II. Indications
- Replaced by other Platelet ADP Receptor Antagonist (e.g. Clopidogrel) due to Ticlopidine toxicity
- Historic uses (rare use in the United States)
- Cerebrovascular Accident Prevention
- Prevention of cardiac stent thrombosis
IV. Adverse Effects
V. Monitoring
- Complete Blood Count every 2 weeks for the first 3 months of use
VI. Dosing
- Avoid Ticlopidine if possible
- Replaceed with other Platelet ADP Receptor Antagonist such as Clopidogrel (Plavix) due to adverse effects
- Take 250 mg orally twice daily with food
VII. Resources
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Related Studies
| Definition (NCI) | A thienopyridine derivative with anticoagulant activity. Ticlopidine inhibits adenosine-diphosphate (ADP) binding to its platelet receptor. This prevents ADP activation and inhibits platelet expression of the glycoprotein (GP) IIb/IIIA receptors, binding of fibrinogen to platelet glycoprotein GP IIb-IIIa and platelet-platelet interaction. This results in increased bleeding time. |
| Definition (MSH) | An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D013988 |
| SnomedCT | 108971003, 386950000 |
| LNC | LP15009-1, MTHU001495 |
| English | Ticlopidine, Thieno(3,2-c)pyridine, 5-((2-chlorophenyl)methyl)-4,5,6,7-tetrahydro-, ticlopidine (medication), Ticlopidine [Chemical/Ingredient], ticlopidine, TICLOPIDINE, Ticlopidine (product), Ticlopidine (substance) |
| Swedish | Tiklopidin |
| Czech | tiklopidin |
| Finnish | Tiklopidiini |
| Russian | TIKLOPIDIN, ТИКЛОПИДИН |
| Japanese | チクロピジン |
| Polish | Tyklopidyna, Tiklopidyna |
| Croatian | Tiklopidin |
| Spanish | ticlopidina (producto), ticlopidina (sustancia), ticlopidina, Ticlopidina |
| French | Ticlopidine |
| German | Ticlopidin |
| Italian | Ticlopidina |
| Portuguese | Ticlopidina |
Ontology: Ticlid (C0733418)
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D013988 |
| English | Roche Brand of Ticlopidine Hydrochloride, ticlid, Ticlid |
