II. Background

  1. Pregnancy Categories will be replaced on medication bottles with specific warnings and precautions by 2020 in U.S.
    1. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm425317.htm
    2. Although FDA Pregnancy Categories are no longer FDA designated, they are included here
      1. As of 2018, succinct guidance (to replace ABCDX) on specific drugs in pregnancy is lacking

III. Class B: No risk in controlled animal studies

IV. Class C: Small risk in controlled animal studies

  1. Antiplatelet Medications
    1. Clopidogrel (Plavix) - not in Briggs (1998)
    2. Dipyridamole (Persantine)
    3. Ticlopidine (Ticlid) - not in Briggs (1998)
  2. Chemotherapeutics
    1. Asparaginase
    2. Dacarbazine
    3. Dactinomycin
    4. Interferon alfa

V. Class D: Strong evidence of risk to the human fetus

VI. Class X: Very high risk to the human fetus

  1. Leuprolide (Lupron)
  2. Aminopterin

VII. References

  1. Briggs (1998) Drugs in Pregnancy and Lactation, 5th ed
  2. Larimore (2000) Prim Care 27(1):35-53 [PubMed]

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