II. Indications
- ST Elevation Myocardial Infarction (STEMI)
- Acute Ischemic Cerebrovascular Accident (off label)
III. Mechanism
-
Recombinant Tissue Plasminogen Activator (rt-PA)
- Serine protease that binds Fibrin and converts Fibrin-bound plasminogen to plasmin
- Plasmin breaks down both Fibrin and Fibrinogen to Fibrin
- Fibrin Degradation Products result, which in turn also act to inhibit Fibrin formation
IV. Dosing
-
ST Elevation Myocardial Infarction (STEMI)
- Give a single IV bolus dose over 5 seconds
- Once reconstituted, IV solution must be used within 8 hours
- Weight <60 kg: 30 mg IV
- Weight 60 to 69 kg: 35 mg IV
- Weight 70 to 79 kg: 40 mg IV
- Weight 80 to 89 kg: 45 mg IV
- Weight >=90 kg: 50 mg IV
V. Safety
- Unknown safety in pregnancy
- Unknown safety in Lactation