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Definition (NCI)
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A synthetic form of the endogenous androgenic steroid testosterone. In vivo, testosterone is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription factor complexes, stimulating the expression of various responsive genes. DHT binds with higher affinity to androgen receptors than testosterone, activating gene expression more efficiently. In addition, testosterone is irreversibly converted to estradiol by the enzyme complex aromatase, particularly in the liver and adipose tissue. Testosterone and DHT promote the development and maintenance of male sex characteristics related to the internal and external genitalia, skeletal muscle, and hair follicles; estradiol promotes epiphyseal maturation and bone mineralization. Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative.
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Definition (NCI_NCI-GLOSS)
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A hormone made mainly in the testes (part of the male reproductive system). It is needed to develop and maintain male sex characteristics, such as facial hair, deep voice, and muscle growth. Testosterone may also be made in the laboratory and is used to treat certain medical conditions.
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Definition (CSP)
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major androgenic hormone produced by the Leydig cells of the testes.
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Definition (MSH)
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A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
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Definition (PDQ)
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A synthetic form of the endogenous androgenic steroid testosterone. Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative. This agent and its derivatives promote the maintenance of male sex characteristics. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42926&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42926&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C862" NCI Thesaurus)
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| Concepts |
Pharmacologic Substance
(T121)
, Hormone
(T125)
, Steroid
(T110)
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| MSH |
D013739
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| SnomedCT |
109033004, 43688007 |
| LNC |
LP14045-6, MTHU002002 |
| English |
Testosterone, Delta4-Androsten-17beta-ol-3-one, Trans-Testosterone, therapeutic testosterone, testosterone, testosterones, testosterones (medication), testosterone (medication), TESTOSTERONE, Testosterone [Chemical/Ingredient], 17 beta Hydroxy 4 Androsten 3 one, 17-beta-Hydroxy-4-Androsten-3-one, Androst-4-en-17beta-ol-3-one, Testosterone product, Total testosterone, Testosterone (substance), Testosterone preparation (product), Testosterone preparation, TESTO, Testosterone preparation (substance), Delta4-androsten-17beta-ol-3-one, (17Beta)-17-hydroxyandrost-4-en-3-one, Therapeutic Testosterone |
| Swedish |
Testosteron
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| Czech |
testosteron
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| Finnish |
Testosteroni
|
| French |
17bêta-Hydroxy-androst-4-én-3-one, Testostérone |
| Italian |
17 beta-hydroxy-4-androstene-3-one, Testosterone |
| Russian |
TESTOSTERON, ТЕСТОСТЕРОН |
| Japanese |
テストステロン
|
| Spanish |
preparado con testosterona (producto), testosterona (producto), preparado con testosterona, preparado de testosterona (producto), preparado de testosterona (sustancia), preparado de testosterona, testosterona (sustancia), testosterona, Testosterona |
| Croatian |
TESTOSTERON
|
| Polish |
Testosteron
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| Norwegian |
Testosteron, 17-beta-hydroksi-4-androsten-3-on |
| German |
Testosteron
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| Portuguese |
Testosterona
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