II. Medications: Hormone Analogs

  1. Background
    1. Naturally occurring Hormones or their derivatives
  2. Corticosteroids (lymphoid malignancy)
    1. Short-acting (e.g. Hydrocortisone)
    2. Intermediate-acting (e.g. Prednisone, Methylprednisolone)
    3. Long-acting (e.g. Dexamethasone)
  3. Somatostatin Analogs (GI neuroendocrine tumors, Carcinoid Syndrome, Merkel Cell carcinoma)
    1. Octreotide (Sandostatin)
    2. Lanreotide (Somatuline)
  4. Progestins
    1. Megestrol acetate
    2. Medroxyprogesterone acetate
  5. Conjugates (novel, hormonal agents conjugated to a cytotoxic agent)
    1. Estramustine (EmCyt)
      1. Estrogen conjugated to an alkylkating agent
      2. Selective accumulation of alkylating cytotoxic effects in Estrogen receptor positive tumor cells
      3. Used in Prostate Cancer
  6. Other Uncommonly used (or historically used) hormonal Chemotherapy agents
    1. Androgens (Historical use in Breast Cancer)
      1. Fluoxymesterone
      2. Danazol
    2. Estrogens (Uncommon use in Prostate Cancer)
      1. Diethylstilbesterol

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