Definition (CHV)
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a kind of cancer treatment drug
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Definition (CHV)
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a kind of cancer treatment drug
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Definition (CHV)
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a kind of cancer treatment drug
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Definition (NCI)
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A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. (NCI04)
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Definition (NCI_NCI-GLOSS)
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An anticancer drug that belongs to the family of drugs called antimetabolites.
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Definition (CSP)
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thioguanine is USP.
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Definition (MSH)
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An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
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Definition (PDQ)
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A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43669&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43669&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C876" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D013866
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SnomedCT |
387407006, 72623000 |
LNC |
LP30750-1, LP31792-2, MTHU014979, MTHU027390 |
English |
6-Thioguanine, Thioguanine, 6 thioguanine, 6H-Purine-6-thione, 2-amino-1,7-dihydro-, Tioguanine, thioguanine, 6 Thioguanine, 2-Amino 6MP, 2-Amino-1,7-dihydro-6H-purine-6-thione, 2-Amino-6-purinethiol, 2-Aminopurin-6-thiol, 2-Aminopurine-6(1H)-thione, 2-Aminopurine-6-thiol, 6 Mercaptoguanine, 6-Mercapto-2-aminopurine, 6H-Purine-6-thione, 2-amino-1,7-dihydro- (9CI), 6-mercaptoguanine, 6-thioguanine, THIOGUANINE 06, 2-amino-6-mercaptopurine (thioguanine) (medication), thioguanine (medication), 2-amino-6-mercaptopurine (thioguanine), THIOGUANINE, 2-Amino-6-Purinethiol, 2 Amino 6 Purinethiol, Thioguanine [Chemical/Ingredient], tioguanine, Tioguanin, 6-Mercaptoguanine, 2-Mercapto-6-aminopurine, 6-Amino-2-mercaptopurine, 2-Amino-6-mercaptopurine, 6-TG, TG, Thioguanine (product), Thioguanine (substance) |
Swedish |
Tioguanin
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Czech |
thioguanin
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Finnish |
Tioguaniini
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Russian |
TIOGUANIN, 6-TIOGUANIN, 6-ТИОГУАНИН, ТИОГУАНИН |
Japanese |
チオグアニン, 6-チオグアニン |
German |
THIOGUANIN 06, 6-Thioguanin, Thioguanin |
Italian |
6-Tioguanina, Tioguanina |
Polish |
Tioguanina
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Spanish |
2-amino-6-mercaptopurina, 6-tioguanina, tioguanina (producto), tioguanina (sustancia), tioguanina, 6-Tioguanina, Tioguanina |
French |
Thioguanine, Tioguanine |
Portuguese |
6-Tioguanina, Tioguanina |