Definition (NCI)
|
A methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased levels of cyclic adenosine monophosphate (cAMP) in erythrocytes, endothelium, and the surrounding tissues. This leads to vasodilation, improves erythrocyte flexibility, and enhances blood flow. In addition, the increased level of cAMP in platelets inhibits platelet aggregation, which may contribute to a reduction in blood viscosity. This agent also inhibits production of tumor necrosis factor-alpha and interferon-gamma, while it induces Th2-like (T-helper 2) cytokine production, thereby inhibiting Th1-mediated (T-helper 1) inflammatory and autoimmune responses.
|
Definition (NCI_NCI-GLOSS)
|
A drug used to prevent blood clotting and as a treatment that may help decrease weight loss in people with cancer.
|
Definition (CSP)
|
metabolite of pentifylline (a preparation of theobromine and hexyl halide); used as a vasodilator.
|
Definition (MSH)
|
A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.
|
Definition (PDQ)
|
A methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased levels of cyclic adenosine monophosphate (cAMP) in erythrocytes, endothelium, and the surrounding tissues. This leads to vasodilation, improves erythrocyte flexibility, and enhances blood flow. In addition, the increased level of cAMP in platelets inhibits platelet aggregation, which may contribute to a reduction in blood viscosity. This agent also inhibits production of tumor necrosis factor-alpha and interferon-gamma, while it induces Th2-like (T-helper 2) cytokine production, thereby inhibiting Th1-mediated (T-helper 1) inflammatory and autoimmune responses. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41432&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41432&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C733" NCI Thesaurus)
|
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D010431
|
SnomedCT |
91376007, 387522004 |
LNC |
LP14918-4, MTHU035938, MTHU002178 |
English |
Oxpentifylline, 1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-, 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione, pentoxifylline, PTX, Dentoxifylline, pentoxifylline (medication), PENTOXIFYLLINE, Pentoxifylline ER, Pentoxifylline [Chemical/Ingredient], pentoxyphylline, Pentoxyfylline, Pentoxyphylline, Pentoxifylline (product), Pentoxifylline (substance), oxpentifylline, Pentoxifylline |
Swedish |
Pentoxifyllin
|
Czech |
pentoxifylin
|
Finnish |
Pentoksifylliini
|
Russian |
TRENTAL, PENTOKSIFILLIN, ПЕНТОКСИФИЛЛИН, ТРЕНТАЛ |
Italian |
Oxpentifillina, Pentossifillina |
Croatian |
PENTOKSIFILIN
|
Polish |
Pentoksyfilina
|
Japanese |
ペントキシフィリン, オクスペンチフィリン |
Spanish |
oxpentifilina, pentoxifilina (producto), pentoxifilina (sustancia), pentoxifilina, Pentoxifilina |
French |
Pentoxifylline
|
German |
Pentoxifyllin
|
Portuguese |
Pentoxifilina
|