II. Indications

  1. Prostate Cancer (advanced, metastatic, castration resistant)
    1. In combination with a GnRH Agonist or surgical castration

III. Mechanism

  1. Steroid antiandrogen that inhibits the enzyme CYP17, in the Testosterone synthesis pathway
  2. Decreases Testosterone synthesis at the Testes and Adrenal Glands

IV. Dosing

  1. Abiraterone 1000 mg orally once daily
    1. Combined with Prednisone 5 mg orally once to twice daily
    2. Decrease dose to 250 mg orally daily in moderate hepatic Impairment (Child-Pugh Class B)

V. Adverse Effects

VI. Safety

  1. Avoid in Lactation
  2. Avoid in pregnancy
    1. Women should use reliable Contraception for >=3 weeks after their male partner's last dose

VII. Drug Interactions

  1. Strong CYP3A4 Inducers
    1. Avoid with Abiraterone
  2. CYP2D6 Substrates with a narrow Therapeutic Index
    1. Avoid with Abiraterone

IX. References

  1. (2022) Presc Lett, Medications to treat Prostate Cancer, Resource #380108

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Related Studies

Cost: Medications

abiraterone (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
ABIRATERONE ACETATE 250 MG TAB Generic $1.46 each

Ontology: abiraterone (C0754011)

Definition (NCI) A steroidal compound with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex; CYP17A1), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels.
Concepts Steroid (T110) , Pharmacologic Substance (T121)
MSH C089740
SnomedCT 699678007
English 17-(3-pyridyl)androsta-5,16-dien-3beta-ol, Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, (3beta)-, abiraterone, 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol, ABIRATERONE, Abiraterone (substance), Abiraterone
Spanish abiraterona, abiraterona (sustancia)

Ontology: Androgen Synthesis Inhibitors (C3853002)

Concepts Pharmacologic Substance (T121)
MSH D065088
English Synthesis Inhibitors, Androgen, Inhibitors, Androgen Synthesis, Androgen Synthesis Inhibitors