II. Indications
- Acute Lymphoblastic Leukemia (Philadelphia Chromosome negative, relapsing)
III. Contraindications
- Do NOT use via any route other than intravenously
- Do NOT confuse with standard Vincristine
IV. Mechanism
- See Mitotic Inhibitor Chemotherapy
- Liposomal formulation of Vincristine
- Reduced toxicity and better efficacy
-
Vincristine, like Vinblastine, is a natural Vinca Alkaloid with antineoplastic activity
- Isolated from the periwinkle plant (Vinca rosea Linn)
-
Vincristine is an antitubular agent
- Binds tubulin and inhibits microtubule formation
- Disrupts mitotic spindle formation
- Arrests Cell Cycle in G2/M phase
- Other possible activity
- Interferes with metabolism of Amino Acids cAMP, glutathione
- Interferes with calmodulin-dependent Calcium transport ATPase activity
- Interferes with biosynthesis of Nucleic Acids and lipids
V. Medications
- Vincristine Sulfate Liposome (Marqibo) available as an injection kit
VI. Dosing
- See other references for disease specific dosing protocols
- Only use intravenously (other routes may be lethal)
VII. Pharmacokinetics
- Hepatic metabolism
- Excreted in the stool
VIII. Adverse Effects
- See Vincristine
IX. Safety
- Avoid in Lactation
- Avoid in pregnancy (all trimesters)
- Use reliable Contraception
X. Resources
- Vincristine Injection Solution (DailyMed)
- Vincristine (StatPearls)
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Related Studies
Definition (NCI) | A liposomal formulation of Vincristine designed to reduce toxicity and improve efficacy. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI) |
Concepts | Lipid (T119) , Pharmacologic Substance (T121) |
SnomedCT | 425643003, 426490000 |
English | Vincristine liposomal, Vincristine liposome (substance), Vincristine liposomal (product), Vincristine liposome, vincristine liposome, vinCRIStine liposome, Lipid-Encapsulated Vincristine, Liposomal Vincristine, Vincacine, Vincristine Liposomal, Vincristine Liposome, Vincristine, Liposomal, liposomal vincristine, vincristine liposomal |
Spanish | vincristina liposómica (sustancia), vincristina liposómica, vincristina liposómica (producto) |