II. Preparations: Traditional Chemotherapy
- Alkylating Agent
- Antimetabolite Chemotherapy
- Hormonally Active Chemotherapy
- Plant Alkaloid Chemotherapy
- Antibiotic Chemotherapy
- Miscellaneous Medication
- Amsacrine
- Asparaginase
- Hydoxyurea
- Mitoxantrone
- Mitotane (Lysodren)
- Quinacrine
III. Preparations: Targeted Cancer Therapy
IV. Management: General
- See Cancer Symptom
-
Exercise encouraged following high dose Chemotherapy
- Safe
- Prevents deconditioning
- Decreases toxic side effects of Chemotherapy
- Dimeo (1997) Blood 90:3390-4 [PubMed]
V. Management: Extravasation of agents from IV
- Practice vigilent prevention
- Findings: Onset with hours of Chemotherapy
- Early: Pain, local erythema and swelling
- Later: Blanching, Blistering, discoloration and tissue necrosis
- Management: Early recognition and treatment is critical
- Immediately stop any infusion
- Leave cannula in place until management plan is established
- Apply ice to area
- Do not compress area
- Use antidotes if available
- Urgent Consultations with Oncology and Surgery
- Debridement with skin grafting may be needed
- Complications
- Scarring
- Contractures
- Amputation
- References