II. Indications
- Severe Muscle spasticity (e.g. Spinal Cord Injury, Cerebral Palsy, Multiple Sclerosis)
- Alcohol Withdrawal
III. Pharmacology
- Baclofen is a Skeletal Muscle Relaxant that binds GABA B receptors
- Oral Baclofen does not cross blood brain barrier well
- Requires intolerable oral doses to offer effect
- Instead, Baclofen is typically used via Baclofen Intrathecal Pump
- Intrathecal Baclofen has fewer side effects and may be used at low dose
IV. Dosing
- Baclofen 50-100 mcg/day via Intrathecal Pump (up to 900 mcg) and slowly titrate to effect
- Small dose modifications can have significant effects on patient findings (due to direct CSF drug delivery)
- Taper off over 1-2 weeks (risk of Hallucinations, Seizures if abruptly stopped)
V. Complications
VI. References
- Riley and LoVecchio (2021) Crit Dec Emerg Med 35(5):28
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Related Studies
| baclofen (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| BACLOFEN 10 MG TABLET | Generic | $0.05 each |
| BACLOFEN 20 MG TABLET | Generic | $0.09 each |
| BACLOFEN 5 MG TABLET | Generic | $0.26 each |
| BACLOFEN 5 MG/5 ML SOLUTION | Generic | $1.06 per ml |