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Definition (NCI_NCI-GLOSS)
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A drug used to treat certain types of ovarian cancer, lung cancer, and cervical cancer. Topotecan is a type of topoisomerase inhibitor.
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Definition (NCI)
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A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery.
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Definition (CSP)
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antineoplastic drug which acts as a DNA topoisomerase inhibitor.
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Definition (MSH)
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An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D019772
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| SnomedCT |
108779005, 372536007 |
| LNC |
LP172582-1, MTHU046380 |
| English |
9 Dimethylaminomethyl 10 hydroxycamptothecin, 9-Dimethylaminomethyl-10-hydroxycamptothecin, Hycamtamine, (s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione, 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin, Topotecan Lactone, Topotecan [Chemical/Ingredient], topotecan, TOPOTECAN, Topotecan (product), Topotecan (substance), hycamptamine, TOPO, Topotecan, Hycamptamine |
| Swedish |
Topotecan
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| Czech |
topotekan
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| Finnish |
Topotekaani
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| Russian |
TOPOTEKAN, ТОПОТЕКАН |
| Japanese |
ハイカムチン注射用, ハイカムチン, ノギテカン, 塩酸ノギテカン, トポテカン, 塩酸トポテカン, ノギテカン塩酸塩, トポテカン塩酸塩 |
| Spanish |
topotecano (producto), topotecano, topotecán (producto), topotecano (sustancia), topotecán (sustancia), topotecán, Topotecan |
| French |
9-diméthylaminométhyl-10-hydroxycamptothécine, Hycamtamine, 9-(diméthylamino)méthyl-10-hydroxycamptothécine, Topotécane |
| Polish |
Topotekan
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| German |
Topotecan
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| Italian |
Topotecan
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| Portuguese |
Topotecan
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