II. Differential Diagnosis
III. Mechanisms
- Drug-absorption or Hapten-induced
- Medication coats Red Blood Cell surface
- Induces IgG Antibody production
- Immune-complex
- Drug stimulates IgM production and binding
- Drug-IgM complex binds RBC and complement induced
- Autoantibody
- Drug stimulates IgG production against RBC membrane
IV. Causes: By Mechanism
-
Immune Hemolytic Anemia
- Beta-Lactamase Inhibitors (e.g. Sulbactam, Clavulanic Acid, Tazobactam)
- Cefotetan (common)
- Ceftriaxone (common)
- Fludarabine
- Intravenous Immunoglobulin (IV Ig)
- Methyldopa (common in past)
- NSAIDs (common)
- Penicillin (common in past)
- Piperacillin with Tazobactam or Zosyn (common)
- Thrombotic Microangiopathic Anemia (only 5% of MAHA Cases)
- Adalimumab (Humira)
- Bupropion (Wellbutrin)
- Chemotherapy
- Clopidogrel (Plavix)
- Cocaine
- Covid Vaccine (AstraZeneca and Johnson and Johnson Vaccine induced immune TTP, 5 to 30 days after dose)
- Cyclosporine (common cause)
- Gemcitabine (Gemzar)
- Ibuprofen
- Interferon
- Mefloquine
- Methylenedioxymethamphetamine (MDMA, Ecstacy)
- Metronidazole (Flagyl)
- Nitrofurantoin (Macrobid)
- Oxaliplatin (Eloxatin)
- Quetiapine (Seroquel)
- Quinine (common cause)
- Simvastatin (Zocor)
- Tacrolimus (Prograf, common cause)
- Trimethoprim Sulfamethoxazole (Bactrim, Septra)
- Oxidation Hemolysis
V. Causes: Extravascular (IgG) vs Intravascular Hemolysis (C3)
VI. References
- Ford (2001) Clinical Toxicology, p. 201-3
- Dhaliwal (2004) Am Fam Physician 69:2599-606 [PubMed]
- Lubran (1989) Ann Clin Lab Sci 19:114-21 [PubMed]
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Related Studies
Concepts | Disease or Syndrome (T047) |
SnomedCT | 81711008 |
English | Drug-induced hemolytic anemia, Drug-induced haemolyt anaemia, Drug-induced haemolyt anemia, drug-induced hemolytic anemia, anemia drugs hemolytic induced, drug induced hemolytic anemia, Haemolytic anaemia drug-induced, Hemolytic anemia drug-induced, Drug-induced haemolytic anaemia, Haemolytic anaemia due to drugs, Hemolytic anemia due to drugs (disorder), Hemolytic anemia due to drugs, Drug-induced hemolytic anemia, NOS, Hemolytic anemia due to drugs, NOS |
Dutch | hemolytische anemie geneesmiddelgeïnduceerd |
French | Anémie hémolytique médicamenteuse, Anémie hémolytique induite par un médicament |
German | haemolytische Anaemie arzneimittelbedingt, haemolytische Anaemie, arzneimittelbedingt |
Italian | Anemia emolitica da farmaci |
Portuguese | Anemia hemolítica farmacoinduzida |
Spanish | Anemia hemolítica inducida por fármacos, Anemia hemolítica autoinmune inducida por medicamentos, anemia hemolítica farmacógena, anemia hemolítica medicamentosa (trastorno), anemia hemolítica medicamentosa |
Japanese | ヤクザイユウハツセイヨウケツセイヒンケツ, 薬剤誘発性溶血性貧血 |
Czech | Léky indukovaná hemolytická anémie, Poléková hemolytická anémie |
Hungarian | gyógyszer-által kiváltott Haemolytikus anaemia, Haemolyticus gyógyszer-által kiváltott anaemia |
Ontology: Drug-induced autoimmune hemolytic anemia (C0391817)
Concepts | Pathologic Function (T046) |
ICD10 | D59.0 |
SnomedCT | 191214001, 309742004 |
English | Drug-induced autoim haem anaem, drug-induced autoimmune hemolytic anemia, drug-induced autoimmune hemolytic anemia (diagnosis), anemia hemolytic drug-induced autoimmune, Drug-induced autoimmune haemolytic anaemia (disorder), Drug-induced autoimmune haemolytic anaemia, Drug-induced autoimmune hemolytic anemia, Drug-induced autoimmune hemolytic anemia (disorder), anemia; hemolytic drug-induced, autoimmune |
German | Arzneimittelinduzierte autoimmunhaemolytische Anaemie |
Korean | 약물유발성 자가면역성 용혈성 빈혈 |
Dutch | anemie; hemolytisch door geneesmiddelen, auto-immuun, Door geneesmiddelen geïnduceerde auto-immune hemolytische anemie |
Spanish | anemia hemolítica autoinmunitaria medicamentosa (trastorno), anemia hemolítica autoinmunitaria medicamentosa |
Ontology: Drug-induced immune hemolytic anemia (C1096070)
Concepts | Disease or Syndrome (T047) |
SnomedCT | 127059001 |
English | Drug-induced immune hemolytic anemia, drug related immune hemolytic anemia, hemolytic anemia due to drug related immune complexes (diagnosis), hemolytic anemia due to drug related immune complexes, Immune hemolytic anemia drug-induced, Immune haemolytic anaemia drug-induced, Drug-induced immune haemolytic anaemia, Drug-induced immune hemolytic anemia (disorder) |
Dutch | immune hemolytische anemie geneesmiddelgeïnduceerd |
French | Anémie hémolytique immune induite par médicament, Anémie hémolytique médicamenteuse auto-immune |
German | haemolytische Anaemie, arzneimittelbedingt, immunhaemolytische Anaemie arzneimittelbedingt |
Italian | Anemia emolitica autoimmune da farmaci |
Portuguese | Anemia hemolítica imune induzida por fármacos, Anemia hemolítica imune farmacoinduzida |
Spanish | Anemia hemolítica autoinmune inducida por fármacos, Anemia hemolítica autoinmune medicamentosa, anemia hemolítica inmunitaria medicamentosa (trastorno), anemia hemolítica inmunitaria medicamentosa |
Japanese | 薬剤誘発性免疫性溶血性貧血, ヤクザイユウハツセイメンエキセイヨウケツセイヒンケツ |
Czech | Imunitně podmíněná léky indukovaná hemolytická anémie, Imunitně podmíněná poléková hemolytická anémie |
Hungarian | Immunhaemolyticus gyógyszer-által kiváltott anaemia, Immun haemolytikus gyógyszer-által kiváltott anaemia |