II. Mechanism

  1. Blocks Platelet ADP
  2. Inhibits Platelet aggregation

III. Indications

  1. Consider other agents (e.g. Plavix) due to toxicity
  2. Cerebrovascular Accident Prevention

V. Dosing (Avoid if possible)

  1. Replaceed with other Platelet ADP Receptor Antagonist such as Clopidogrel (Plavix) due to adverse effects
  2. Ticlid 250 mg orally twice daily with food

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Ontology: Ticlopidine (C0040207)

Definition (NCI) A thienopyridine derivative with anticoagulant activity. Ticlopidine inhibits adenosine-diphosphate (ADP) binding to its platelet receptor. This prevents ADP activation and inhibits platelet expression of the glycoprotein (GP) IIb/IIIA receptors, binding of fibrinogen to platelet glycoprotein GP IIb-IIIa and platelet-platelet interaction. This results in increased bleeding time.
Definition (MSH) An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D013988
SnomedCT 108971003, 386950000
LNC LP15009-1, MTHU001495
English Ticlopidine, Thieno(3,2-c)pyridine, 5-((2-chlorophenyl)methyl)-4,5,6,7-tetrahydro-, ticlopidine (medication), Ticlopidine [Chemical/Ingredient], ticlopidine, TICLOPIDINE, Ticlopidine (product), Ticlopidine (substance)
Swedish Tiklopidin
Czech tiklopidin
Finnish Tiklopidiini
Japanese チクロピジン
Polish Tyklopidyna, Tiklopidyna
Croatian Tiklopidin
Spanish ticlopidina (producto), ticlopidina (sustancia), ticlopidina, Ticlopidina
French Ticlopidine
German Ticlopidin
Italian Ticlopidina
Portuguese Ticlopidina

Ontology: Ticlid (C0733418)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D013988
English Roche Brand of Ticlopidine Hydrochloride, ticlid, Ticlid