, Indomethacin (product), Indomethacin (substance), INDO |
| Swedish |
Indometacin
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| Czech |
indomethacin
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| Finnish |
Indometasiini
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| Russian |
METINDOL, INDOMETATSIN, ИНДОМЕТАЦИН, МЕТИНДОЛ |
| Croatian |
INDOMETACIN
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| Polish |
Metindol, Indometacyna |
| Japanese |
インドメサシン, インドメタシン |
| Spanish |
indometacina (producto), indometacina (sustancia), indometacina, Indometacina |
| French |
Indométacine
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| German |
Indometacin
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| Italian |
Indometacina
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| Portuguese |
Indometacina
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