II. Indications

  1. Prostate Cancer (advanced, metastatic, castration resistant)
    1. In combination with a GnRH Agonist or surgical castration

III. Mechanism

  1. Steroid antiandrogen that inhibits the enzyme CYP17, in the Testosterone synthesis pathway
  2. Decreases Testosterone synthesis at the Testes and Adrenal Glands

IV. Dosing

  1. Abiraterone 1000 mg orally once daily
    1. Combined with Prednisone 5 mg orally once to twice daily
    2. Decrease dose to 250 mg orally daily in moderate hepatic Impairment (Child-Pugh Class B)

V. Adverse Effects

VI. Safety

  1. Avoid in Lactation
  2. Avoid in pregnancy
    1. Women should use reliable Contraception for >=3 weeks after their male partner's last dose

VII. Drug Interactions

  1. Strong CYP3A4 Inducers
    1. Avoid with Abiraterone
  2. CYP2D6 Substrates with a narrow Therapeutic Index
    1. Avoid with Abiraterone

IX. References

  1. (2022) Presc Lett, Medications to treat Prostate Cancer, Resource #380108

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Cost: Medications

abiraterone (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
ABIRATERONE ACETATE 250 MG TAB Generic $1.46 each