Oxaprozin

Aka: Oxaprozin, Daypro

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II. Indications

  1. See NSAID
  2. FDA approved indications
    1. Rheumatoid Arthritis
    2. Osteoarthritis

III. Contraindications

  1. See NSAID

IV. Mechanism

  1. See NSAID
  2. NSAID in the propionic acid class
    1. Other NSAIDS in propionic acid class include Ibuprofen and Naproxen

V. Medications

  1. Oxaprozin 600 mg scored tablets

VI. Dosing: Adults

  1. Arthritis (RA, OA)
    1. Start 1200 mg orally daily
    2. Maximum dose: 26 mg/kg/day up to 1800 mg/day

VII. Adverse Effects

  1. See NSAID

VIII. Safety

  1. See NSAID
  2. Avoid in Lactation
  3. Avoid NSAIDs in pregnancy outside the first part of the second trimester (13 to 20 weeks)
    1. Teratogenic in first trimester
    2. Risk of premature ductus arteriosus closure in the fetus in third trimester
    3. Most NSAIDs carry a legacy system Pregnancy Category B or C designation (aside from third trimester)
      1. However, many obstetricians avoid NSAIDs entirely in pregnancy (even in second trimester)

IX. Resources

  1. Oxaprozin (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ea1de47e-3101-4414-817c-0a098af8988c

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Related Studies

Cost: Medications

oxaprozin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
OXAPROZIN 600 MG CAPLET Generic $0.64 each
OXAPROZIN 600 MG TABLET Generic $0.64 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Ontology: oxaprozin (C0069739)

Definition (NCI) A nonsteroidal anti-inflammatory drug (NSAID) derivative of oxazole-propionic acid with analgesic and antipyretic properties. As a first generation NSAID inhibitor, oxaprozin binds to and inactivates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory prostaglandins. When inhibiting COX-2, this agent may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. (NCI04)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C008729
SnomedCT 108518005, 386031002
English 4,5-diphenyl-2-oxazolepropionic acid, oxaprozin, 4,5-Diphenyl-2-oxazolepropionic Acid, oxaprozin (medication), OXAPROZIN, oxaprozin [Chemical/Ingredient], Oxaprozin, Oxaprozin (product), Oxaprozin (substance)
Spanish oxaprozina (producto), oxaprozina (sustancia), oxaprozina
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Analgesic Medications

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