II. Indications

III. Mechanism

  1. See Alkylating Agent
  2. Nitrogen Mustard derived antineoplastic Alkylating Agent
  3. Mechlorethamine derivative with alkylator and antimetabolite properties
    1. Alkylating group (cross-links DNA)
    2. Purine Analogue (DNA, RNA and Protein synthesis inhibitor)
    3. Vesicant

IV. Medications

  1. Treanda 25 mg and 100 mg vials containing powder for preparation of IV solution
  2. Bendeka 100 mg/4 ml IV solution

V. Dosing

  1. See other references for disease specific dosing protocols

VI. Pharmacokinetics

  1. Hepatic metabolism to both active and inactive metabolites

VII. Safety

  1. Avoid in Lactation
  2. Avoid in pregnancy (contraindicated in all trimesters)
    1. Teratogenic and adverse outcomes
    2. Use reliable Contraception
  3. Monitoring
    1. Complete Blood Count
    2. Renal Function tests

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