II. Indications
- Non-Q-Wave Myocardial Infarction
- High risk Unstable Angina
- Angioplasty
III. Mechanism
- Inhibits Platelet aggregation
IV. Dosing: Abciximab (ReoPro)
- Load: 0.25 mg/kg IV bolus
- Infuse: 0.125 ug/kg/min up to 10 ug/min IV x12 hours
V. Dosing: Eptifibatide (Integrilin)
-
Acute Coronary Syndrome
- Load: 180 ug/kg
- Infuse: 2 ug/kg/min IV x72 hours
-
Angioplasty
- Load: 135 ug/kg IV before procedure
- Infuse: 0.5 ug/kg/min IV x24 hours
VI. Dosing: Tirofiban (Aggrastat)
- Load: 0.4 ug/kg/min for 30 minutes
- Infuse: 0.1 ug/kg/min
- Infusion duration
- Acute Coronary Syndrome: 48 to 108 hours
- Angioplasty: 12 to 24 hours