Calcitonin

Aka: Calcitonin, Thyrocalcitonin

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II. Physiology

  1. Peptide Hormone, secreted by parafollicular cells of the Thyroid Gland
    1. Secreted in response to Hypercalcemia
  2. Lowers Serum Calcium levels (esp. in children)
    1. Decreases Osteoclast formation and bone resorptive activity (bone breakdown)
    2. Increases renal Calcium excretion
    3. Weakly opposes Parathyroid Hormone

III. Indications: Osteoporosis

  1. Weak Osteoporosis Management alternative for women not on Estrogen Replacement
  2. Painful Vertebral osteoporotic Fracture

IV. Efficacy

  1. Not as effective as Estrogen Replacement
  2. Reduces Vertebral Fractures 30-60% for >2 years
  3. Increases BMD of spine 3% in osteoporotic women

V. Preparations

  1. Calcitonin-Salmon
    1. Dosing: 100 IU SQ/IM daily ($195/mo)
  2. Miacalcin
    1. Dosing: 200 IU (1 spray) intranasally daily in alternating nares ($50/mo)

VI. Precautions

  1. Anaphylaxis risk (use test dose in clinic)
  2. Possible increased risk of cancer

VII. Adverse Effects

  1. Skin Flushing
  2. Skin rash
  3. Nausea
  4. Dizzy

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Related Studies

Cost: Medications

calcitonin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
CALCITONIN-SALMON 200 UNITS SP Generic $11.03 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Ontology: Calcitonin (C0006668)

Definition (MSH) A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.
Definition (CSP) a peptide hormone secreted by the parafollicular cells of the thyroid gland in response to hypercalcemia, which lowers blood calcium and phosphate by promoting renal excretion; chemotherapy for Paget's disease and severe hypercalcemia.
Concepts Pharmacologic Substance (T121) , Hormone (T125) , Amino Acid, Peptide, or Protein (T116)
MSH D002116
SnomedCT 373474005, 63730009
LNC LP14649-5, MTHU003443
English Calcitonin, Calcitonin(1-32), Calcitrin, Thyrocalcitonin, calcitonin, thyrocalcitonin, Calcitonin [Chemical/Ingredient], calcitonins, Calcitonin agent, Calcitonin agent (substance), CT - Calcitonin, Calcitonin (substance), CALCITONIN
Portuguese Tireocalcitonina, Tirocalcitonina, Calcitonina
Swedish Kalcitonin
Czech kalcitonin
Finnish Kalsitoniini
French TCT (Thyrocalcitonin), Calcitonine, Thyrocalcitonine
Italian Tirocalcitonina, Calcitrin, Calcitonina
Russian TIREOKAL'TSITONIN, KAL'TSITONIN, КАЛЬЦИТОНИН, ТИРЕОКАЛЬЦИТОНИН
Japanese カルシトニン, チロカルシトニン, カルチトニン
Croatian KALCITONIN
Polish Tyreokalcytonina, Kalcytonina
Norwegian Kalsitonin, Calcitrin, Calcitonin(1-32), Thyreocalcitonin
Spanish agente con calcitonina, agente con calcitonina (sustancia), calcitonina (sustancia), calcitonina, tirocalcitonina, Calcitonina, Tirocalcitonina
German Calcitonin, Kalzitonin, Thyrocalcitonin
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pharmacology

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