II. Pathophysiology
- Used to reduce severe spasticity (e.g. Spinal Cord Injury, Cerebral Palsy, Multiple Sclerosis)
III. Indications: Spasticity
IV. Contraindications
- Not indicated for general musculoskeletal problems
V. Dosing
- Start 2 to 4 mg every 8 to 12 hours as needed
- May increase to 4 to 8 mg orally every 8 hours as needed
- Maximum 24 mg/day (some references list 36 mg/day)
VI. Adverse Effects
- Sedation (24 to 50% of patients)
- Severe Hepatotoxicity
-
Blood Pressure changes
- Hypotension in 7 to 12% of patients
- Clonidine effect (risk of Hypotension and rebound Hypertension)
- Taper off over 1-2 weeks (risk of Clonidine-like rebound Hypertension effect)
VII. Metabolism
VIII. Resources
- Tizanidine Tablet (DailyMed)
IX. References
- (2019) Presc Lett 26(3):15
- LoVecchio (2023) Crit Dec Emerg Med 37(6): 32
- Wallace (1994) Neurology 44(11): S60-8 [PubMed]
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Related Studies
| tizanidine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| TIZANIDINE HCL 2 MG CAPSULE | Generic | $0.09 each |
| TIZANIDINE HCL 2 MG TABLET | Generic | $0.06 each |
| TIZANIDINE HCL 4 MG CAPSULE | Generic | $0.15 each |
| TIZANIDINE HCL 4 MG TABLET | Generic | $0.05 each |
| TIZANIDINE HCL 6 MG CAPSULE | Generic | $0.20 each |