II. Precautions
- Specific factor recombinant or concentrate products are preferred when available
- Prothrombin Complex Concentrate (PCC4) is preferred in warfarin Anticoagulation and major bleeding
III. Indications
-
Warfarin use or INR >1.6 and PCC4 not available AND
- Active major bleeding or
- Intracranial Hemorrhage
- Prevent bleeding prior to emergent major procedure or
- Inherited single Clotting Factor deficiency with no available safe factors available
- Acute Disseminated Intravascular Coagulation (DIC) with active bleeding (FFP only, not thawed plasma)
- Microvascular bleeding during Massive Transfusion (>1 Blood Volume or 5L blood in a 70 kg male)
- Replacement fluid for Thrombotic Microangiopathy (typically in combination with exchange transfusion)
- Hereditary Angioedema (if C1 esterase inhibitor is unavailable)
- Multifactorial or global Coagulopathy
- Massive Hemorrhage Protocol
IV. Preparations
- Fresh Frozen Plasma
- Contains 200-250 ml per unit
- Contains all Coagulation Factors
- Does not contain Platelets
- Increases Fibrinogen 7-10 mg/dl per unit
- Dosing: 10-20 ml/kg
- Thawed Plasma
- May be kept at 33.8 to 42.8 F (1 to 6 C) for up to 5 days
- Contains all Coagulation Factors, but lower levels of Factor V and Factor VIII
- Do not use in DIC (use FFP instead)
Images: Related links to external sites (from Bing)
Related Studies
| Definition (NCI) | The plasma that is separated from the whole blood and frozen quickly after a blood donation in order to be used for blood transfusions. |
| Definition (MSH) | Freshly frozen PLASMA after the removal of PLATELETS. |
| Concepts | Body Substance (T031) |
| MSH | D010949 |
| SnomedCT | 126244008, 346447007 |
| LNC | LP14557-0 |
| English | Fresh Frozen Plasmas, Frozen Plasma, Fresh, Frozen Plasmas, Fresh, Plasma, Fresh Frozen, Plasmas, Fresh Frozen, fresh frozen plasma, FFP, Fresh frozen plasma, human (product), Fresh frozen plasma, human, FFP - Fresh frozen plasma, Fresh frozen plasma (product), Fresh frozen plasma (substance), Fresh frozen plasma, human (substance), Fresh Frozen Plasma, Fresh frozen plasma |
| Portuguese | Plasma Fresco Congelado |
| Spanish | Plasma Fresco Congelado, plasma fresco humano congelado (producto), plasma fresco humano congelado, plasma fresco congelado (producto), plasma fresco congelado, plasma fresco humano congelado (sustancia) |
| French | Plasma congelé |
| German | Frisches gefrorenes Plasma |
| Italian | Plasma congelato fresco |
| Czech | čerstvá mražená plazma |
| Norwegian | Dypfrosset plasma |
| Dutch | Vers diepgevroren plasma |
Ontology: Transfusion of plasma (C0278347)
| Concepts | Therapeutic or Preventive Procedure (T061) |
| SnomedCT | 151009001, 266807001, 151010006, 13569004 |
| English | Plasma transfusion, transfusions plasma, transfusions plasma (treatment), plasma transfusion, plasma transfusions, transfusion plasma, Plasma transfusion (procedure), Transfusion of plasma, Transfusion of plasma (procedure) |
| Dutch | plasmatransfusie |
| French | Transfusion de plasma |
| German | Transfusion von Plasma |
| Italian | Trasfusione di plasma |
| Portuguese | Transfusão de plasma |
| Spanish | Transfusión de plasma, transfusión de plasma (procedimiento), transfusión de plasma |
| Japanese | 血漿輸血, ｹｯｼｮｳﾕｹﾂ |
| Czech | Transfuze plazmy |
| Hungarian | Plazma transzfúzió |
Ontology: Transfusion of fresh frozen plasma (C1293883)
| Concepts | Therapeutic or Preventive Procedure (T061) |
| SnomedCT | 116861002 |
| English | fresh frozen plasma transfusion (treatment), fresh frozen plasma transfusion, transfusion of fresh frozen plasma, Fresh frozen plasma administration by intravascular infusion, Transfusion of fresh frozen plasma (procedure), Transfusion of fresh frozen plasma |
| Spanish | administración de plasma fresco congelado mediante infusión intravascular, transfusión de plasma fresco congelado (procedimiento), transfusión de plasma fresco congelado |
