II. Definitions
- Autologous Blood Transfusion (Autotransfusion)
- Blood Product Transfusion in which the recipient is also the donor, and receives their own Blood Products
- Recipient may donate their blood in preparation for major surgery in which large blood loss is expected
- Hemothorax may also be drained, filtered and re-transfused (e.g. Hemovac or Cell Saver)
- Red Blood Cell Transfusion
- Donor erythrocytes (Red Blood Cells) are processed, filtered, tested and reinfused into a recipient
III. Preparations
- Packed Red Blood Cells are derived from whole blood by removing 250 ml plasma
- Remaining product contains 200-250 ml per unit pRBC
- Most centers filter Leukocytes before storage
- Decreases Febrile Nonhemolytic Transfusion Reaction risk
- CMV-safe
IV. Precautions
- Transfused Red Blood Cell lifespan is 50-60 days at best (significantly shorter than the 120 lifespan of a native RBC)
- Without Iron Replacement and intact RBC synthetic function, expect Hemoglobin to drop again within weeks
- Treat the underlying cause of chronic Anemia in hemodynamically stable, relatively asymptomatic patients
- Erythropoietin is preferred in Anemia due to Chronic Renal Failure, Chemotherapy
- Iron Replacement is preferred in chronic Iron Deficiency Anemia (e.g. chronic Menorrhagia)
V. Indications
- Acute Sickle Cell Crisis (CVA Prevention)
- Massive acute blood loss >1500 ml (30% of Blood Volume)
- Hemorrhagic Shock
- Hemoglobin <7.0 g/dl and no serious comorbidity (and no ongoing bleeding)
- Hemoglobin <9.0 g/dl with serious comorbidity (e.g. cardiovascular disease, active bleeding)
- Symptomatic Anemia
- Severe Fatigue, weakness, or Dizziness
- Dyspnea
- Altered Level of Consciousness
- Angina
- Congestive Heart Failure
- Hospitalized patient criteria (per American Association of Blood Banks)
- Hemoglobin <7 mg/dl if hemodynamically stable (even if critically ill)
- Hemoglobin <8 mg/dl if orthopedic surgery, cardiac surgery or preexisting Coronary Artery Disease
- Unclear threshold for Acute Coronary Syndrome, severe Thrombocytopenia, chronic transfusion-dependent Anemia
VI. Dosing
-
Massive Hemorrhage
- See Massive Hemorrhage for protocol
- Hemodynamically stable, non-bleeding patient
- Transfuse 1 unit pRBC at a time with reassessment of status between units
VII. Labs
-
Hemoglobin
- Expect one unit pRBC to raise Hemoglobin by 1 g/dl
-
Hematocrit
- Expect one unit pRBC to raise Hematocrit by 3%
VIII. Adverse Effects
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Related Studies
| Definition (NCI_NCI-GLOSS) | The infusion of components of blood or whole blood into the bloodstream. The blood may be donated from another person, or it may have been taken from the person earlier and stored until needed. |
| Definition (NCI) | The injection of whole blood or a blood component directly into the bloodstream. |
| Definition (MSH) | The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed) |
| Definition (CSP) | introduction of whole blood or blood component directly into the blood stream. |
| Concepts | Therapeutic or Preventive Procedure (T061) |
| MSH | D001803 |
| SnomedCT | 233557002, 151000002, 266806005, 180209006, 116859006 |
| CPT | 36430 |
| LNC | LP32812-7, LP34333-2, MTHU020992, LA9940-3, LA21147-6 |
| English | Blood Transfusions, Transfusions, Blood, Transfusion, Blood, Transfusion, blood transfusion (treatment), blood transfusion, Transfusion of Blood Products, blood transfusions, Transfusion of blood, Blood transfusion (& cell) (procedure), Cell -blood-transfusion, Blood transfusion (procedure), Blood transfusion (& cell), Transfusion - blood, Blood cell transfusion, blood transfusion (___ ml), Transfusions, Blood--Transfusion, transfusion, Blood Transfusion(s), Blood transfusion, BT - Blood transfusion, Transfusion (Blood), Blood Component Transfusion, Blood Transfusion, Transfusion, blood NOS |
| Dutch | bloedtransfusie, Bloedtransfusie |
| German | Vollbluttransfusion, Bluttransfusion, Blutübertragung |
| Portuguese | Transfusão de sangue, Transfusão Sanguínea, Transfusão de Sangue |
| Spanish | Transfusión sanguínea, Transfusión Sanguínea |
| Swedish | Blodtransfusion |
| Japanese | ﾕｹﾂ, 輸血 |
| Czech | krevní transfúze, Krevní transfuze, transfuze krve |
| Finnish | Verensiirto |
| Russian | TRANSFUZIIA KROVI, PERELIVANIE KROVI, GEMOTRANSFUZIIA, ГЕМОТРАНСФУЗИЯ, ПЕРЕЛИВАНИЕ КРОВИ, ТРАНСФУЗИЯ КРОВИ |
| French | Transfusion de sang, Transfusion sanguine |
| Italian | Trasfusioni di sangue, Trasfusione di sangue |
| Croatian | TRANSFUZIJA KRVI |
| Polish | Przetaczanie krwi, Transfuzja krwi |
| Hungarian | Vérátömlesztés |
| Norwegian | Blodoverføring, Blodoverføringer, Blodtransfusjon, Blodtransfusjoner |
Ontology: Blood Transfusion, Autologous (C0005842)
| Definition (NCI) | Infusion of previously obtained autologous blood or blood products back to the same individual. |
| Definition (MSH) | Reinfusion of blood or blood products derived from the patient's own circulation. (Dorland, 27th ed) |
| Definition (CSP) | reinfusion of blood or blood products derived from the patient's own circulation. |
| Definition (NIC) | Collecting and reinfusing blood that has been lost intraoperatively or postoperatively from clean wounds |
| Definition (ALT) | Collecting a client/patient's intraoperative and/or postoperative blood, taken from a clean wound(s) and/or vein, and reinfusing it into his or her body. Service is billed per treatment. |
| Concepts | Therapeutic or Preventive Procedure (T061) |
| MSH | D001804 |
| SnomedCT | 3320000 |
| English | Autologous Blood Transfusion, Autologous Blood Transfusions, Autotransfusion, Autotransfusions, Blood Transfusion, Autologous, Blood Transfusions, Autologous, Transfusion, Autologous Blood, Transfusions, Autologous Blood, autotransfusion, Autotransfusion Procedure, TRANSFUSION AUTOL BLOOD, BLOOD TRANSFUSIONS AUTOL, AUTOL BLOOD TRANSFUSIONS, TRANSFUSIONS AUTOL BLOOD, BLOOD TRANSFUSION AUTOL, AUTOL BLOOD TRANSFUSION, ABT - Autologous blood transfn, ABT - Autologous blood transfusion, autologous blood transfusion, autotransfusions, autotransfusion (treatment), Blood--Transfusion, Autologous, Autologous blood transfusion, Abt - autologous blood transfusion, Autotransfusion (procedure), Autotransfusion, NOS, Intravenous autotransfusion each treatment, IV autotransfusion ea.Tx |
| Dutch | autoloogbloedtransfusie, autotransfusie, Autotransfusie, Bloedtransfusie, autologe |
| German | autogene Bluttransfusion, Autotransfusion, Bluttransfusion, autologe |
| Italian | Trasfusione di sangue autologo, Autotrasfusione, Trasfusioni di sangue autologhe, Trasfusione di sangue autologa |
| Portuguese | Transfusão de sangue autólogo, Autotransfusão, Transfusão de Sangue Autóloga |
| Spanish | Transfusión sanguínea autóloga, autotransfusión (procedimiento), autotransfusión, Autotransfusión, Transfusión de Sangre Autóloga |
| Swedish | Autotransfusion |
| Japanese | ｼﾞｺｹﾂﾕｹﾂ, 自家輸血, 自己血輸血, 返血(自己血輸血), 返血法(自己血輸血), 自家輸血法, 自己輸血, 自己輸血法, 輸血-自家, 輸血-自己血 |
| Czech | autotransfúze, krevní transfúze autologní, Autotransfuze, Autologní krevní transfuze, transfuze krve autologní |
| Finnish | Autologinen verensiirto |
| Russian | AUTOTRANSFUZIIA, PERELIVANIE KROVI AUTOLOGICHNOE, АУТОТРАНСФУЗИЯ, ПЕРЕЛИВАНИЕ КРОВИ АУТОЛОГИЧНОЕ |
| French | Transfusion de sang autologue, Autotransfusion, Transfusion sanguine autologue |
| Croatian | TRANSFUZIJA KRVI, AUTOLOGNA |
| Polish | Autotransfuzja, Przetaczanie krwi własnej |
| Hungarian | Autológ vér transzfúzió, Autotranszfúzió |
| Norwegian | Autolog blodtransfusjon, Autologe blodtransfusjoner, Autolog blodoverføring, Autotransfusjon, Blodtransfusjon, autolog, Autolog blodoverføringer, Blodoverføring, autolog |
Ontology: Red Blood Cell Transfusion (C0086252)
| Definition (MSH) | The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor. |
| Concepts | Therapeutic or Preventive Procedure (T061) |
| MSH | D017707 |
| SnomedCT | 116863004 |
| English | Erythrocyte Transfusion, Erythrocyte Transfusions, Transfusion, Erythrocyte, Transfusions, Erythrocyte, Red Blood Cell Transfusions, Transfusion, Red Blood Cell, Transfusions, Red Blood Cell, blood cells red transfusions, transfusion of red blood cells, transfusion erythrocyte, blood cells red transfusion, red blood cell transfusion, Red Blood Cell Transfusion, Erythrocytes--Transfusion, Red blood cells administration by intravascular infusion, Transfusion of red blood cells (procedure), Transfusion of red blood cells |
| Swedish | Erytrocyttransfusion |
| Czech | erytrocyty - transfúze, transfuze erytrocytů |
| Finnish | Punasolusiirto |
| Russian | ERITROTSITOV PERELIVANIE, KRASNYKH KROVIANYKH KLETOK PERELIVANIE, КРАСНЫХ КРОВЯНЫХ КЛЕТОК ПЕРЕЛИВАНИЕ, ЭРИТРОЦИТОВ ПЕРЕЛИВАНИЕ |
| Japanese | 赤血球輸血, 輸血-赤血球 |
| French | Transfusion d'érythrocytes, Transfusion d'hématies, Transfusion érythrocytaire, Transfusion de globules rouges |
| Croatian | ERITROCITI, TRANSFUZIJA |
| Polish | Transfuzja czerwonych krwinek, Przetaczanie erytrocytów |
| Norwegian | Transfusjoner av røde blodceller, Blodoverføring, røde blodceller, Blodoverføringer, røde blodceller, Erytrocyttransfusjon, Transfusjon av røde blodceller |
| Spanish | administración de glóbulos rojos mediante infusión intravascular, transfusión de eritrocitos (procedimiento), transfusión de eritrocitos, transfusión de glóbulos rojos, Transfusión de Eritrocitos, Transfusión de Glóbulos Rojos |
| German | Erythrozytentransfusion, Red Blood Cell Transfusion, Tranfusion, Erythrozyten- |
| Italian | Trasfusione di eritrociti |
| Dutch | Erytrocytentransfusie, Transfusie, erytrocyten- |
| Portuguese | Transfusão de Eritrócitos, Transfusão de Hemácias |
Ontology: Transfusion of packed red blood cells (C0199962)
| Definition (NCI) | The intravenous administration of red blood cells (whole blood without the plasma) into an individual. |
| Definition (NCI_CDISC) | The intravenous administration of red blood cells (whole blood without the plasma) into an individual. |
| Concepts | Therapeutic or Preventive Procedure (T061) |
| SnomedCT | 71493000, 180207008 |
| English | IV blood transfuse packed cell, packed red blood cell transfusion, Packed red blood cell transfusion, blood cell packed red transfusion, blood cells packed red transfusion, prbc transfusion, Transfusion of packed red blood cells, Red Blood Cell Transfusion, Transfusion of PRBC, Intravenous blood transfusion of packed cells, Intravenous blood transfusion of packed cells (procedure), Transfusion of packed red blood cells (procedure), Packed Red Blood Cell Transfusion, PRBC Transfusion |
| Italian | Trasfusione di emazie concentrate |
| Japanese | 濃厚赤血球輸血, ﾉｳｺｳｾｯｹｯｷｭｳﾕｹﾂ |
| Czech | Transfuze erymasy |
| Hungarian | Vörösvértest-massza transzfúzió |
| Spanish | transfusión de PRBC, transfusión de eritrocitos centrifugados, transfusión de glóbulos rojos centrifugados (procedimiento), transfusión de glóbulos rojos centrifugados, transfusión intravenosa de concentrado de eritrocitos (procedimiento), transfusión intravenosa de concentrado de eritrocitos, transfusión intravenosa de eritrocitos desplasmatizados, Transfusión de concentrado de hematíes |
| Portuguese | Transfusão de concentrado de eritrócitos |
| Dutch | rode bloedceltransfusie |
| French | Transfusion de concentré de globules rouges |
| German | Transfusion mit Erythrozytenkonzentrat |
Ontology: Packed red blood cells (C2316467)
| Concepts | Pharmacologic Substance (T121) |
| SnomedCT | 431069006 |
| LNC | LP15236-0 |
| English | Packed red blood cells (product), Packed red blood cells, Packed red blood cells (PRC's), Packed red blood cells (PRBC's), Packed erythrocytes |
| Spanish | concentrado de eritrocitos, concentrado de eritrocitos (producto), concentrado de glóbulos rojos |
