II. Preparations: Non-Opioid Analgesics

  1. Acetaminophen
  2. Nonsteroidal Anti-inflammatory (NSAID)
    1. See NSAID Gastrointestinal Adverse Effects
    2. See NSAID Renal Adverse Effects
    3. COX2 Selective NSAID (e.g. Celecoxib)
    4. Acetic Acid NSAID
      1. Partial cox2-selective (e.g. Etodolac, Nabumetone)
      2. Indoles (e.g. Indomethacin, Sulindac)
      3. Pyrrolo-pyrroles - Parenteral NSAIDs (e.g. Ketorolac)
    5. Fenamate NSAID
      1. Anthranilic Acid (e.g. Meclofenamate)
      2. Acetic Acid (e.g. Diclofenac)
    6. Oxicam NSAID (e.g. Meloxicam, Piroxicam)
    7. Propionic Acid NSAID (e.g. Ibuprofen, Naproxen )
    8. Salicylates (e.g. Aspirin)
  3. Topical Analgesic
    1. Topical NSAID (diclofenac)
    2. Lidocaine Patch (Lidoderm)
    3. Capsaicin
  4. Corticosteroid
    1. High potency, high antiinflammatory and long acting agents
      1. Betamethasone
      2. Dexamethasone
    2. Moderate potency, moderate antiinflammatory and medium duration agents
      1. Methylprednisolone
      2. Triamcinolone
      3. Prednisolone
      4. Prednisone
    3. Low potency, low antiinflammatory and short duration agents
      1. Hydrocortisone
      2. Cortisone

III. Preparations: Opioid Analgesics

  1. See Opioid Prescribing Quantity
  2. See Opioid Prescription in Acute Pain
  3. See Opioid Adverse Effect Management
  4. See Narcotic Overdose
  5. Precautions
    1. See Emergency Department Pain Management
    2. See Acute Pain Stepped Oral Analgesics
    3. Non-Opioids are preferred for acute pain
    4. When Opioids are used for acute pain, limit to 3 days in most patients, and <7 days in almost all patients
    5. Avoid Chronic Opioids in non-Cancer Pain
  6. Opioids
    1. Weak Opioids
      1. Codeine (avoid)
      2. Hydrocodone (or in combinations, Vicodin, Lorcet, Vicoprofen)
      3. Tramadol (Ultram)
    2. Strong Opioids (WHO Step 3)
      1. Oxycodone (or in combination, Percocet)
      2. Hydromorphone (Dilaudid)
      3. Morphine Sulfate (MSIR, MS Contin)
      4. Fentanyl
      5. Methadone (Dolophine)
  7. Opioid Agonist-Antagonist
    1. Buprenorphine
    2. Butorphanol (Stadol)
    3. Nalbuphine (Nubain)
    4. Pentazocine (Talwin)
  8. Opioid Antagonist
    1. Naloxone
    2. Naltrexone
    3. Gastrointestinal Opioid Antagonist (e.g. Movantik, Methylnaltrexone, Symproic, Alvimopan)

V. Protocol: Approach to acute pain in adults

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Ontology: Analgesics (C0002771)

Definition (MSHCZE) Sloučeniny umožňující zmírnění bolesti bez ztráty VĚDOMÍ.
Definition (MEDLINEPLUS)

Pain relievers are medicines that reduce or relieve headaches, sore muscles, arthritis or any number of other aches and pains. There are many different pain medicines, and each one has advantages and risks. Some types of pain respond better to certain medicines than others. Each person may also have a slightly different response to a pain reliever.

Over-the-counter (OTC) medicines are good for many types of pain. There are two main types of OTC pain medications: acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs). Aspirin, naproxen (Aleve) and ibuprofen (Advil, Motrin) are examples of OTC NSAIDs. If OTC medicines don't relieve your pain, your doctor may prescribe something stronger. Many NSAIDs are available at prescription doses. The most powerful pain relievers are narcotics. They are very effective, but they can sometimes have serious side effects. Because of the risks, you must use them only under a doctor's supervision.

There are many things you can do to help ease pain. Pain relievers are just one part of a pain treatment plan.

Definition (NCI) Natural or synthetic compound mixtures, Analgesic Preparations relieve pain by altering the perception of nociceptive stimuli without loss of consciousness. Analgesic compounds may act at opioid receptors (morphine-like drugs) or at other central or peripheral sites (non-steroidal anti-inflammatory agents). (NCI04)
Definition (NCI_NCI-GLOSS) Drugs that reduce pain. These drugs include aspirin, acetaminophen, and ibuprofen.
Definition (NCI) Compounds that alleviate pain without loss of consciousness. Analgesics act by various mechanisms including binding with opioid receptors and decreasing inflammation. Choice of analgesic may be determined by the type of pain. These compounds include opioid, non-opioid and adjuvant analgesic agents.
Definition (CSP) compounds capable of relieving pain without the loss of consciousness or without producing anesthesia.
Definition (MSH) Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
Concepts Pharmacologic Substance (T121)
MSH D000700
SnomedCT 363559009, 255630003, 373265006, 53009005
LNC LP31483-8, LP134119-9, MTHU015955
English Analgesics, Anodynes, Agents, Analgesic, Analgesic Agents, Analgesic Drugs, Drugs, Analgesic, analgesics (pain medication), analgesics (medication), pain medication, analgesics, [CN100] ANALGESICS, anodyne, pain killer drug, analgesic agents, analgesic drug, analgesic drugs, analgesics drug, analgesics drugs, anodynes, pain relieving drugs, Pain-relief Medication, Pain medicine, Pain medicines, Painkillers, Pain Relievers, ANALGESICS, Analgesic product (substance), Analgesic product, analgesic, Analgesic, Analgesic (product), Analgesic (substance), miscellaneous analgesic, Analgesic, NOS, Pain Relieving Drugs, Analgesic Preparation, Analgesic Agent
French Médicaments antidouleur, Médicaments anti-douleur, Analgésiques, Agents analgésiques, Agents antalgiques, Antalgiques, Médicaments analgésiques, Médicaments antalgiques
Swedish Smärtstillande medel
Czech analgetika, anodyna
Finnish Kipulääkkeet
Italian Agenti analgesici, Farmaci analgesici, Medicamenti anodini, Antidoloriferi, Analgesici
Polish Leki przeciwbólowe, Analgetyki
Japanese 鎮痛剤, 抗痛覚物質, 鎮痛薬
Norwegian Not Translated[Analgesics]
Spanish producto analgésico (sustancia), producto analgésico, Analgésico, analgésico (producto), analgésico (sustancia), analgésico, Anodinos, Analgésicos
Portuguese Analgésico, Analgésicos, Anódinos
German Analgetika, Anodyna, Schmerzlinderungsmittel, Schmerzmittel