Transfusion Associated Graft Versus Host Disease

Aka: Transfusion Associated Graft Versus Host Disease, TAGVHD

II. Pathophysiology

  1. Donor Lymphocytes survive, engraft and react against host tissue

III. Risk Factors: Severe Immunosuppresion

  1. Bone Marrow Transplant
  2. Inherited Cellular Immunity Deficiency
  3. Severe Lymphopenia (<300 to 500 Lymphocytes/ul)

IV. Signs

  1. Onset within 5-10 days of transfusion
  2. Fever
  3. Rash
  4. Nausea
  5. Vomiting
  6. Diarrhea

V. Labs

  1. Liver function abnormalities (acute liver injury )
  2. Pancytopenia
    1. Complete marrow aplasia may occur within 21 days of transfusion

VI. Management

  1. Supportive Care

VII. Prevention

  1. Blood Product Irradiation
  2. Blood Product Pathogen Inactivation

VIII. Prognosis

  1. Fatal in 90% of cases

IX. References

  1. Raval (2020) Am Fam Physician 102(1):30-8 [PubMed]
  2. Sharma (2011) Am Fam Physician 83(6): 719-24 [PubMed]

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Related Studies

Ontology: Transfusion associated graft versus host disease (C1328551)

Concepts Disease or Syndrome (T047)
English Transfusion associated GVHD, Transfusion associated graft versus host disease
Spanish Enfermedad de injerto contra huésped asociada a transfusión
Portuguese Transfusão associada a reacção enxerto versus hospedeiro, Doença enxerto contra hospedeiro associada à transfusão
Italian Reazione trapianto contro ospite associata a trasfusione, Malattia del trapianto contro l'ospite associata a trasfusione
German Posttransfusions-GvHD, Transfusion in Verbindung mit Graft-versus-Host-Erkrankung
French Maladie homologue liée à la perfusion, Maladie homologue associée à la perfusion
Dutch transfusiegeassocieerde graft-versus-host-ziekte, transfusiegeassocieerde GVHD
Czech Reakce štěpu proti hostiteli související s transfuzí, Reakce štěpu proti hostiteli související s transfúzí
Japanese ﾕｹﾂｺﾞｲｼｮｸﾍﾝﾀｲｼｭｸｼｭﾋﾞｮｳ, 輸血後移植片対宿主病, 輸血後ＧＶＨＤ, ﾕｹﾂｺﾞGVHD
Hungarian Transzfúzióhoz társuló GVHD, Transzfúzióval összefüggő graft versus host betegség
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pharmacology

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