II. Indications
III. Mechanism
- Antimetabolite, Antineoplastic Agent
- Romidepsin is a bicyclic depsipeptide Antibiotic extracted from the bacterium Chromobacterium violaceum
- Romidepsin, once activated intracellularly, is a Histone Deacetylase Inhibitor (HDAC Inhibitor)
- Histones are the spools around which DNA are wrapped, and which play a role in gene expression
- Cancers may be facilitated by abnormally expressed genes in specific histone regions
- HDAC Inhibitors block histone deacetylase
- Histone deacetylase is an enzyme that catalyzes removal of acetyl groups from core histones
- Results in hyperacetylation of histones, suppressing gene expression and cell differentiation
- Histones are the spools around which DNA are wrapped, and which play a role in gene expression
- Romidepsin other effects
- Inhibits Hypoxia-induced Angiogenesis
- Decreases heat shock Protein 90 (Hsp90)-dependent oncoproteins
IV. Medications
- Romidepsin powder for IV solution
V. Dosing
- See other references for disease specific dosing protocols
- Adults: 14 mg/m2 IV on days 1, 8 and 15 of 28 day cycles
VI. Adverse Effects
VII. Safety
- Avoid in Pregnancy (any trimester)
- Use reliable Contraception
- Avoid in Lactation
- Monitoring
VIII. Drug Interactions
- Strong CYP3A4 Inhibitors and Inducers
- Avoid in combination with Romidepsin