II. Definitions

  1. Cyclin-Dependent Kinase (CDK)
    1. Group of Protein kinase enzymes (Serine/Threonine kinase) that regulate Cell Cycle phases
    2. CDKs are composed of subunits including a catalytic subunit and an activating cyclin subunit

III. Physiology: Cell Cycle

  1. Interphase
    1. General
      1. Interval between cell divisions (includes G1, G0 and G2 Phases, as well as S Phase)
      2. Cell readies for Mitosis during Interphase, performing DNA Replication (S Phase)
      3. Chromosomes cannot be individually recognized during Interphase
    2. G1 Phase (Gap 1)
      1. Preparation for DNA synthesis (S-Phase) and Mitosis (M-Phase)
      2. Cells grow larger with increased cytoplasm, and organelles are duplicated
      3. Regulated by the availability of nutrients and growth factors, and suppressed by inhibitors
      4. Composed of 4 subphases
        1. Competence (response to growth factors)
        2. Entry (G1a)
        3. Progression (G1b)
        4. Assembly (G1c)
    3. G0 Phase (Gap 0)
      1. Following G1 phase, cells may further differentiate and not divide
      2. Cells may remain in G0 Phase for long periods of time
    4. Synthesis Phase (S-Phase)
      1. See DNA Replication
      2. Preparation for Mitosis and cell division
        1. Entire nuclear DNA content is replicated
        2. Centrioles (microtubule organizing structure) are duplicated
    5. G2 Phase (Gap 2)
      1. Gap following DNA synthesis (S-Phase) and preceding Mitosis (M-Phase)
      2. Chromosomes are tetraploid in G2 phase (four of each of 23 Chromosomes)
        1. Humans are otherwise diploid (pairs of Chromosomes known as 2N, totaling 46)
  2. Mitosis (M-Phase)
    1. General
      1. Cell Cycle phase in which nuclear division occurs
      2. Mitosis is in turn composed of 4 phases: Prophase, Metaphase, Anaphase and Telophase
    2. Phase 1: Prophase
      1. Chromosomes condense into individually differentiated structures
      2. Centrioles migrate toward the cellular poles
    3. Phase 2: Metaphase
      1. Chromosomes line up across the equatorial plane of the spindle, before separation
    4. Phase 3: Anaphase
      1. Chromosomes separate and migrate towards the poles of the spindle
    5. Phase 4: Telophase
      1. Chromosomes arrive at the poles of the cell
      2. Also marks the start of cytoplasm division

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Ontology: Mitotic Anaphase (C0002788)

Definition (GO) The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle. [GOC:mtg_cell_cycle]
Definition (NCI) The third phase of mitosis during which the two groups of daughter chromosomes separate and move along the fibers of the central spindle, each toward one of the asters, forming the diaster.
Concepts Cell Function (T043)
English mitotic anaphase, Anaphase, Mitotic Anaphase

Ontology: Cell Cycle (C0007586)

Definition (GO) The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. [GOC:go_curators, GOC:mtg_cell_cycle]
Definition (NCI_KEGG) Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
Definition (MSH) The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Definition (CSP) changes that take place in a cell during the period between its formation as one of the products of cell division and its own subsequent division.
Concepts Cell Function (T043)
MSH D002453
English Cell Cycles, Cycle, Cell, Cycles, Cell, cell-division cycle, cell division cycle, cell cycle, cycle cell, cell cycle division, cells cycle, Cell cycle, Cell Division Cycles, Cycle, Cell Division, Cycles, Cell Division, Division Cycles, Cell, Cell Division Cycle, Division Cycle, Cell, Cell Cycle Pathway, Cell Cycle
Swedish Cellcykel
Czech buněčný cyklus
Finnish Solukierto
French Cycle de division cellulaire, Cycle cellulaire
Russian TSITOKINETIKA, KLETOCHNYI TSIKL, КЛЕТОЧНЫЙ ЦИКЛ, ЦИТОКИНЕТИКА
Italian Ciclo di divisione cellulare, Ciclo cellulare
Croatian STANIČNI CIKLUS
Polish Cykl komórkowy
Japanese 細胞サイクル, 細胞周期, 細胞分裂周期
Norwegian Not Translated[Cell Cycle]
German Zellzyklus
Dutch Celcyclus, Cyclus, cel-
Portuguese Ciclo Celular
Spanish Ciclo Celular

Ontology: Interphase (C0021798)

Definition (MSH) The interval between two successive CELL DIVISIONS during which the CHROMOSOMES are not individually distinguishable. It is composed of the G phases (G1 PHASE; G0 PHASE; G2 PHASE) and S PHASE (when DNA replication occurs).
Definition (GO) The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs. [GOC:mtg_cell_cycle]
Definition (NCI) The interval between two successive cell divisions during which the chromosomes are not individually distinguishable. Interphase is considered the resting stage of the cell.
Concepts Cell Function (T043)
MSH D007399
SnomedCT 5741007
LNC LA14024-6
English Interphase, Interphases, karyostasis, Interphase, function, interphase, Interphase Process, Interphase, function (observable entity), Interphase (function)
Swedish Interfas
Czech interfáze
Finnish Interfaasi
Russian G FAZA, G PERIODY, FAZA POKOIA, INTERFAZA, G ПЕРИОДЫ, G ФАЗА, ИНТЕРФАЗА, ФАЗА ПОКОЯ
Polish Interfaza
Spanish interfase (entidad observable), interfase (función), interfase, Interfase
French Interphase
German Interphase, Ruhephase
Italian Interfase
Dutch Interfase
Portuguese Interfase

Ontology: Mitotic Metaphase (C0025564)

Definition (GO) The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle. [GOC:mtg_cell_cycle]
Definition (NCI) The second phase of mitosis, in which the chromosomes line up across the equatorial plane of the spindle prior to separation.
Concepts Cell Function (T043)
English mitotic metaphase, metaphase, Metaphase, Metaphase Process, Mitotic Metaphase

Ontology: Mitosis (C0026255)

Definition (GO) A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
Definition (GO) A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase. [GOC:mtg_cell_cycle]
Definition (NCI) The last cell cycle stage during which the replicated daughter chromosomes separate in to separate nuclei; cytokinesis then occurs to produce separate daughter cells. It is divided into Prophase, Metaphase, Anaphase, and Telophase.
Definition (NCI_NCI-GLOSS) The process by which a single parent cell divides to make two new daughter cells. Each daughter cell receives a complete set of chromosomes from the parent cell. This process allows the body to grow and replace cells.
Definition (NCI) The usual process of somatic reproduction of cells consisting of a sequence of modifications of the nucleus that result in the formation of two daughter cells with exactly the same chromosome and DNA content as that of the original cell. It is the process by which the body grows and replaces cells and is divided into four phases. In Prophase, paired chromosomes form, nuclear membrane disappears, the achromatic spindle appears, and polar bodies form. In Metaphase, chromosomes are arranged in the equatorial plane of the central spindle to form the monaster and chromosomes separate into exactly similar halves. In Anaphase, the two groups of daughter chromosomes separate and move along the fibers of the central spindle, each toward one of the asters, forming the diaster. In Telophase, the daughter chromosomes resolve themselves into a reticulum, the daughter nuclei are formed, and the cytoplasm divides forming two complete daughter cells.
Definition (MSH) A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.
Concepts Cell Function (T043)
MSH D008938
SnomedCT 7041004
English Mitoses, M-phase, M phase, Mitosis, function, M phase (cell cycle), karyokinesis, mitoses, mitosis, M Phase, M Phase Process, Mitotic Process, mitotic cycle, Mitosis, function (observable entity), Mitosis (function), Mitosis, M Stage, Mitosis Stage
Swedish Mitos
Czech mitóza
Finnish Mitoosi
Russian MITOZ, M PERIOD, M ПЕРИОД, МИТОЗ
Japanese M相-有糸分裂, 有糸分裂, M期-有糸分裂, 有糸核分裂, 間接分裂
Polish Mitoza
Norwegian Not Translated[Mitosis]
Spanish FASE M MITÓTICA, mitosis (entidad observable), mitosis (función), mitosis, Mitosis
Portuguese FASE M MITÓTICA, Mitose
French Mitose
German Mitose
Italian Mitosi
Dutch Mitose

Ontology: Prophase (C0033464)

Definition (MSH) The first phase of cell nucleus division, in which the CHROMOSOMES become visible, the CELL NUCLEUS starts to lose its identity, the SPINDLE APPARATUS appears, and the CENTRIOLES migrate toward opposite poles.
Definition (GO) The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. [GOC:mtg_cell_cycle]
Concepts Temporal Concept (T079)
MSH D011418
SnomedCT 51533001
English Prophases, Prophase, function, prophase, Prophase, function (observable entity), Prophase (function), Prophase
Swedish Profas
Czech profáze
Finnish Profaasi
Russian PROFAZA, ПРОФАЗА
Polish Profaza
Norwegian Not Translated[Prophase]
Spanish profase (entidad observable), profase (función), profase, Profase
French Prophase
German Prophase
Italian Profase
Dutch Profase
Portuguese Prófase

Ontology: telophase (C0039465)

Definition (GO) The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. [GOC:mtg_cell_cycle]
Definition (MSH) The final phase of cell nucleus division following ANAPHASE, in which two daughter nuclei are formed, the CYTOPLASM completes division, and the CHROMOSOMES lose their distinctness and are transformed into CHROMATIN threads.
Concepts Temporal Concept (T079)
MSH D013692
SnomedCT 4186006
English Telophase, Telophases, Telophase, function, Telophase, function (observable entity), Telophase (function), telophase
Swedish Telofas
Czech telofáze
Finnish Telofaasi
Russian TELOFAZA, ТЕЛОФАЗА
Polish Telofaza
Norwegian Telofase
Spanish telofase (entidad observable), telofase (función), telofase, Telofase
French Télophase
German Telophase
Italian Telofase
Dutch Telofase
Portuguese Telófase

Ontology: G0 Phase (C0079394)

Definition (MSH) A quiescent state of cells during G1 PHASE.
Concepts Temporal Concept (T079)
MSH D016192
English G0 Phase, G0 Phases, Phase, G0, Phases, G0, G A 00 PHASE, G0 state, G0 phase
Swedish G0-fas
Czech G0 fáze
Finnish G0-faasi
Russian G0 FAZA, FAZA G0, G0 ФАЗА, ФАЗА G0
German G A 00 PHASE, G0-Phase
Polish Faza G0
French Phase G0
Italian Fase G0
Dutch Fase, G0-, G0-fase
Portuguese Fase G0
Spanish Fase G0

Ontology: G1 Phase (C0079395)

Definition (GO) The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis. [GOC:mtg_cell_cycle]
Definition (NCI) Phase of the cell cycle preceding DNA synthesis (Gap 1 phase). The subphases of G1 include competence, entry (G1a), progression (G1b), and assembly (G1c), based on the effects of limiting growth factors, nutrients, or inhibitors.
Definition (MSH) The period of the CELL CYCLE preceding DNA REPLICATION in S PHASE. Subphases of G1 include "competence" (to respond to growth factors), G1a (entry into G1), G1b (progression), and G1c (assembly). Progression through the G1 subphases is effected by limiting growth factors, nutrients, or inhibitors.
Concepts Temporal Concept (T079)
MSH D016193
English G1 Phases, Phase, G1, Phases, G1, G1 phase, G A 01 PHASE, G1 period, G1 Phase Process, First Gap Phases, First Gap Phase, Gap Phase 1, Gap Phase, First, Gap Phases, First, Phase 1, Gap, Phase, First Gap, Phases, First Gap, 1, Gap Phase, G1, Gap 1 Phase, G1 Phase
Swedish G1-fas
Czech G1 fáze
Finnish G1-faasi
French Phase gap 1, Phase G1
Russian G1 FAZA, FAZA G1, G1 ФАЗА, ФАЗА G1
Japanese G1期, 細胞周期G1期
Italian Prima fase gap, Fase gap 1, Fase G1
German G A 01 PHASE, G1-Phase
Polish Faza G1
Dutch Fase, G1-, G1-fase
Portuguese Fase G1
Spanish Fase G1

Ontology: G2 Phase (C0079396)

Definition (GO) The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis). [GOC:mtg_cell_cycle]
Definition (GO) The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis. [GOC:mtg_cell_cycle]
Definition (NCI) Phase of the cell cycle following DNA synthesis and preceding mitosis (Gap 2 phase). The chromosomes are tetraploid in this phase.
Definition (MSH) The period of the CELL CYCLE following DNA synthesis (S PHASE) and preceding M PHASE (cell division phase). The CHROMOSOMES are tetraploid in this point.
Concepts Temporal Concept (T079)
MSH D016195
English G2 Phases, Phase, G2, Phases, G2, G2 phase, G A 02 PHASE, G2 period, G2 Phase Process, mitotic G2 phase, G2 phase of mitotic cell cycle, Gap Phase 2, Gap Phase, Second, Gap Phases, Second, 2, Gap Phase, Phase 2, Gap, Phase, Second Gap, Phases, Second Gap, Second Gap Phases, Second Gap Phase, G2, Gap 2 Phase, G2 Phase
Swedish G2-fas
Czech G2 fáze
Finnish G2-faasi
French Phase gap 2, Phase G2
Russian FAZA G2, G2 FAZA, G2 ФАЗА, ФАЗА G2
Japanese G2期, 細胞周期G2期
Italian Fase gap 2, Seconda fase gap, Fase G2
German G A 02 PHASE, G2-Phase
Polish Faza G2
Dutch Fase, G2-, G2-fase
Portuguese Fase G2
Spanish Fase G2

Ontology: S Phase (C0080129)

Definition (GO) The cell cycle phase, following G1, during which DNA synthesis takes place. [GOC:mtg_cell_cycle]
Definition (NCI) Phase of the cell cycle following G1 and preceding G2 when the entire DNA content of the nucleus is replicated (Synthesis phase). It is achieved by bidirectional replication at multiple sites along each chromosome.
Definition (MSH) Phase of the CELL CYCLE following G1 and preceding G2 when the entire DNA content of the nucleus is replicated. It is achieved by bidirectional replication at multiple sites along each chromosome.
Concepts Temporal Concept (T079)
MSH D016196
English Period, S, Periods, S, Phase, S, Phases, S, S Period, S Periods, S Phase, S Phases, S phase, S phase (cell cycle), s phase, S Phase Process, S-phase, Synthesis Period, Synthesis Phase
Swedish S-fas
Czech S fáze
Finnish S-vaihe
French Phase de synthèse de l'ADN, Phase S du cycle cellulaire, Phase de réplication de l'ADN, Phase S
Russian FAZA PROMEZHUTOCHNAIA, S PERIOD, S FAZA, S ПЕРИОД, S ФАЗА, ФАЗА ПРОМЕЖУТОЧНАЯ
Japanese S期, S相
Italian Periodo S, Fase S
Polish Faza S
German S-Phase
Dutch Fase, S-, S-fase
Portuguese Fase S
Spanish Fase S

Ontology: Cyclin-Dependent Kinases (C0243045)

Definition (NCI) Cyclin-dependent kinases are eukaryotic, phosphoregulated protein kinases that associate with cyclins to control cell cycle progression.
Definition (CSP) nonEC.
Definition (MSH) Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH D018844
English Cyclin Dependent Kinases, Cyclin Dependent Protein Kinases, Cyclin-Dependent Protein Kinases, cdk Proteins, Cyclin-Dependent Kinases [Chemical/Ingredient], cyclin dependent kinase, cyclin dependent kinases, cyclin-dependent kinases, CDK, Cyclin-dependent kinases, Cyclin-Dependent Kinases, Cyclin Dependent Kinase, Cyclin-Dependent Kinase
Swedish Cyklinberoende kinaser
Czech cdk proteiny, cyklin-dependentní kinasy, kinasy závislé na cyklinu
Finnish Cdk
Russian TSIKLIN-ZAVISIMYE KINAZY, CDK BELKI, CDK БЕЛКИ, ЦИКЛИН-ЗАВИСИМЫЕ КИНАЗЫ
French Protéine-kinases dépendantes des cyclines, Kinases dépendantes de la cycline, Protéine-kinases dépendantes de la cycline, Protéines kinases dépendantes de la cycline, Kinases dépendantes des cyclines, Cyclin-dependent kinases, Kinases cycline-dépendantes, Protéines CDK
Italian Chinasi ciclino dipendenti, Proteinchinasi ciclina dipendenti, Proteinchinasi ciclino dipendenti, Proteina cinasi ciclina-dipendente, Cinasi ciclina-dipendenti, Proteine CDK, Chinasi ciclina dipendenti, Chinasi ciclino-dipendenti
Polish Kinazy cyklinozależne
Croatian KINAZE OVISNE O CIKLINU, CDK PROTEINI
Japanese サイクリン依存性キナーゼ, cdkタンパク質, cdk蛋白質
Portuguese Quinases Dependentes de Ciclina, Proteínas cdk, Quinases Ciclina-Dependentes
German Cdk-Proteine, Cyclin-abhängige Kinasen
Spanish Quinasas Ciclina-Dependientes, Proteínas cdk

Ontology: Mitotic Prophase (C1155732)

Definition (GO) The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. [GOC:mtg_cell_cycle]
Definition (NCI) The first phase of mitosis, in which the chromosomes become visible, the nucleus starts to lose its identity, the spindle appears, and the centrioles migrate toward opposite poles.
Concepts Cell Function (T043)
English mitotic prophase, Prophase, Prophase Process, Mitotic Prophase

Ontology: Mitotic Telophase (C1155740)

Definition (GO) The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. [GOC:mtg_cell_cycle]
Definition (NCI) The final phase of cell division, in which two daughter nuclei are formed, the cytoplasm divides, and the chromosomes lose their distinctness and are transformed into chromatin networks.
Concepts Cell Function (T043)
English mitotic telophase, Telophase, Mitotic Telophase

Ontology: M Phase, Mitotic (C1450044)

Definition (GO) A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle. [GOC:mtg_cell_cycle]
Concepts Cell Function (T043)
MSH D008938
English M-phase of mitotic cell cycle, M phase of mitotic cell cycle, mitotic M phase, Mitotic M Phase, M Phase, Mitotic, Mitotic M Phases, Phase, Mitotic M, Phases, Mitotic M, M Phases, Mitotic
German M-Phase, mitotisch, Mitotische M-Phase
French Phase mitotique, Phase M (mitose)

Ontology: Metaphase (C1621812)

Definition (MSH) The phase of cell nucleus division following PROMETAPHASE, in which the CHROMOSOMES line up across the equatorial plane of the SPINDLE APPARATUS prior to separation.
Definition (GO) The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell. [GOC:mtg_cell_cycle]
Concepts Cell Function (T043)
MSH D008677
SnomedCT 74399001
LNC LA14023-8
English Metaphases, metaphase, Metaphase, function, Metaphase, function (observable entity), Metaphase (function), Metaphase
Swedish Metafas
Czech metafáze
Finnish Metafaasi
Russian METAFAZA, МЕТАФАЗА
Polish Metafaza
Spanish metafase (entidad observable), metafase (función), metafase, Metafase
French Métaphase
German Metaphase
Italian Metafase
Dutch Metafase
Portuguese Metáfase

Ontology: Anaphase (C1622911)

Definition (GO) The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle. [GOC:mtg_cell_cycle]
Definition (MSH) The phase of cell nucleus division following METAPHASE, in which the CHROMATIDS separate and migrate to opposite poles of the spindle.
Concepts Cell Function (T043)
MSH D000705
SnomedCT 25819003
English Anaphases, anaphase, Anaphase, function, Anaphase, function (observable entity), Anaphase (function), Anaphase
Swedish Anafas
Czech anafáze
Finnish Anafaasi
Russian ANAFAZA, АНАФАЗА
Polish Anafaza
Spanish anafase (entidad observable), anafase (función), anafase, Anafase
French Anaphase
German Anaphase
Italian Anafase
Dutch Anafase
Portuguese Anáfase