II. Indications

  1. FDA Approved (in combination regimens)
    1. Hairy Cell Leukemia
  2. Off-Label Use
    1. Graft Versus Host Disease (acute or chronic)
    2. Chronic Lymphocytic Leukemia (CLL)
    3. Cutaneous T-Cell Lymphoma
    4. Mycosis Fungoides
    5. T-Cell Prolymphocytic Leukemia

III. Mechanism

  1. Purine Nucleotide analog
    1. Extracted from bacterium Streptomyces antibioticus
    2. More active in lymph cells, esp. T-Cells, and esp. malignant T Cells and CD26+ Lymphocytes
  2. Inhibits adenine deaminase (ADA)
    1. Blocks Purine metabolism
    2. Increases intracellular dATP levels, inhibiting ribonucleotide reductase
    3. Inhibits DNA synthesis
    4. Inhibits RNA synthesis

IV. Medications

  1. Pentostatin powder for IV Solution in 10 mg vials

V. Dosing

  1. See other references for disease specific dosing protocols

VI. Adverse Effects

  1. Alopecia
  2. Myelosuppression
  3. Hepatotoxicity
  4. Impaired future fertility
  5. Lung Toxicity
  6. Nephrotoxicity
  7. Neurotoxicity (CNS)
  8. Rash (severe)

VII. Safety

  1. Avoid in Pregnancy (any trimester)
    1. Use reliable Contraception
  2. Avoid in Lactation
  3. Monitoring
    1. Complete Blood Count
    2. Renal Function Tests

IX. References

  1. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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