Ticlopidine

Aka: Ticlopidine, Ticlid

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II. Indications

  1. Replaced by other Platelet ADP Receptor Antagonist (e.g. Clopidogrel) due to Ticlopidine toxicity
  2. Historic uses (rare use in the United States)
    1. Cerebrovascular Accident Prevention
    2. Prevention of cardiac stent thrombosis

III. Mechanism

  1. Blocks Platelet ADP
  2. Inhibits Platelet aggregation

IV. Adverse Effects

  1. Thrombotic Thrombocytopenic Purpura (TTP)
  2. Neutropenia

V. Monitoring

  1. Complete Blood Count every 2 weeks for the first 3 months of use

VI. Dosing

  1. Avoid Ticlopidine if possible
  2. Replaceed with other Platelet ADP Receptor Antagonist such as Clopidogrel (Plavix) due to adverse effects
  3. Take 250 mg orally twice daily with food

VII. Resources

  1. Ticlopidine (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=77d619f8-05a3-408a-a6f8-1511694b6a24

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