Definition (NCI)
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A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04)
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Definition (NCI_NCI-GLOSS)
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A drug used in the treatment of cancer. It is a type of antimetabolite.
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Definition (MSH)
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An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
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Definition (CSP)
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antineoplastic antimetabolite; has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
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Definition (PDQ)
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A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthetase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39242&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39242&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C504" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Nucleic Acid, Nucleoside, or Nucleotide
(T114)
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MSH |
D005467
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SnomedCT |
387432008, 75927008 |
English |
5-Fluorodeoxyuridine, 5-FUdR, Floxuridine, Fluorodeoxyuridine, FUdR, 5 Fluorodeoxyuridine, floxuridine, Uridine, 2'-deoxy-5-fluoro-, 2-Deoxy-5-fluorouridine, 5-Fluoro-2'-deoxy-beta-uridine, 5-Fluorouracil Deoxyriboside, 5-Fluorouridine Deoxyribose, 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil, 2'-Deoxy-5-fluorouridine, FDUR, 5FUDR, 5-fluorouracil deoxyriboside, 5-fluorodeoxyuridine, Fluorouridine Deoxyribose, 2'-deoxy-5-fluorouridine, 5 fluorodeoxyuridine, floxuridine (medication), FLOXURIDINE, Floxuridine [Chemical/Ingredient], 5-furd, fdurd, fudr, 5-FUDR, 5-Fluorouracil deoxyriboside, Fluoruridine deoxyribose, FUDR, Floxuridine (product), Floxuridine (substance), FdUrD, floxuridin, fluorodeoxyuridine, fluoruridine deoxyribose, Floxuridin, Fluoruridine Deoxyribose |
Swedish |
Floxuridin
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Czech |
floxuridin, fluorodeoxyuridin |
Finnish |
Fluorodeoksiuridiini
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Russian |
FTORDEZOKSIURIDIN, FLOKSURIDIN, FUDR, ФЛОКСУРИДИН, ФТОРДЕЗОКСИУРИДИН, ФУДР |
Japanese |
5-フルオロ-2'-デオキシウリジン, 2'-デオキシ-5-フルオロウリジン, 5-フルオロデオキシウリジン, フルオロデオキシウリジン, フロキシウリジン, フロクスウリジン |
Italian |
5-FUdR, 5-Fluorodeossiuridina, Fluorodeossiuridina, FUdR, Flossuridina |
Polish |
Floksurydyna, Fudr, Fluorodezoksyurydyna |
Spanish |
floxuridina (producto), floxuridina (sustancia), floxuridina, fluorodesoxiuridina, Floxuridina, Fluorodeoxiuridina, FUdR |
French |
Désoxyfluorouridine, Floxuridine, uridine fluoro-5' désoxy-2' |
German |
FUdR, Floxuridin, Fluordesoxyuridin |
Portuguese |
Floxuridina, FUdR, Fluordesoxiuridina |