II. Indications
-
Warfarin use or INR >1.6 and
- Active major bleeding or
- Intracranial Hemorrhage
- Prevent bleeding prior to emergent major procedure or
- Inherited single Clotting Factor deficiency with no available safe factors available
- Acute Disseminated Intravascular Coagulation (DIC) with active bleeding (FFP only, not thawed plasma)
- Microvascular bleeding during Massive Transfusion (>1 Blood Volume or 5L blood in a 70 kg male)
- Replacement fluid for thrombotic microangiopathy
- Hereditary Angioedema (if C1 esterase inhibitor is unavailable)
III. Preparations
- Fresh Frozen Plasma
- Contains all Coagulation Factors
- Thawed Plasma
- May be kept at 33.8 to 42.8 F (1 to 6 C) for up to 5 days
- Contains all Coagulation Factors, but lower levels of factor V and factor VIII
- Do not use in DIC (use FFP instead)
