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Definition (NCI)
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A semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum. Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. (NCI04)
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Definition (NCI_NCI-GLOSS)
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A drug used to treat testicular and small cell lung cancers. It is also being studied in the treatment of several other types of cancer. Vepesid blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of podophyllotoxin derivative and a type of topoisomerase inhibitor.
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Definition (MSH)
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A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
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Definition (CSP)
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glucopyranosyl substituted naphthalene derived from podophyllin; mutagen and immunosuppressant used in combination antineoplastic therapy for several human malignancies.
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Definition (PDQ)
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A semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum. Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39207&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39207&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C491" NCI Thesaurus)
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| Concepts |
Pharmacologic Substance
(T121)
, Carbohydrate
(T118)
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| MSH |
D005047
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| SnomedCT |
387316009, 56928005 |
| English |
Demethyl Epipodophyllotoxin Ethylidine Glucoside, Eposide, Etoposide, Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 9-((4,6-O-ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-, etoposide, 9-[(4,6-O-Ethylidene-beta-D-glucopyranosyl]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 4'-Demethylepipodophyllotoxin 9-[4,6-O-ethylidene-beta-D-glucopyranoside, etoposide (medication), ETOPOSIDE, Etoposide [Chemical/Ingredient], eposide, 4'-Demethylepipodophyllotoxin 9-[4,6-O-ethylidene-beta-D-glucopyranoside], 9-[(4,6-O-Ethylidene-beta-D-glucopyranosyl]oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, EPEG, EPEG - Etoposide, Etoposide product, Etoposide (product), Etoposide (substance) |
| Swedish |
Etoposid
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| Czech |
etoposid
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| Finnish |
Etoposidi
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| Italian |
Demetil epipodofillotossina etilidene glucoside, Eposide, Etoposide |
| Russian |
ETOPOZID, DIMETILEPIPODOFILLOTOKSINA ETILIDIN, VP 16-213, ДИМЕТИЛЭПИПОДОФИЛЛОТОКСИНА ЭТИЛИДИН, ЭТОПОЗИД |
| Japanese |
エトポシド, デメチルエピポドフィロトキシンエチリジングルコシド |
| Polish |
Etopozyd
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| Spanish |
etopósido (producto), etopósido (sustancia), etopósido, Etopósido, Glucósido de Dimetil Epipodofilotoxina Etilidina |
| French |
Étoposide
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| German |
Demethylepipodophyllotoxin-Ethylidinglucosid, Etoposid |
| Portuguese |
Desmetilepipodofilotoxina Etilidina Glucosídeo, Etoposídeo |
