II. Indications
- Strong oral Opioid Analgesic for moderate to severe pain
III. Precautions
- Risk of serious respiratory depression
- Among the most abused and diverted prescription medications
IV. Preparations: Immediate Release
- Oxycodone immediate release
- Adults (and over age 12 years) 5-10 mg every 4-6 hours as needed
- Child
- Moderate dose: 0.05 to 0.15 mg/kg/dose (up to 5 mg/dose) every 4-6 hours as needed
- High dose: 0.15 to 0.3 mg/kg/dose (up to 10 mg/dose) every 4-6 hours as needed
- Tabs: 5 mg (scored), 15, 30 mg
- Solution: 5 mg/ml
- Concentrate 20 mg/ml (dissolves sublingually)
-
Acetaminophen and Oxycodone
- Percocet (Oxycodone 5 mg with Acetaminophen 325 mg)
- Dose: 1-2 orally every 6 hours as needed (adults or age over 12 years)
- Roxicet Solution (Oxycodone 5 mg and Acetaminophen 325 mg per 5 ml)
- Dose: Base on Oxycodone dose of 0.05 to 0.15 mg/kg/dose every 4-6 hours up to 5 mg/dose
- Percocet (Oxycodone 5 mg with Acetaminophen 325 mg)
V. Preparations: Controlled-Release (Extended Release)
- Oxycontin 10 mg every 12 hours
- Available in 10 mg, 15 mg, 20 mg, 30 mg, 40, 60 mg, 80 mg sustained release formulations
- Generic in U.S. as of 2016
- Precautions
- Start with short acting Oxycodone and convert to long acting based on pattern of requirements
- Titrate slowly: 80 mg is very high dose and only for Opioid tolerant patients
- Do not break or chew sustained release product (risk of Overdose)
- Sustained release product is intended only for scheduled use (not prn)
- Oxycontin true duration of action approaches 6 hours (instead of 12 hours) in many patients
- Oxycontin may offer no duration benefit over other formulations
- Oxycontin was released as MS Contin (8 hour duration) patent was expiring
- The exaggerated duration may add to misuse and abuse of Opioids
- Art Van Zee (2009) Am J Public Health 99(2): 221–7 +PMID:18799767 [PubMed]
VI. Adverse Effects
- Respiratory depression or arrest
- Reversal: Naloxone
- Nausea or Vomiting
- Constipation
- Sedation
VII. References
- Hamilton (2012) Tarascon Pharmacopeia, Jones and Bartlett, Burlington
- Robertson (2005) Harriet Lane Handbook, Mosby, Philadelphia p. 911
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| oxycodone (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| OXYCODONE HCL 10 MG TABLET | Generic | $0.18 each |
| OXYCODONE HCL 100 MG/5 ML SOLN | Generic | $4.63 per ml |
| OXYCODONE HCL 15 MG TABLET | Generic | $0.18 each |
| OXYCODONE HCL 20 MG TABLET | Generic | $0.31 each |
| OXYCODONE HCL 30 MG TABLET | Generic | $0.32 each |
| OXYCODONE HCL 5 MG CAPSULE | Generic | $0.94 each |
| OXYCODONE HCL 5 MG TABLET | Generic | $0.10 each |
| OXYCODONE HCL 5 MG/5 ML SOLN | Generic | $0.16 per ml |
| OXYCODONE HCL ER 10 MG TABLET | Generic | $2.08 each |
| OXYCODONE HCL ER 15 MG TABLET | Generic | $3.54 each |
| OXYCODONE HCL ER 20 MG TABLET | Generic | $3.67 each |
| OXYCODONE HCL ER 30 MG TABLET | Generic | $6.12 each |
| OXYCODONE HCL ER 40 MG TABLET | Generic | $5.87 each |
| OXYCODONE HCL ER 60 MG TABLET | Generic | $9.30 each |
| OXYCODONE HCL ER 80 MG TABLET | Generic | $10.05 each |
| OXYCODONE-ACETAMINOPHEN 10-325 MG TAB | Generic | $0.46 each |
| OXYCODONE-ACETAMINOPHEN 10-325 MG TABLET | Generic | $0.46 each |
| OXYCODONE-ACETAMINOPHEN 2.5-325 MG TAB | Generic | $1.34 each |
| OXYCODONE-ACETAMINOPHEN 5-325 MG TAB | Generic | $0.13 each |
| OXYCODONE-ACETAMINOPHEN 5-325 MG TABLET | Generic | $0.13 each |
| OXYCODONE-ACETAMINOPHEN 7.5-325 MG TAB | Generic | $0.40 each |
| OXYCODONE-ACETAMINOPHEN 7.5-325 MG TABLET | Generic | $0.40 each |
| OXYCODONE-ASPIRIN 4.8355-325 MG TABLET | Generic | $0.62 each |
| percocet (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| PERCOCET 10-325 MG TABLET | Generic | $0.46 each |
| PERCOCET 5-325 MG TABLET | Generic | $0.13 each |
| PERCOCET 7.5-325 MG TABLET | Generic | $0.40 each |
| roxicodone (on 4/19/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ROXICODONE 30 MG TABLET | Generic | $0.32 each |
| oxycontin (on 2/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| OXYCONTIN 10 MG TABLET | Generic | $2.08 each |
| OXYCONTIN 15 MG TABLET | Generic | $3.54 each |
| OXYCONTIN 20 MG TABLET | Generic | $3.67 each |
| OXYCONTIN 30 MG TABLET | Generic | $6.12 each |
| OXYCONTIN 40 MG TABLET | Generic | $5.87 each |
| OXYCONTIN 60 MG TABLET | Generic | $9.30 each |
| OXYCONTIN 80 MG TABLET | Generic | $10.05 each |
| endocet (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ENDOCET 10-325 MG TABLET | Generic | $0.46 each |
| ENDOCET 2.5-325 MG TABLET | Generic | $1.34 each |
| ENDOCET 5-325 TABLET | Generic | $0.13 each |
| ENDOCET 7.5-325 MG TABLET | Generic | $0.40 each |
