II. Medications: Hormone Analogs
- Background
- Naturally occurring Hormones or their derivatives
-
Corticosteroids (lymphoid malignancy)
- Short-acting (e.g. Hydrocortisone)
- Intermediate-acting (e.g. Prednisone, Methylprednisolone)
- Long-acting (e.g. Dexamethasone)
-
Somatostatin Analogs (GI neuroendocrine tumors, Carcinoid Syndrome, Merkel Cell carcinoma)
- Octreotide (Sandostatin)
- Lanreotide (Somatuline)
-
Progestins
- Megestrol acetate
- Medroxyprogesterone acetate
- Conjugates (novel, hormonal agents conjugated to a cytotoxic agent)
- Estramustine (EmCyt)
- Estrogen conjugated to an alkylkating agent
- Selective accumulation of alkylating cytotoxic effects in Estrogen receptor positive tumor cells
- Used in Prostate Cancer
- Estramustine (EmCyt)
- Other Uncommonly used (or historically used) hormonal Chemotherapy agents
- Androgens (Historical use in Breast Cancer)
- Fluoxymesterone
- Danazol
- Estrogens (Uncommon use in Prostate Cancer)
- Diethylstilbesterol
- Androgens (Historical use in Breast Cancer)
III. Medications: Hormone Synthesis Inhibitors
- Gonadotropin-Releasing Hormone Agonists (Breast Cancer, Prostate Cancer)
- Gonadotropin-Releasing Hormone Antagonists (Prostate Cancer)
- Androgen Synthesis Inhibitor (Prostate Cancer)
-
Aromatase Inhibitors (Breast Cancer)
- Letrozole (Femara, reversible)
- Anastrozole (Arimidex, reversible)
- Exemestane (Aromasin, irreversible)
- Aminoglutethimide (Cytadren)
IV. Medications: Hormone Receptor Inhibitors
- Selective Estrogen Receptor Modulators (SERMs, Breast Cancer)
- Antiandrogens - Non-Steroidal Testosterone Receptor Antagonists - First Generation (Prostate Cancer)
- Antiandrogens - Non-Steroidal Testosterone Receptor Antagonists - Second Generation (Prostate Cancer)
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Related Studies
Definition (MSH) | Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079) |
Concepts | Pharmacologic Substance (T121) |
MSH | D018931 |
English | Agents, Antineoplastic Hormonal, Antineoplastic Agents, Hormonal, Antineoplastic Drugs, Hormonal, Antineoplastic Hormonal Agents, Antineoplastic Hormonal Drugs, Antineoplastics, Hormonal, Drugs, Antineoplastic Hormonal, Hormonal Agents, Antineoplastic, Hormonal Antineoplastic Agents, Hormonal Antineoplastic Drugs, Hormonal Antineoplastics, Hormonal Drugs, Antineoplastic, HORMONAL ANTINEOPL DRUGS, ANTINEOPL HORMONAL AGENTS, HORMONAL ANTINEOPL, HORMONAL AGENTS ANTINEOPL, ANTINEOPL HORMONAL, ANTINEOPL DRUGS HORMONAL, ANTINEOPL HORMONAL DRUGS, HORMONAL ANTINEOPL AGENTS, ANTINEOPL AGENTS HORMONAL |
French | Antinéoplasique hormonal, Antinéoplasiques hormonaux |
Swedish | Cellgifter, hormonella |
Czech | antitumorózní látky hormonální |
Finnish | Hormonaaliset solunsalpaajat |
Italian | Farmaci antineoplastici ormonali, Antineoplastici ormonali |
Russian | PROTIVOOPUKHOLEVYE SREDSTVA GORMONAL'NYE, GORMONAL'NYE PROTIVOOPUKHOLEVYE SREDSTVA, ГОРМОНАЛЬНЫЕ ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА, ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА ГОРМОНАЛЬНЫЕ |
Croatian | ANTITUMORSKA SREDSTVA, HORMONALNA |
Polish | Leki przeciwnowotworowe hormonalne |
Japanese | 抗癌剤-ホルモン性, ホルモン性抗腫瘍剤, ホルモン性抗腫瘍薬, 抗腫瘍剤-ホルモン性, ホルモン性抗癌剤 |
Portuguese | Agentes Antineoplásicos Hormonais, Antineoplásicos Hormonais |
Spanish | Antineoplásicos Hormonales, Agentes Antineoplásicos Hormonales, Agentes Hormonales Antineoplásicos |
German | Antineoplastika, hormonelle, Hormonelle Antineoplastika |
Ontology: Cancer hormonal therapy (C0877050)
Concepts | Therapeutic or Preventive Procedure (T061) |
Italian | Terapia ormonale tumorale |
Japanese | ガンホルモンリョウホウ, 癌ホルモン療法 |
Czech | Hormonální léčba rmaligního nádorovéo onemocnění |
English | cancers hormonal therapy, cancer hormonal therapy, hormonal therapy cancer, Cancer hormonal therapy |
Spanish | Hormonoterapia contra el cáncer |
Hungarian | Rák hormonkezelés |
Portuguese | Terapia hormonal cancerosa |
Dutch | hormonale kankertherapie |
French | Traitement hormonal anticancéreux |
German | hormonelle Krebstherapie |