II. Indications

III. Contraindications

  1. Do NOT use via any route other than intravenously
  2. Do NOT confuse with standard Vincristine

IV. Mechanism

  1. See Mitotic Inhibitor Chemotherapy
  2. Liposomal formulation of Vincristine
    1. Reduced toxicity and better efficacy
  3. Vincristine, like Vinblastine, is a natural Vinca Alkaloid with antineoplastic activity
    1. Isolated from the periwinkle plant (Vinca rosea Linn)
  4. Vincristine is an antitubular agent
    1. Binds tubulin and inhibits microtubule formation
    2. Disrupts mitotic spindle formation
    3. Arrests cell cycle in G2/M phase
  5. Other possible activity
    1. Interferes with metabolism of Amino Acids cAMP, glutathione
    2. Interferes with calmodulin-dependent Calcium transport ATPase activity
    3. Interferes with biosynthesis of Nucleic Acids and lipids

V. Medications

  1. Vincristine Sulfate Liposome (Marqibo) available as an injection kit

VI. Dosing

  1. See other references for disease specific dosing protocols
  2. Only use intravenously (other routes may be lethal)

VII. Pharmacokinetics

  1. Hepatic metabolism
  2. Excreted in the stool

VIII. Adverse Effects

IX. Safety

  1. Avoid in Lactation
  2. Avoid in pregnancy (all trimesters)
    1. Use reliable Contraception

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