II. Indications

  1. Colorectal Liver Metastases (Palliative Care)

III. Mechanism

  1. Fluorinated Pyrimidine Antimetabolite Chemotherapy with antineoplastic activity
  2. Analog of FUDR-MP
    1. Inhibits thymidylate synthase, blocking DNA synthesis
  3. Also metabolized to Fluorouracil
    1. As a uracil analog, Fluorouracil inhibits RNA synthesis

IV. Medications

  1. Floxuridine IV Solution
    1. Available in 0.5 g vials of lyophilized powder for reconstitution

V. Dosing

  1. See other references for disease specific dosing protocols
  2. Colorectal Liver Metastases
    1. Administered by infusion pump via intrahepatic artery

VI. Adverse Effects

  1. Myelosuppression
  2. Nephrotoxicity
  3. Hepatotoxicity
  4. Alopecia

VII. Safety

  1. Avoid in Lactation
  2. Avoid in pregnancy (all trimesters)
    1. Use reliable Contraception
  3. Monitoring
    1. Complete Blood Count
    2. Liver Function Tests
    3. Renal Function tests

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Related Studies

Ontology: Floxuridine (C0016343)

Definition (NCI) A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04)
Definition (NCI_NCI-GLOSS) A drug used in the treatment of cancer. It is a type of antimetabolite.
Definition (MSH) An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Definition (CSP) antineoplastic antimetabolite; has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Definition (PDQ) A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthetase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39242&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39242&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C504" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114)
MSH D005467
SnomedCT 387432008, 75927008
English 5-Fluorodeoxyuridine, 5-FUdR, Floxuridine, Fluorodeoxyuridine, FUdR, 5 Fluorodeoxyuridine, floxuridine, Uridine, 2'-deoxy-5-fluoro-, 2-Deoxy-5-fluorouridine, 5-Fluoro-2'-deoxy-beta-uridine, 5-Fluorouracil Deoxyriboside, 5-Fluorouridine Deoxyribose, 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil, 2'-Deoxy-5-fluorouridine, FDUR, 5FUDR, 5-fluorouracil deoxyriboside, 5-fluorodeoxyuridine, Fluorouridine Deoxyribose, 2'-deoxy-5-fluorouridine, 5 fluorodeoxyuridine, floxuridine (medication), FLOXURIDINE, Floxuridine [Chemical/Ingredient], 5-furd, fdurd, fudr, 5-FUDR, 5-Fluorouracil deoxyriboside, Fluoruridine deoxyribose, FUDR, Floxuridine (product), Floxuridine (substance), FdUrD, floxuridin, fluorodeoxyuridine, fluoruridine deoxyribose, Floxuridin, Fluoruridine Deoxyribose
Swedish Floxuridin
Czech floxuridin, fluorodeoxyuridin
Finnish Fluorodeoksiuridiini
Russian FTORDEZOKSIURIDIN, FLOKSURIDIN, FUDR, ФЛОКСУРИДИН, ФТОРДЕЗОКСИУРИДИН, ФУДР
Japanese 5-フルオロ-2'-デオキシウリジン, 2'-デオキシ-5-フルオロウリジン, 5-フルオロデオキシウリジン, フルオロデオキシウリジン, フロキシウリジン, フロクスウリジン
Italian 5-FUdR, 5-Fluorodeossiuridina, Fluorodeossiuridina, FUdR, Flossuridina
Polish Floksurydyna, Fudr, Fluorodezoksyurydyna
Spanish floxuridina (producto), floxuridina (sustancia), floxuridina, fluorodesoxiuridina, Floxuridina, Fluorodeoxiuridina, FUdR
French Désoxyfluorouridine, Floxuridine, uridine fluoro-5' désoxy-2'
German FUdR, Floxuridin, Fluordesoxyuridin
Portuguese Floxuridina, FUdR, Fluordesoxiuridina