Oxaprozin

Aka: Oxaprozin, Daypro

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II. Indications

  1. See NSAID
  2. FDA approved indications
    1. Rheumatoid Arthritis
    2. Osteoarthritis

III. Contraindications

  1. See NSAID

IV. Mechanism

  1. See NSAID
  2. NSAID in the propionic acid class
    1. Other NSAIDS in propionic acid class include Ibuprofen and Naproxen

V. Medications

  1. Oxaprozin 600 mg scored tablets

VI. Dosing: Adults

  1. Arthritis (RA, OA)
    1. Start 1200 mg orally daily
    2. Maximum dose: 26 mg/kg/day up to 1800 mg/day

VII. Adverse Effects

  1. See NSAID

VIII. Safety

  1. See NSAID
  2. Avoid in Lactation
  3. Avoid NSAIDs in pregnancy outside the first part of the second trimester (13 to 20 weeks)
    1. Teratogenic in first trimester
    2. Risk of premature ductus arteriosus closure in the fetus in third trimester
    3. Most NSAIDs carry a legacy system Pregnancy Category B or C designation (aside from third trimester)
      1. However, many obstetricians avoid NSAIDs entirely in pregnancy (even in second trimester)

IX. Resources

  1. Oxaprozin (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ea1de47e-3101-4414-817c-0a098af8988c

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