II. Indications
- FDA Approved
- Off-Label
- Breast Cancer
- Cervical Cancer
- Hodgkin Lymphoma
- Mesothelioma (malignant, pleural)
- Ovarian Cancer
- Salivary Gland Cancer
- Small Cell Lung Cancer (refractory)
- Soft Tissue Sarcoma (advanced)
III. Mechanism
- See Mitotic Inhibitor Chemotherapy
- Vinorelbine is a semisynthetic Vinca Alkaloid, Antineoplastic Agent
- Vinorelbine is an antitubulin agent similar to the natural Vinca Alkaloids (e.g. Vincristine)
- Binds tubulin and inhibits microtubule formation
- Disrupts mitotic spindle formation
- Arrests Cell Cycle in M phase (Metaphase)
- Other possible activity
- Interferes with metabolism of Amino Acids cAMP, glutathione
- Interferes with calmodulin-dependent Calcium transport ATPase activity
- Interferes with biosynthesis of Nucleic Acids and lipids
IV. Medications
- Vinorelbine Injection Solution: 10 mg/ml and 50 mg/5 ml vials
V. Dosing
- See other references for disease specific dosing protocols
VI. Adverse Effects
- Alopecia
- Bronchospasm (and other pulmonary toxicity)
-
Peripheral Neuropathy
- Less neurotoxicity than other Vinca Alkaloids (lower affinity for nerve tubules)
- Severe skin and soft tissue necrosis on extravasation
- Vinblastine is a strong Vesicant (causes Blistering)
- Hepatotoxicity
- Increased Liver Function Tests
- Myelosuppression (Bone Marrow suppression)
- Granulocytopenia (including Neutropenia)
VII. Safety
- Avoid in Lactation
- Avoid in pregnancy (all trimesters)
- Use reliable Contraception
- Monitoring
VIII. Resources
- Vinorelbine Injection Solution (DailyMed)
IX. References
X. References
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
| Definition (NCI_NCI-GLOSS) | An anticancer drug that belongs to the family of plant drugs called vinca alkaloids. |
| Definition (NCI) | A semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. This agent may also interfere with amino acid, cyclic AMP. and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C030852 |
| SnomedCT | 108792008, 372541004 |
| English | 5'-nor-anhydrovinblastine, C'-Norvincaleukoblastine, 3',4'-didehydro-4'-deoxy-, nor-5'-Anhydrovinblastine, 5'-Nor-Anhydrovinblastine, 3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine, NVB, vinorelbine, vinorelbine (medication), vinorelbine [Chemical/Ingredient], VINORELBINE, Vinorelbine, Vinorelbine (product), Vinorelbine (substance), VNB, Dihydroxydeoxynorvinkaleukoblastine |
| Spanish | vinorelbina (sustancia), vinorelbina, vinorelbina (producto) |
