II. Indications
- FDA Approved
- Off-label
- Mantle Cell Lymphoma
- Multiple Myeloma
- B-Cell Non-Hodgkin Lymphoma
- Waldenstrom Macroglobulinemia
III. Mechanism
- See Alkylating Agent
- Nitrogen Mustard derived antineoplastic Alkylating Agent
-
Mechlorethamine derivative with alkylator and antimetabolite properties
- Alkylating group (cross-links DNA)
- Purine Analogue (DNA, RNA and Protein synthesis inhibitor)
- Vesicant
IV. Medications
- Treanda 25 mg and 100 mg vials containing powder for preparation of IV solution
- Bendeka 100 mg/4 ml IV solution
V. Dosing
- See other references for disease specific dosing protocols
VI. Pharmacokinetics
- Hepatic metabolism to both active and inactive metabolites
VII. Safety
- Avoid in Lactation
- Avoid in pregnancy (contraindicated in all trimesters)
- Teratogenic and adverse outcomes
- Use reliable Contraception
- Monitoring
VIII. Adverse Effects
- Bone Marrow Suppression
- Nephrotoxicity
- Hepatotoxicity
- Hypersensitivity and Drug Reactions
IX. Resources
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Related Studies
Definition (NCI) | A bifunctional mechlorethamine derivative with alkylating and antimetabolite activities. Although the exact mechanism of action of bendamustine is unknown, this agent appears to alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and eventually the induction of apoptosis. |
Definition (NCI_NCI-GLOSS) | The active ingredient in a drug that is used to treat chronic lymphocytic leukemia (CLL), to treat slow-growing B-cell non-Hodgkin lymphoma (NHL) that has gotten worse within 6 months of treatment with other anticancer drugs, and is being studied in the treatment of other types of cancer. Bendamustine may damage the DNA in cancer cells and cause them to die. It is a type of alkylating agent and a type of antimetabolite. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C001758 |
SnomedCT | 427812009, 428012008 |
English | bendamustin, bendamustine, Bendamustine, Bendamustine (product), Bendamustine (substance), BENDAMUSTINE, 5-(Bis(2-chloroethyl)amino)-1-methyl-2-benzimidazolebutyric Acid, bendamustine [Chemical/Ingredient], bendamustine (medication), gamma-(1-methyl-5-bis(beta-chloroethyl)aminobenzimidazole)-(2)-butyric acid |
Spanish | bendamustina, bendamustina (sustancia), bendamustina (producto) |
Ontology: Bendamustine hydrochloride (C0772139)
Definition (NCI) | The hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and, subsequently, apoptosis. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent may be more efficacious and less susceptible to drug resistance than other alkylators. |
Definition (NCI_NCI-GLOSS) | A drug used to treat chronic lymphocytic leukemia (CLL). It is also used to treat slow-growing B-cell non-Hodgkin lymphoma (NHL) that has gotten worse within 6 months of treatment with other anticancer drugs.It is being studied in the treatment of other types of cancer. Bendamustine hydrochloride may damage the DNA in cancer cells and cause them to die. It is a type of alkylating agent and a type of antimetabolite. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C001758 |
SnomedCT | 430082006 |
English | Bendamustine Hydrochloride, Bendamustin Hydrochloride, 2-Benzimidazolinebutryric acid, 1-methyl-5-bis(2-chloroethyl)amino-, hydrochloride, Bendamustine hydrochloride (substance), bendamustine hydrochloride, Cytostasan Hydrochloride, Bendamustine hydrochloride, bendamustine HCL, BENDAMUSTINE HYDROCHLORIDE |
Spanish | clorhidrato de bendamustina, clorhidrato de bendamustina (sustancia) |