Depression Provoking Medications

Aka: Depression Provoking Medications, Medications Predisposing to Depression, Medication Causes of Depression, Suicidality Associated with Medications

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II. Causes: Suicidality Associated with Medications

  1. Varenicline (Chantix)
  2. Anticonvulsants
  3. Antidepressants in teens
  4. Singulair is being investigated for possible increased Suicidality
    1. (2008) Prescriber's Letter 15(5): 27-8
  5. Accutane does not appear to increase risk despite early reports
    1. Marqueling (2007) Semin Cutan Med Surg 26(4):210-20 [PubMed]

III. Causes: Recreational or Illicit Drug use

  1. Alcohol Abuse
  2. Benzodiazepine
  3. Barbiturate
  4. Narcotic or opiate Intoxication
  5. Amphetamine withdrawal
  6. Cocaine withdrawal
  7. Anabolic Steroid use
  8. Phencyclidine (PCP)
  9. Marijuana

IV. Causes: Antihypertensive medication

  1. Highest risk
    1. Beta Blockers (Propranolol)
    2. Reserpine (Depletes Catecholamines)
    3. Methyldopa (Depletes Catecholamines)
  2. Low risk
    1. Clonidine (Catapres)
    2. Thiazide Diuretics
    3. Guanethidine
    4. Prazosin
    5. Hydralazine
  3. No risk
    1. ACE Inhibitors
    2. Calcium Channel Blockers
    3. Diuretics

V. Causes: Gastrointestinal agents

  1. Metoclopramide (Reglan)
  2. Ranitidine
  3. Cimetidine

VI. Causes: Chemotherapeutic medications

  1. 6-Azauridine
  2. Asparaginase
  3. Azathioprine (Imuran)
  4. Bleomycin
  5. Cisplatin
  6. Cyclophosphamide
  7. Doxorubicin
  8. Mithramycin
  9. Vinblastine
  10. Vincristine

VII. Causes: Neurologic Agents

  1. Anti-parkinsonian Medications
    1. Amantadine
    2. Bromocriptine
    3. Levodopa
  2. Anti-Seizure Medications
    1. Carbamazepine (Tegretol)
    2. Ethosuximide (Zarontin)
    3. Phenobarbital
    4. Phenytoin (Dilantin)
    5. Primidone

VIII. Causes: Psychotropic agents

  1. Catecholamine receptor blockers
    1. Fluphenazine (Prolixin)
    2. Haloperidol (Haldol)
  2. Sedatives
    1. Barbiturates
    2. Benzodiazepines

IX. Causes: Other medications

  1. Baclofen
  2. Cycloserine
  3. Disulfiram (Antabuse)
  4. NSAIDs
  5. Sulfonamides
  6. Corticosteroids
  7. Digitalis Glycosides (Digoxin)
  8. Oral Contraceptives
  9. Isoniazid
  10. Montelukast (Singulair)

X. References

  1. Beers (1990) Drugs 40(6):792-9 [PubMed]
  2. Citrome (1994) Postgrad Med, 95(1): 137-45 [PubMed]
  3. Ferris (1995) Depression Primary Care, PGM, p.36-44
  4. Kuzel (1996) Postgrad Med, 99(5): 179-95 [PubMed]

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