Glycoprotein IIB/IIIA Inhibitor

Aka: Glycoprotein IIB/IIIA Inhibitor, GP IIB/IIA Inhibitor, Abciximab, ReoPro, Tirofiban, Aggrastat, Eptifibatide, Integrilin

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II. Indications

  1. Non-Q-Wave Myocardial Infarction
  2. High risk Unstable Angina
  3. Angioplasty

III. Mechanism

  1. Inhibits Platelet aggregation

IV. Dosing: Abciximab (ReoPro)

  1. Load: 0.25 mg/kg IV bolus
  2. Infuse: 0.125 ug/kg/min up to 10 ug/min IV x12 hours

V. Dosing: Eptifibatide (Integrilin)

  1. Acute Coronary Syndrome
    1. Load: 180 ug/kg
    2. Infuse: 2 ug/kg/min IV x72 hours
  2. Angioplasty
    1. Load: 135 ug/kg IV before procedure
    2. Infuse: 0.5 ug/kg/min IV x24 hours

VI. Dosing: Tirofiban (Aggrastat)

  1. Load: 0.4 ug/kg/min for 30 minutes
  2. Infuse: 0.1 ug/kg/min
  3. Infusion duration
    1. Acute Coronary Syndrome: 48 to 108 hours
    2. Angioplasty: 12 to 24 hours

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