II. Mechanism
- Acute phase reactant
-
Clotting Cascade component
- Marker of adequate Hemostasis
- Marker in Trauma of Massive Hemorrhage
- Lower Fibrinogen level correlates with increased blood loss, need for transfusion, and worse outcomes
III. Labs: Normal
- Normal: 200-400 mg/dl (2 to 4 g/L)
IV. Causes: Increased Fibrinogen
- Tissue inflammation or damage
- Acute infection
- Myocardial Infarction
- Medications
- Pregnancy
V. Causes: Decreased Fibrinogen
- Disseminated Intravascular Coagulation
- Primary or Secondary Fibrinolysis
- Liver disease
- Hereditary afibrinogenemia or Hypofibrinogenemia
- Cachexia
- Massive Hemorrhage (Trauma)