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Definition (NCI_NCI-GLOSS)
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The active ingredient in a drug used together with other drugs to treat several types of cancer, including advanced Hodgkin lymphoma and advanced testicular germinal-cell cancers. It is also being studied in the treatment of other types of cancer. Vinblastine comes from the periwinkle plant Vinca rosea Linn. It blocks cell growth by stopping cell division and may kill cancer cells. It is a type of vinca alkaloid and a type of antimitotic agent.
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Definition (NCI)
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A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)
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Definition (MSH)
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Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
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Definition (CSP)
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promotes paracrystalline aggregates of tubulin and thus inhibits microtubule formation; used as a cytologic probe for microtubule function, and clinically as an antineoplastic.
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Definition (PDQ)
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A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42951&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42951&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C930" NCI Thesaurus)
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| Concepts |
Pharmacologic Substance
(T121)
, Biologically Active Substance
(T123)
, Organic Chemical
(T109)
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| MSH |
D014747
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| SnomedCT |
12436009, 387051009, 20303001, 387115000 |
| English |
Vinblastine, Vincaleukoblastine, vincaleukoblastine, Vincaleucoblastine, VBL, VinBLAStine, Vinblastine [Chemical/Ingredient], vinBLAStine, vinblastine, VINCALEUKOBLASTINE, VINBLASTINE, VLB, Vinblastine (product), Vinblastine (substance) |
| Swedish |
Vinblastin
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| Czech |
vinblastin
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| Finnish |
Vinblastiini
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| Russian |
VINBLASTIN, VINKALEIKOBLASTIN, ВИНБЛАСТИН, ВИНКАЛЕЙКОБЛАСТИН |
| Japanese |
ビンブラスチン, 硫酸ビンブラスチン, エクザール, ビンカロイコブラスチン |
| Croatian |
VINBLASTIN
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| Polish |
Winblastyna, Winkaleukoblastyna |
| Spanish |
vinblastina (producto), vinblastina (sustancia), vinblastina, Vinblastina, Vincaleucoblastina |
| French |
Vinblastine
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| German |
Vinblastin, Vincaleukoblastin |
| Italian |
Vinblastina
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| Portuguese |
Vimblastina, Vincaleucoblastina |
