II. Mechanism
- Acute phase reactant
-
Clotting Cascade component
- Marker of adequate Hemostasis
- Marker in Trauma of Massive Hemorrhage
- Lower Fibrinogen level correlates with increased blood loss, need for transfusion, and worse outcomes
III. Labs: Normal
- Normal: 200-400 mg/dl (2 to 4 g/L)
IV. Causes: Increased Fibrinogen
- Tissue inflammation or damage
- Acute infection
- Myocardial Infarction
- Medications
- Pregnancy
V. Causes: Decreased Fibrinogen
- Disseminated Intravascular Coagulation
- Primary or Secondary Fibrinolysis
- Liver disease
- Hereditary afibrinogenemia or Hypofibrinogenemia
- Cachexia
- Massive Hemorrhage (Trauma)
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Related Studies
| Definition (GO) | A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. [ISBN:0198547684] |
| Concepts | Cell Component (T026) |
| English | fibrinogen complex, fibrinogen, fibrinogen complex location |
