Definition (CHV)
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A drug used to help reduce the risk of rejection of organ and bone marrow transplants by the body
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Definition (CHV)
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A drug used to help reduce the risk of rejection of organ and bone marrow transplants by the body
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Definition (CHV)
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A drug used to help reduce the risk of rejection of organ and bone marrow transplants by the body
|
Definition (CHV)
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A drug used to help reduce the risk of rejection of organ and bone marrow transplants by the body
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Definition (CHV)
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A drug used to help reduce the risk of rejection of organ and bone marrow transplants by the body
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Definition (CHV)
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A drug used to help reduce the risk of rejection of organ and bone marrow transplants by the body
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Definition (NCI)
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A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04)
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Definition (NCI_NCI-GLOSS)
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A drug used to help reduce the risk of rejection of organ and bone marrow transplants by the body. It is also used in clinical trials to make cancer cells more sensitive to anticancer drugs.
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Definition (MSH)
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A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
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Definition (CSP)
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11-residue cyclic peptide produced by certain fungi which has antifungal and T cell specific immunosuppressive properties.
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Definition (PDQ)
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A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39201&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39201&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C406" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Amino Acid, Peptide, or Protein
(T116)
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MSH |
D016572
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SnomedCT |
387467008, 255649004, 80906007 |
LNC |
LP16098-3, MTHU005140, LA16776-9 |
English |
Cyclosporin, Cyclosporin A, Cyclosporine, Cyclosporine A, Ciclosporin, cyclosporine, cyclosporine (medication), cyclosporin-A (medication), cyclosporin-A, Cyclosporin - chemical, CYCLOSPORINE, Cyclosporine [Chemical/Ingredient], cyclosporin a, cyclosporine a, ciclosporins, cycloSPORINE, ciclosporin, Cyclosporin - chemical (substance), Ciclosporin - chemical, CYA - Cyclosporin, Cyclosporin product, CSA - Cyclosporin A, CYA - Cyclosporin A, Cyclosporine (product), Cyclosporine (substance), cyclosporin, cyclosporin A, CYSP, Ciclosporin product, CsA, CycloSPORINE A, CycloSPORINE |
Swedish |
Ciklosporin
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Czech |
cyklosporin, Consupren, cyklosporin A |
Finnish |
Siklosporiini
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French |
Ciclosporine, Cyclosporine, Ciclosporine A, Cyclosporine A |
Russian |
TSIKLOSPORIN A, TSIKLOSPORIN, ЦИКЛОСПОРИН A, ЦИКЛОСПОРИН |
Japanese |
サイクロスポリン, シクロスポリンA, サイクロスポリンA, シクロスポリン, サンディミュン, ネオーラル, ネオメルク, アマドラ, シクポラール, パピロック |
Croatian |
CIKLOSPORIN
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Polish |
Cyklosporyna A
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Spanish |
ciclosporina - sustancia química, ciclosporina - sustancia química (sustancia), ciclosporina (producto), ciclosporina (sustancia), ciclosporina A, ciclosporina, Ciclosporina, Ciclosporina A |
German |
Cyclosporin A, Cyclosporin |
Italian |
Ciclosporina
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Portuguese |
Ciclosporina A, Ciclosporina |