II. Indications
- Strong oral Opioid Analgesic for moderate to severe pain
III. Precautions
- Risk of serious respiratory depression
- Among the most abused and diverted prescription medications
- Oxycodone more easily crosses blood brain barrier (lipophilic) and potentiates euphoria
IV. Preparations: Immediate Release
- Oxycodone immediate release
- Adults (and over age 12 years) 5-10 mg every 4-6 hours as needed
- Child
- Moderate dose: 0.05 to 0.15 mg/kg/dose (up to 5 mg/dose) every 4-6 hours as needed
- High dose: 0.15 to 0.3 mg/kg/dose (up to 10 mg/dose) every 4-6 hours as needed
- Tabs: 5 mg (scored), 15, 30 mg
- Solution: 5 mg/ml
- Concentrate 20 mg/ml (dissolves sublingually)
-
Acetaminophen and Oxycodone
- Percocet (Oxycodone 5 mg with Acetaminophen 325 mg)
- Dose: 1-2 orally every 6 hours as needed (adults or age over 12 years)
- Roxicet Solution (Oxycodone 5 mg and Acetaminophen 325 mg per 5 ml)
- Dose: Base on Oxycodone dose of 0.05 to 0.15 mg/kg/dose every 4-6 hours up to 5 mg/dose
- Percocet (Oxycodone 5 mg with Acetaminophen 325 mg)
V. Preparations: Controlled-Release (Extended Release)
- Oxycontin 10 mg every 12 hours
- Available in 10 mg, 15 mg, 20 mg, 30 mg, 40, 60 mg, 80 mg sustained release formulations
- Generic in U.S. as of 2016
- Precautions
- Start with short acting Oxycodone and convert to long acting based on pattern of requirements
- Titrate slowly: 80 mg is very high dose and only for Opioid tolerant patients
- Do not break or chew sustained release product (risk of Overdose)
- Sustained release product is intended only for scheduled use (not prn)
- Oxycontin true duration of action approaches 6 hours (instead of 12 hours) in many patients
- Oxycontin may offer no duration benefit over other formulations
- Oxycontin was released as MS Contin (8 hour duration) patent was expiring
- The exaggerated duration may add to misuse and abuse of Opioids
- Art Van Zee (2009) Am J Public Health 99(2): 221–7 +PMID:18799767 [PubMed]
VI. Adverse Effects
- Respiratory depression or arrest
- Reversal: Naloxone
- Nausea or Vomiting
- Constipation
- Sedation
VII. Resources
- Oxycodone Tablet (DailyMed)
- Oxycontin (DailyMed)
- Oxycodone and Acetaminophen (DailyMed)
VIII. References
- Hamilton (2012) Tarascon Pharmacopeia, Jones and Bartlett, Burlington
- Robertson (2005) Harriet Lane Handbook, Mosby, Philadelphia p. 911
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Related Studies
| oxycodone (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| OXYCODONE HCL (IR) 10 MG TAB | Generic | $0.11 each |
| OXYCODONE HCL (IR) 15 MG TAB | Generic | $0.13 each |
| OXYCODONE HCL (IR) 20 MG TAB | Generic | $0.18 each |
| OXYCODONE HCL (IR) 30 MG TAB | Generic | $0.27 each |
| OXYCODONE HCL (IR) 5 MG CAP | Generic | $0.38 each |
| OXYCODONE HCL (IR) 5 MG TABLET | Generic | $0.07 each |
| OXYCODONE HCL 100 MG/5 ML CONC | Generic | $1.97 per ml |
| OXYCODONE HCL 5 MG/5 ML SOLN | Generic | $0.06 per ml |
| OXYCODONE-ACETAMINOPHEN 10-325 MG TAB | Generic | $0.18 each |
| OXYCODONE-ACETAMINOPHEN 10-325 MG TABLET | Generic | $0.18 each |
| OXYCODONE-ACETAMINOPHEN 2.5-325 MG TABLET | Generic | $0.96 each |
| OXYCODONE-ACETAMINOPHEN 5-325 MG TAB | Generic | $0.10 each |
| OXYCODONE-ACETAMINOPHEN 5-325 MG TABLET | Generic | $0.10 each |
| OXYCODONE-ACETAMINOPHEN 7.5-325 MG TABLET | Generic | $0.14 each |
| percocet (on 1/1/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| PERCOCET 10-325 MG TABLET | Generic | $0.18 each |
| PERCOCET 5-325 MG TABLET | Generic | $0.10 each |
| PERCOCET 7.5-325 MG TABLET | Generic | $0.14 each |
| oxycontin (on 1/1/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| OXYCONTIN ER 10 MG TABLET | $4.48 each | |
| OXYCONTIN ER 15 MG TABLET | $6.57 each | |
| OXYCONTIN ER 20 MG TABLET | $8.34 each | |
| OXYCONTIN ER 30 MG TABLET | $11.61 each | |
| OXYCONTIN ER 40 MG TABLET | $14.29 each | |
| OXYCONTIN ER 60 MG TABLET | $20.27 each | |
| OXYCONTIN ER 80 MG TABLET | $24.87 each | |
| endocet (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ENDOCET 10-325 MG TABLET | Generic | $0.18 each |
| ENDOCET 5-325 MG TABLET | Generic | $0.10 each |
| ENDOCET 7.5-325 MG TABLET | Generic | $0.14 each |