II. Pathophysiology
- Donor Lymphocytes survive, engraft and react against host tissue
III. Risk Factors: Severe Immunosuppresion
- Bone Marrow Transplant
- Inherited Cellular Immunity Deficiency
- Severe Lymphopenia (<300 to 500 Lymphocytes/ul)
V. Labs
- Liver function abnormalities (acute liver injury )
-
Pancytopenia
- Complete marrow aplasia may occur within 21 days of transfusion
VI. Management
- Supportive Care
VII. Prevention
VIII. Prognosis
- Fatal in 90% of cases
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Concepts | Disease or Syndrome (T047) |
English | Transfusion associated GVHD, Transfusion associated graft versus host disease |
Spanish | Enfermedad de injerto contra huésped asociada a transfusión |
Portuguese | Transfusão associada a reacção enxerto versus hospedeiro, Doença enxerto contra hospedeiro associada à transfusão |
Italian | Reazione trapianto contro ospite associata a trasfusione, Malattia del trapianto contro l'ospite associata a trasfusione |
German | Posttransfusions-GvHD, Transfusion in Verbindung mit Graft-versus-Host-Erkrankung |
French | Maladie homologue liée à la perfusion, Maladie homologue associée à la perfusion |
Dutch | transfusiegeassocieerde graft-versus-host-ziekte, transfusiegeassocieerde GVHD |
Czech | Reakce štěpu proti hostiteli související s transfuzí, Reakce štěpu proti hostiteli související s transfúzí |
Japanese | ユケツゴイショクヘンタイシュクシュビョウ, 輸血後移植片対宿主病, 輸血後GVHD, ユケツゴGVHD |
Hungarian | Transzfúzióhoz társuló GVHD, Transzfúzióval összefüggő graft versus host betegség |